3-(5-Nitrofuran-2-yl)prop-2-en-1-one Derivatives, with Potent Antituberculosis Activity, Inhibit A Novel Therapeutic Target, Arylamine N-acetyltransferase, in Mycobacteria [PDF]
Antibiotics, 2020 In this study, the inhibitory potential of 3-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives was evaluated against a panel of bacteria, as well as mammalian cell lines to determine their therapeutic index.
Neha Agre +6 more
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NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
JD Ruiz +3 more
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Expression of arylamine N-acetyltransferase 2 activity in immortalized human bronchial epithelial cells. [PDF]
Toxicol Appl Pharmacol, 2022 Wise JTF +4 more
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Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages. [PDF]
PLoS ONE, 2012 Latent M. tuberculosis infection presents one of the major obstacles in the global eradication of tuberculosis (TB). Cholesterol plays a critical role in the persistence of M. tuberculosis within the macrophage during latent infection.
Areej Abuhammad +13 more
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BMC Medical Genetics, 2004 Background Alzheimer's disease is multifactorial, having environmental, toxicological and genetic risk factors. Impaired folate and homocysteine metabolism has been hypothesised to increase risk. In addition to its xenobiotic-metabolising capacity, human
Budge Marc +4 more
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Effects of human arylamine N-acetyltransferase I knockdown in triple-negative breast cancer cell lines. [PDF]
Cancer Med, 2015 Expression of human arylamine N‐acetyltransferase I (NAT1) has been associated with various cancer subtypes and inhibition of this enzyme with small molecule inhibitors or siRNA affects cell growth and survival.
Tiang JM, Butcher NJ, Minchin RF.
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Determination of Arylamine N-Acetyltransferase 2 Acetylation Genotype by PCR and Phenotyping Using Dapsone Through High-Pressure Liquid Chromatography Assay: A Gender Wise Study [PDF]
Dose-Response, 2019 The main aim of the study was to establish the acetylation status of local population of Pakistan by N-acetyltransferase 2 (NAT2) enzyme and to find out the concordance between phenotypic and genotypic methods for the determination of NAT2 acetylation ...
Naheed Akhter +5 more
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Sheep Tissue Acetyl Coenzyme A-Dependent Arylamine N-Acetyltransferases
Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1997 Acetyl coenzyme A-dependent arylamine N-acetyltransferases (NATs), EC 2.3.1.5. were measured in sheep tissues (N = 14) using p-aminobenzoic acid (PABA) as a substrate. Specific activities of liver, kidney, and lung NATs were 5.3 x 10(-3) +/- 1.4 (mean +/- SE) nmoles.min-1.mg protein-1, 3.4 x 10(-3) +/- 1.1 nmoles.min-1.mg protein-1, 2.5 x 10(-3) +/- 1 ...
Tülïn Güray, Tolga Güvenç
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Mycobacterium tuberculosis Arylamine N-Acetyltransferase Acetylates and Thus Inactivates para-Aminosalicylic Acid. [PDF]
Antimicrob Agents Chemother, 2016 Wang X, Yang S, Gu J, Deng J.
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Correction to Subcellular Protein Labeling by a Spatially Restricted Arylamine N-Acetyltransferase. [PDF]
ACS Chem Biol, 2019 Kleinpenning F +5 more
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