Microbiota, Tryptophan and Aryl Hydrocarbon Receptors as the Target Triad in Parkinson's Disease-A Narrative Review. [PDF]
Int J Mol SciIwaniak P, Owe-Larsson M, Urbańska EM.
europepmc +1 more source
Aging Cell, Volume 25, Issue 5, May 2026.The steroid hormone ADIOL emerges as a key mediator of fasting–and caloric restriction–induced healthspan benefits in C. elegans. These regimens activate ADIOL production, which acts through the estrogen receptor β homolog NHR‐91 to reduce neural kynurenic acid levels and enhance healthspan independently of lifespan. ADIOL supplementation, even late in
Ana Guijarro‐Hernández +6 more
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Embryonic and Postnatal Expression of Aryl Hydrocarbon Receptor mRNA in Mouse Brain [PDF]
, 2017 Eiki Kimura, Chiharu Tohyama
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T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets
Aging Cell, Volume 25, Issue 5, May 2026.Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu +3 more
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British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi +10 more
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Overexpression of the Aryl Hydrocarbon Receptor (Ahr) Mediates an Oxidative Stress Response following Injection of Fine Particulate Matter in the Temporal Cortex [PDF]
, 2020 So Young Kim +6 more
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Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension
British Journal of Pharmacology, Volume 183, Issue 9, Page 1824-1844, May 2026.Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam +12 more
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The Aryl Hydrocarbon Receptor (AhR) Level Based on Age and Clinical Type of Melasma
Rezkyana Danil +2 more
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The aryl hydrocarbon receptor pathway is a marker of lung cell activation but does not play a central pathologic role in engineered stone‐associated silicosis [PDF]
Yong Song +5 more
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