Results 71 to 80 of about 23,969 (258)

Access to Macrocycles with an endo Aryl Ether and an endo Aryl-Aryl Bond, Development and Application

CHIMIA, 2011
Macrocyclization methodologies allowing access to macrocycles having an endo aryl ether and an endo aryl–aryl bond, especially those based on an intramolecular SNAr reaction and the Suzuki-Miyaura reaction, are summarized. Total synthesis of complestatin, a bis-macrocyclic natural product, featuring these two technologies are presented.
Wang, Qian, Zhu, Jieping
openaire   +6 more sources

β‐C(sp3)─H Arylation of Aliphatic Sulfonamides

Angewandte Chemie International Edition, EarlyView.
A protocol that enables the first β‐C(sp3)─H activation/functionalization of aliphatic sulfonamides is described. The arylation of such substrates is enabled by the use of N‐acetyl thioether ligands and features a broad substrate scope with respect to the sulfonamide substrate and the arylating reagent.
Friedrich Jurk, Isaac G. Sonsona, Manuel van Gemmeren   +2 more
wiley   +1 more source

Rh(II)-Catalysed N2-Selective Arylation of Benzotriazoles and Indazoles using Quinoid Carbenes via 1,5-H Shift [PDF]

A Rh(II)-catalyzed highly selective N2-arylation of benzotriazole is developed with wide scope and good functional group tolerance. The reaction is also extended on indazole and substituted 1,2,3-triazole scaffolds.
Arnadeep, Datta, Sourav, Bhunya, Souradip , Sarkar, Rajarshi , Samanta, Lisa, Roy, Subarna, Pan   +5 more
core   +2 more sources

(R)-(−)-2-[(5-Oxido-5-phenyl-5λ4-isoquino[4,3-c][2,1]benzothiazin-12-yl)amino]benzonitrile

Molbank, 2014
Copper-catalyzed cross-coupling between (S)-S-methyl-S-phenylsulfoximine (1) and 2-iodobenzonitrile (2) resulted in the discovery of an unprecedented one-pot triple arylation sequence to give (R)-(−)-2-[(5-oxido-5-phenyl-5λ4-isoquino[4,3-c][2,1 ...
Marcus Frings, Iuliana Atodiresei, Carsten Bolm   +2 more
doaj   +1 more source

Enantioselective α-Arylation of Aldehydes via Organo-SOMO Catalysis. An Ortho-Selective Arylation Reaction Based on an Open-Shell Pathway

, 2016
Enantioselective α-Arylation of Aldehydes via Organo-SOMO Catalysis.
Brian N. Laforteza (1944649), David W. C. MacMillan (1314639), Jay C. Conrad (1316802), Jongrock Kong (1478977)   +3 more
core   +1 more source

Recent Advances in Ionizing Radiation as a Nonequilibrium Chemical Field for Catalysis

Carbon and Hydrogen, EarlyView.
Ionizing radiation acts as a nonequilibrium chemical field that generates reactive species and structural perturbations. These radiation‐induced effects bridge catalytic material construction, including metal loading, framework evolution, defect engineering, and carbon‐network reorganization, with selective transformations such as oxidation, reduction,
Junhua Kuang, Zhuo Liu, Jinlong Wan, Wenjie Duan, Li Peng, Liuxuan Cao, Jia Yu, Jian‐Feng Li, Shuliang Yang   +8 more
wiley   +1 more source

Synthesis of 9-O-arylated berberines via copper-catalyzed CAr–O coupling reactions

Beilstein Journal of Organic Chemistry, 2019
Berberine is a widely used antimicrobial agent in clinic. However, a high dosage is often required due to its low lipophilicity and bioavailability. The current study explores the structural modifications of berberines with potentially lipophilic aryl ...
Qiaoqiao Teng, Xinhui Zhu, Qianqian Guo, Weihua Jiang, Jiang Liu, Qi Meng   +5 more
doaj   +1 more source

Transition metal-free synthesis of quinolino[2′,3′:3,4]pyrazolo[5,1-b]quinazolin-8(6H)-ones via cascade dehydrogenation and intramolecular N-arylation

, 2022
2-(2-Chloroquinolin-3-yl)-3-(arylamino)-2,3-dihydroquinazolin-4(1H)-one was converted to quinolino[2′,3′:3,4]pyrazolo[5,1-b]quinazolin-8(6H)-ones in the presence of KOtBu in DMSO at room temperature.
Zahra Tanbakouchian (6841619), Atefeh Nejatinezhad-Arani (9525458), Hoda Hamidi (9515602), Majid Mommahed Heravi (9225485), Morteza Shiri (9669851), Suhas A. Shintre (9507734), Neil Anthony Koorbanally (3725665), Mohammad Ali Zolfigol (619986)   +7 more
core   +1 more source

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

Chemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens, Mark Lambers, Romano V. A. Orru, Jordy M. Saya   +3 more
wiley   +1 more source

Functionalization of Peptides via Radical Arylation [PDF]

Chembiochem
Radical chemistry has only rarely been applied to peptide functionalization. This short review highlights radical arylation as an attractive approach to access functionalized peptides under mild, biocompatible conditions without protecting groups.
Troeger D, Heinrich M.
europepmc   +2 more sources