Kinetic characterisation of arylamine N-acetyltransferase from Pseudomonas aeruginosa [PDF]
BMC Biochemistry, 2007 BACKGROUND: Arylamine N-acetyltransferases (NATs) are important drug- and carcinogen-metabolising enzymes that catalyse the transfer of an acetyl group from a donor, such as acetyl coenzyme A, to an aromatic or heterocyclic amine, hydrazine, hydrazide or
Sim, Edith, Westwood, Isaac M
core +7 more sources
Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1. [PDF]
Arch Toxicol, 2022 Leggett CS +5 more
europepmc +2 more sources
Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population
Annals of Human Biology, 2017 Background: The arylamine N-acetyltransferase 2 (NAT2) is a key enzyme in the biotransformation of xenobiotics. NAT2 gene polymorphisms have been associated with the risk of isoniazid hepatotoxicity and these polymorphisms change among different ...
Hiba Chelouti, Malika Khelil
doaj +4 more sources
Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review. [PDF]
Expert Opin Drug Metab Toxicol, 2021 Introduction The N-acetylation polymorphism has been the subject of comprehensive reviews describing the role of arylamine N-acetyltransferase 2 (NAT2) in the metabolism of numerous aromatic amine and hydrazine drugs. Areas covered We describe and review
Hein DW, Millner LM.
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Deletion of arylamine N-acetyltransferase 1 in MDA-MB-231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis. [PDF]
Mol Carcinog, 2022 Doll MA +9 more
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Effects of single nucleotide polymorphisms on human N-acetyltransferase 2 structure and dynamics by molecular dynamics simulation. [PDF]
PLoS ONE, 2011 BACKGROUND: Arylamine N-acetyltransferase 2 (NAT2) is an important catalytic enzyme that metabolizes the carcinogenic arylamines, hydrazine drugs and chemicals. This enzyme is highly polymorphic in different human populations.
M Rajasekaran +2 more
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Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2. [PDF]
Angew Chem Int Ed Engl, 2020 N‐Acetyltransferases play critical roles in the deactivation and clearance of xenobiotics, including clinical drugs. NAT2 has been classified as an arylamine N‐acetyltransferase that mainly converts aromatic amines, hydroxylamines, and hydrazines. Herein,
Conway LP +5 more
europepmc +2 more sources
Proteomic analysis of arylamine N-acetyltransferase 1 knockout breast cancer cells: Implications in immune evasion and mitochondrial biogenesis. [PDF]
Toxicol Rep, 2022 Hong KU +8 more
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CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism. [PDF]
Sci Rep, 2020 Human arylamine N-acetyltransferase 1 (NAT1), present in all tissues, is classically described as a phase-II xenobiotic metabolizing enzyme but can also catalyze the hydrolysis of acetyl-Coenzyme A (acetyl-CoA) in the absence of an arylamine substrate ...
Carlisle SM +4 more
europepmc +2 more sources
Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes. [PDF]
Sci Rep, 2020 Human N-acetyltransferases (NAT; EC 2.3.1.5) catalyze the N-acetylation of arylamine and hydrazine drugs and the O-acetylation of N-hydroxylated metabolites of aromatic and heterocyclic amines.
Salazar-González RA, Doll MA, Hein DW.
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