New Transient Directing Group: Diethoxyethyl-L-Proline Facilitate Mono ortho-Arylation at Ar-yl-Amines/-Amino acids via Pd-Catalysed C(sp2)-H Activation [PDF]
, 2022 The mono-ortho-arylated arylamines are constituents of various natural products but their syntheses are challenging. This report describes the new synthetic methodology for mono-ortho-arylation of aryla-mines and α-aromatic amino acids (Phenyl glycine ...
Nagendra, Sharma, Subhashree , Panda
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Direct α-C(sp<sup>3</sup>)─H Alkylation and Arylation of Ethers Enabled by Carbon Nitride/Nickel Metallaphotoredox Catalysis. [PDF]
ChemSusChemA recyclable carbon nitride/nickel metallaphotoredox platform enables direct α‐C(sp3)─H arylation and alkylation of ethers, amides, and benzylic substrates under visible light. Broad substrate scope, late‐stage functionalization, five‐cycle photocatalyst reuse, and continuous‐flow translation are demonstrated, while mechanistic studies support ...
de Vries Ibáñez MM +8 more
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, 2017 Arynes enable highly selective S-arylation and N-arylation.
Lin-Qing Bao +6 more
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Aryl Diazonium Salts: Powerful Arylating Agents for Catellani-Type ortho-Arylation
The Catellani reaction provides an efficient synthetic approach to polyfunctionalized arenes. However, the selective ortho-arylating reagents employed in these reactions have been strictly limited to activated bromoarenes.
Yu-Xia Zhang (75820) +2 more
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Advances in α-Arylation of Carbonyl Compounds: Diaryliodonium Salts as Arylating Agents
MoleculesDiaryliodonium salts are an important part of hypervalent iodine chemistry, owing to their highly electrophilic character, non-toxicity, and air and moisture stability, have been identified as an important arylating agent.
Xiao-Wei Chen +5 more
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“On Water” Palladium Catalyzed Direct Arylation of 1H-Indazole and 1H-7-Azaindazole
Molecules, 2020 The C3 direct arylation of 1H-indazole and 1H-7-azaindazole has been a significant challenge due to the lack of the reactivity at this position. In this paper, we describe a mild and an efficient synthesis of new series of C3-aryled 1H-indazoles and C3 ...
Khadija Gambouz +7 more
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The C3-H Bond Functionalization of Quinoxalin-2(1H)-Ones With Hypervalent Iodine(III) Reagents
Frontiers in Chemistry, 2020 The modification of quinoxalin-2(1H)-ones via direct C-H bond functionalization has begun to receive widespread attention, due to quinoxalin-2(1H)-one derivatives' various biological activities and pharmaceutical properties. This mini review concentrates
Yushi Tan +4 more
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Journal of Chemistry, 2013 Phosphine-free palladium-catalyzed direct arylation of 2-phenyl-imidazo[1,2-a]pyridine has been developed with the concept of using silver(I) carboxylate.
Sridevi Kona +3 more
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Nickel-catalyzed switchable arylative/endo-cyclization of 1,6-enynes
Nature CommunicationsCarbo- and heterocycles are frequently used as crucial scaffolds in natural products, fine chemicals, and biologically and pharmaceutically active compounds.
Wenfeng Liu +4 more
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Direct arylation catalysis with chloro[8-(dimesitylboryl)quinoline-κN]copper(I)
Beilstein Journal of Organic Chemistry, 2016 We report direct arylation of arylhalides with unactivated sp2 C–H bonds in benzene and naphthalene using a copper(I) catalyst featuring an ambiphilic ligand, (quinolin-8-yl)dimesitylborane.
Sem Raj Tamang, James D. Hoefelmeyer
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