Evolutionary formation of melatonin and vitamin D in early life forms: insects take centre stage
Biological Reviews, Volume 99, Issue 5, Page 1772-1790, October 2024.ABSTRACT Melatonin, a product of tryptophan metabolism via serotonin, is a molecule with an indole backbone that is widely produced by bacteria, unicellular eukaryotic organisms, plants, fungi and all animal taxa. Aside from its role in the regulation of circadian rhythms, it has diverse biological actions including regulation of cytoprotective ...
Tae‐Kang Kim +7 more
wiley +1 more source
Interaction between dietary and lifestyle risk factors and N-Acetyltransferase polymorphisms in B-Cell lymphoma etiology [PDF]
, 2015 Background: Gene-environment interactions are suggested to play a role in lymphomagenesis. Methods: We tested the interaction between the NAT1/NAT2 phenotype, as inferred by the respective genotypes, and exposure to dietary and lifestyle risk factors ...
Angelucci, E +9 more
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American Journal of Human Biology, Volume 36, Issue 4, April 2024.Abstract Objectives Previous research revealed that in some African populations, food‐production strategies are associated with facial shape. Nomadic pastoralists living in the African Sahel/Savannah belt have a different facial morphology than their sedentary neighbors. We investigated whether the lifestyle associated with a subsistence pattern has an
Karel Kleisner +2 more
wiley +1 more source
Leukocytoclastic vasculitis caused by sulfamethoxazole‐trimethoprim
Clinical Case Reports, Volume 12, Issue 2, February 2024.Violaceous round papules and a surrounding rim of macular purpura coalescing into plaques on both feet 8 days after starting sulfamethoxazole‐trimethoprim. Key Clinical Message Leukocytoclastic vasculitis is a rare, small‐vessel vasculitis that can be caused by sulfamethoxazole‐trimethoprim.
Parjanya Bhatt +5 more
wiley +1 more source
The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) [PDF]
, 2017 The metabolic activation of the heterocyclic food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) by two human cytochrome P450 monooxygenases (P4501A1 and P4501A2) and two human N-acetyltransferases (NAT1 and NAT2) was investigated.
Blum, Martin +5 more
core
Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes [PDF]
, 2018 Rifampin is a pleiotropic inducer of multiple drug metabolizing enzymes and transporters. This work utilized a global approach to evaluate rifampin effects on conjugating enzyme gene expression with relevance to human xeno- and endo-biotic metabolism ...
Desta, Zeruesenay +7 more
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Molecular Pharmacology, 2019 Arylamine N-acetyltransferase 1 (NAT1) is a drug-metabolizing enzyme that influences cancer cell proliferation and survival. However, the mechanism for these effects is unknown. Because of previous observations that NAT1 inhibition decreases invasiveness,
Pengcheng Li, N. Butcher, R. Minchin
semanticscholar +1 more source
Antimicrobial properties of garlic oil against human enteric bacteria: evaluation of methodologies and comparisons with garlic oil sulfides and garlic powder. [PDF]
, 2001 The antimicrobial effects of aqueous garlic extracts are well established but those of garlic oil (GO) are little known. Methodologies for estimating the antimicrobial activity of GO were assessed and GO, GO sulfide constituents, and garlic powder (GP ...
Hill, David J. +4 more
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Effects of single nucleotide polymorphisms on human N-acetyltransferase 2 structure and dynamics by molecular dynamics simulation. [PDF]
PLoS ONE, 2011 BACKGROUND: Arylamine N-acetyltransferase 2 (NAT2) is an important catalytic enzyme that metabolizes the carcinogenic arylamines, hydrazine drugs and chemicals. This enzyme is highly polymorphic in different human populations.
M Rajasekaran +2 more
doaj +1 more source
Bisphenol A‐associated alterations in the expression and epigenetic regulation of genes encoding xenobiotic metabolizing enzymes in human fetal liver [PDF]
, 2013 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106679/1/em21823 ...
Dolinoy, Dana C. +3 more
core +1 more source