Results 21 to 30 of about 44,282 (308)
Atypical functions of xenobiotic receptors in lipid and glucose metabolism
Medical Review, 2022 Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors, the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and disposition of xenobiotics.
Wang Jingyuan, Lu Peipei, Xie Wen
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The aryl hydrocarbon receptor system [PDF]
dmdi, 2012 Abstract The aryl hydrocarbon receptor (AhR) recognizes a large number of xenobiotics, such as polyaromatic hydrocarbons (PAHs) and dioxins, and it activates several metabolic and detoxification pathways. Recent evidence suggests that this receptor also has important endogenous functions subsequent to activation by natural dietary ...
Barouki, Robert +3 more
openaire +2 more sources
Nuclear receptors: a bridge linking the gut microbiome and the host
Molecular Medicine, 2021 Background The gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut microbiome plays key roles in various physiological and pathological processes through regulating varieties
Zixuan Wang +2 more
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Lipoxin-mediated signaling: ALX/FPR2 interaction and beyond
Pharmacological Research, 2023 In the aftermath of tissue injury or infection, an efficient resolution mechanism is crucial to allow tissue healing and preserve appropriate organ functioning. Pro-resolving bioactive lipids prevent uncontrolled inflammation and its consequences.
Sergio Sánchez-García +5 more
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Frontiers in Immunology, 2022 Rheumatoid arthritis (RA), the most common autoimmune disease, is characterized by symmetrical synovial inflammation of multiple joints with the infiltration of pro-inflammatory immune cells and increased cytokines (CKs) levels.
Xiaoyu Xi +15 more
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Basic & Clinical Pharmacology & Toxicology, 2018 Pregnane X receptor (PXR), constitutive androstane receptor (CAR), aryl hydrocarbon receptor (AHR) and peroxisome proliferator-activated receptor α (PPARα) are ligand-activated transcription factors that regulate expression of many xenobiotic ...
J. Hakkola +5 more
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Frontiers in Microbiology, 2021 National screening programs use dried blood specimens to detect metabolic disorders or aberrant protein functions that are not clinically evident in the neonatal period.
Anne-Christine Aust +10 more
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Frontiers in Immunology, 2020 ObjectivesSemaphorin 4D (Sema4D) is constitutively expressed on T cells and osteoclasts, and regulates T cell proliferation and bone remodeling. In addition, several studies have shown that Sema4D is involved in the pathogenesis of autoimmunity.
Jianmin Xie, Zitao Wang, Wen Wang
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AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor
Nature Communications, 2017 In this work the authors show that AIP (aryl hydrocarbon receptor-interacting protein), a gene frequently mutated in association with pituitary tumors, regulates neurotransmitter release by inhibiting calcium release from ryanodine receptors.
Bojun Chen +5 more
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Role of gut microbiota-derived signals in the regulation of gastrointestinal motility
Frontiers in Medicine, 2022 The gastrointestinal (GI) tract harbors trillions of commensal microbes, called the gut microbiota, which plays a significant role in the regulation of GI physiology, particularly GI motility.
Zhipeng Zheng +3 more
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