Results 41 to 50 of about 629 (164)
Journal of Chemistry, Volume 2017, Issue 1, 2017., 2017 Recent drug discovery efforts are highly focused towards identification, design, and synthesis of small molecules as anticancer agents. With this aim, we recently designed and synthesized novel compounds with high efficacy and specificity for the treatment of breast tumors.
Vincenza Barresi +8 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 13, 14 July 2026.Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira +8 more
wiley +1 more source
Synthesis of Some New Thiazole Derivatives and Their Biological Activity Evaluation
Journal of Chemistry, Volume 2015, Issue 1, 2015., 2015 New 2‐(4‐arylpiperazine‐1‐yl)‐N‐[4‐(2‐(4‐substituted phenyl)thiazol‐4‐yl)phenyl]acetamide derivatives were synthesized and evaluated for their antimicrobial and anticholinesterase activities. Acetylcholinesterase inhibitory activities of the compounds were found weak contrary to expectations. It is unlikely that antifungal activity of the compounds was
Leyla Yurttaş +4 more
wiley +1 more source
Exemplary pharmacophore hypothesis selected for arylpiperazines with classical amide fragment.
, 2013 Exemplary pharmacophore hypothesis selected for arylpiperazines with classical amide fragment mapping 6 out of 10 cluster representatives. The model fit 462 of the 533 compounds (87%) in the cluster. The feature abbreviations are: hydrogen-bond donor – D,
Stefan Mordalski (499181) +6 more
core +1 more source
European Journal of Inorganic Chemistry, Volume 29, Issue 17, 17 June 2026.Here, we describe new Cu(I)/Cu(II) complexes based on arylated tren ligands and investigate their reactivity toward O2 and peroxides. Low‐temperature–stopped flow studies revealed the formation of transient copper–oxygen species, including superoxido, hydroperoxido, and alkylperoxido intermediates.
Chiara Eleonora Campi +2 more
wiley +1 more source
Synthesis and Preliminary Pharmacological Evaluation of 2-[4-(Aryl substituted) piperazin-1-yl]-Nphenylacetamides: Potential Antipsychotics [PDF]
, 2011 Purpose: Arylpiperazines have been recognized as the largest and most diverse class of compounds exerting actions on the central nervous system with strong affinity for serotonin and dopamine receptors.
Singh, R +5 more
core +4 more sources
Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry
ChemistryOpen, Volume 15, Issue 1, January 2026.Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten +5 more
wiley +1 more source
Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application
Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade +4 more
wiley +1 more source
Molecules, 2019 Trazodone, a well-known antidepressant drug widely used throughout the world, works as a 5-hydroxytryptamine (5-HT2) and α1-adrenergic receptor antagonist and a serotonin reuptake inhibitor.
Jolanta Jaśkowska +5 more
doaj +1 more source
ChemMedChem, Volume 20, Issue 15, August 2, 2025.The synthesis of a new series of 4,5‐dihydrothiazol‐2‐ylphenylpiperazine derivatives as serotoninergic ligands is described and tested for their affinity toward 5‐HT1A, 5‐HT2A,and 5‐HT2C and selected for further in vivo assays to determine their functional activity. The pharmacological studies highlight that among the developed derivatives, FG‐7 and FG‐
Giorgia Andreozzi +18 more
wiley +1 more source