Results 41 to 50 of about 17,285 (228)

Arylamine N-acetyltransferase-1 reveals a subpopulation of ALS patients with altered metabolic capacity [PDF]

bioRxiv, 2023
Chandra Choudhury, Sally Allen, Melinder K. Gill, Fleur C. Garton, Restuadi Restuardi, Neville J. Butcher, Shyuan T. Ngo, Frederik J. Steyn, Rodney F. Minchin   +8 more
openalex   +2 more sources

Arylamine N-Acetyltransferases in Mycobacteria [PDF]

Current Drug Metabolism, 2008
Polymorphic Human arylamine N-acetyltransferase (NAT2) inactivates the anti-tubercular drug isoniazid by acetyltransfer from acetylCoA. There are active NAT proteins encoded by homologous genes in mycobacteria including M. tuberculosis, M. bovis BCG, M. smegmatis and M. marinum. Crystallographic structures of NATs from M. smegmatis and M.
Sim E, Sandy J, Evangelopoulos D, Fullam E, Bhakta S, Westwood I, Krylova A, Lack N, Noble MEM   +8 more
openaire   +4 more sources

Reaction Engineering and Comparison of Electroenzymatic and Enzymatic ATP Regeneration Systems

ChemElectroChem, Volume 10, Issue 22, November 14, 2023., 2023
An electrochemically coupled ATP regeneration by pyruvate oxidase and acetate kinase for the phosphorylation of mevalonate was established and expanded by a polyphosphate kinase. The reaction was characterized and compared with other ATP regenerating systems in terms of the phosphate donor properties and biocatalytic metrics.
Regine Siedentop, Tobias Prenzel, Siegfried R. Waldvogel, Katrin Rosenthal, Stephan Lütz   +4 more
wiley   +1 more source

Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review. [PDF]

Pharmacogenet Genomics, 2018
The arylamine N-acetyltransferase (NAT) nomenclature committee assigns functional phenotypes for human arylamine N-acetyltransferase 1 (NAT1) alleles in those instances in which the committee determined a consensus has been achieved in the scientific ...
Hein DW, Fakis G, Boukouvala S.
europepmc   +2 more sources

Genetic and small molecule inhibition of arylamine N-acetyltransferase 1 reduces anchorage-independent growth in human breast cancer cell line MDA-MB-231. [PDF]

Mol Carcinog, 2018
Stepp MW, Doll MA, Carlisle SM, States JC, Hein DW.   +4 more
europepmc   +2 more sources

Pharmacogenetics as part of recommended precision medicine for tuberculosis treatment in African populations: Could it be a reality?

Clinical and Translational Science, Volume 16, Issue 7, Page 1101-1112, July 2023., 2023
Abstract Globally, tuberculosis (TB) is the second most lethal infectious disease. However, in sub‐Saharan Africa, TB has the largest disease burden, with drug‐resistant TB increasingly becoming a concern. The social and economic impact of TB should not be overlooked, especially in areas where healthcare systems are overburdened, and resources need to ...
Carola Oelofse, Carene Anne Alene Ndong Sima, Marlo Möller, Caitlin Uren   +3 more
wiley   +1 more source

Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad. [PDF]

J Biol Chem, 2013
Kubiak X, Li de la Sierra-Gallay I, Chaffotte AF, Pluvinage B, Weber P, Haouz A, Dupret JM, Rodrigues-Lima F.   +7 more
europepmc   +3 more sources

Bioactivity and health effects of garlic essential oil: A review

Food Science &Nutrition, Volume 11, Issue 6, Page 2450-2470, June 2023., 2023
This paper reviews the research progress on the composition and bioactivities of garlic essential oil mixtures and the bioactivity of some typical monomeric sulfides in garlic essential oil. The active mechanisms of representative sulfides in garlic essential oil were analyzed, and the applications of garlic essential oil in functional food, food ...
Lei Huang, Zhenxin Liu, Jing Wang, Jiaolong Fu, Yonglu Jia, Lilian Ji, Taoyun Wang   +6 more
wiley   +1 more source

Effect of a hyaluronic acid‐based mesotherapeutic injectable on the gene expression of CLOCK and Klotho proteins, and environmentally induced oxidative stress in human skin cells

Journal of Cosmetic Dermatology, Volume 22, Issue 1, Page 156-172, January 2023., 2023
Abstract Objective Normal circadian rhythms are essential to the repair mechanisms of oxidative stress implicated in skin aging. Given reports that hyaluronic acid (HA) homeostasis exhibits a different profile in chronological skin aging, as compared to environmental or extrinsic aging, an improved understanding of the way HA interacts with its ...
Aleksei Prokopov, Anna Drobintseva, Igor Kvetnoy, Zarema Gazitaeva, Anna Sidorina   +4 more
wiley   +1 more source

Air pollution induces Staphylococcus aureus USA300 respiratory tract colonization mediated by specific bacterial genetic responses involving the global virulence gene regulators Agr and Sae

Environmental Microbiology, Volume 24, Issue 9, Page 4449-4465, September 2022., 2022
Summary Exposure to particulate matter (PM), a major component of air pollution, is associated with exacerbation of chronic respiratory disease, and infectious diseases such as community‐acquired pneumonia. Although PM can cause adverse health effects through direct damage to host cells, our previous study showed that PM can also impact bacterial ...
Jo Purves, Shane J. K. Hussey, Louise Corscadden, Lillie Purser, Andie Hall, Raju Misra, Liza Selley, Paul S. Monks, Julian M. Ketley, Peter W. Andrew, Julie A. Morrissey   +10 more
wiley   +1 more source