Results 101 to 110 of about 17,285 (228)
Kinetic characterization of arylamine N‐acetyltransferase 2
The FASEB Journal, 2008 N‐acetyltransferase 2 (NAT 2) is an enzyme that catalyzes the acetylation of harmful arylamines and has been implicated in various types of cancer. NAT 2 is primarily expressed in the hepatic system and intestinal epithelium and is encoded at two polymorphic loci that give the phenotypic characteristics of slow and fast acetylation. The purpose of this
Inesha Baker, Chasta L Parker
openaire +2 more sources
N-Acetylation phenotype and genotype and risk of bladder cancer in benzidine-exposed workers [PDF]
, 2017 Several studies in subjects occupationally exposed to arylamine carcinogens have shown increased risks for bladder cancer associated with the slow acetylator phenotype.
Bi, Wenfang +9 more
core
Acta Pharmaceutica Sinica B, 2018 Arylamine N-acetyltransferase (NAT; E.C. 2.3.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation.
Eneida Turiján-Espinoza +6 more
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Polymorphism Analysis of Genes Involved in Xenobiotic Metabolism and Circadian Rhythm in Human Breast Cancer [PDF]
, 2013 Individual response to xenobiotic exposures depends on the dynamics of xenobiotic metabolism and the circadian clock system, among other factors.
Cerliani, María Belén +1 more
core +1 more source
Molecular Pharmacology, 2019 Arylamine N-acetyltransferase 1 (NAT1) is a drug-metabolizing enzyme that influences cancer cell proliferation and survival. However, the mechanism for these effects is unknown. Because of previous observations that NAT1 inhibition decreases invasiveness,
Pengcheng Li, N. Butcher, R. Minchin
semanticscholar +1 more source
Data in Brief, 2022 Arylamine N-acetyltransferase 1 (NAT1) is frequently upregulated in breast cancer. An unbiased analysis of proteomes of parental MDA-MB-231 breast cancer cells and two separate NAT1 knockout (KO) cell lines were performed. Among 4,890 proteins identified,
Kyung U. Hong +8 more
doaj
Frontiers in Physiology, 2015 The evolution of N-acetyltransfeases (NATs) seems complex. Vertebrate arylalkylamine N-acetyltransferase (aaNAT) has been extensively studied since it Leads to the synthesis of melatonin, a multifunctional neurohormone prevalent in photoreceptor cells ...
Susumu eHiragaki +3 more
doaj +1 more source
What Differs on the Enzymatic Acetylation Mechanisms for Arylamines and Arylhydrazines Substrates? A Theoretical Study [PDF]
, 2009 The acetylation mechanisms of several selected typical substrates from experiments, including arylamines and arylhydrazines, are investigated with the density functional theory in this paper.
Cai, Zheng-Ting +6 more
core +3 more sources
Arylamine N-acetyltransferase 2 genotypes in a Mexican population
Genetics and Molecular Research, 2012 The acetylating activity of N-acetyltransferase 2 (NAT2) has critical implications for therapeutics and disease susceptibility. To date, several polymorphisms that alter the enzymatic activity and/or protein stability of NAT2 have been identified. We examined the distribution and frequency of NAT2 genotypes in the Mexican population.
Alma Chavez-Blanco +4 more
openaire +3 more sources
Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis
Sultan Qaboos University Medical Journal, 2003 Objective: to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. Method: Identify the most common known polymorphisms of NAT*2 gene namely, G191A, C282T, C341T, C481T, G590A, A803G and G857A ...
Musbah O. M. Tanira +5 more
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