Results 51 to 60 of about 605 (157)

Structure-retention relationship study of arylpiperazines by linear multivariate modeling

, 2010
A quantitative structure retention relationship study has been performed to correlate the retention of 33 newly synthesized arylpiperazines with their molecular characteristics, using thin-layer chromatography.
Andrić, Filip, Deana Andrić, Andrić, Deana, Živoslav Lj Tešić, Trifković, Jelena, Petar Ristivojević, Milojković-Opsenica, Dušanka, Tešić, Živoslav Lj., Filip Andrić, Ristivojević, Petar, Jelena Trifković, Dušanka M. Milojković-Opsenica   +11 more
core   +1 more source

Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D₃ and Serotonin 5-HT_1A and 5-HT_2A Receptors

, 2016
As a continuation of our efforts to develop innovative ligands for D3, 5-HT1A, and 5-HT2A receptors with low propensity to block hERG channels, we propose a series bishetero(homo)arylpiperazines 5a−m as novel and potent multifunctional ligands ...
Karin Sandager-Nielsen (1714315), Egeria Guarino (1871641), Francesco Trotta (1714273), Nausicaa Orteca (1338516), Vinod Kumar (48743), Caterina Fattorusso (1338522), Giuseppe Campiani (1714282), Marco Persico (1338504), Silvia Franceschini (1714306), Giuseppe Borrelli (2055877), Ettore Novellino (333902), Jorgen Scheel-Kruger (1714300), Stefania Butini (1714288), Thomas Amos Jacobsen (2289487), Kim Madsen (2289490), Sandra Gemma (1714309), Isabella Fiorini (2012737)   +16 more
core   +1 more source

Ionization constants and partition coefficients of 1-arylpiperazine derivatives

Journal of Pharmacy and Pharmacology, 1985
AbstractThe ionization constant (pKa and liposolubilities (log P) of fourteen 1-arylpiperazines were determined by n-octanol/buffer partition. pKa varied little across the entire series. Log P values ranged from less than 1 to about 2 for the highly lipophilic derivatives of the preset series.
S, Caccia, M H, Fong, R, Urso
openaire   +2 more sources

5-HT_1A- versus D₂-Receptor Selectivity of Flesinoxan and Analogous N ⁴-Substituted N ¹-Arylpiperazines

, 2016
We investigated the structural requirements for high 5-HT1A affinity of the agonist flesinoxan and its selectivity versus D2 receptors. For this purpose a series of arylpiperazine congeners of flesinoxan were synthesized and evaluated for their ability ...
Martin Th. M. Tulp (2665003), Anthony L. Spek (1913542), Nora Veldman (2955354), Piet J. Standaar (3019230), Adriaan P. IJzerman (195167), Chris G. Kruse (1568176), Wilma Kuipers (3019227), Ineke van Wijngaarden (3019233)   +7 more
core   +1 more source

Synthesis and pharmacological evaluation of N-{4-[2-(4-arylpiperazin-1- yl)ethyl]phenyl} arylamides [PDF]

, 2019
Serotonin 5HT1a receptor belongs to a class of G-protein coupled receptors. It serves as a potential target for neurological disorders such as depression, anxiety etc.
Dukic-Stefanovic, Sladjana, Kostić-Rajačić, Slađana, Andrić, Deana, Penjišević, Jelena, Spalholz, Tina, Burst, Peter   +5 more
core   +3 more sources

Mixed dopaminergic/serotonergic properties of several 2-substituted 4-[2-(5-benzimidazole)ethyl]-1-arylpiperazines

, 1998
A series of substituted 4-[2-(5-benzimidazole)ethyl]-arylpiperazines was synthesized by introducing different substituents into position 2 of benzimidazole ring of 4-[2-(N,N-di-n-propylamino)ethyl]-1,2-diaminobenzenes.
Kostić Rajačić, Slađana, Joksimovic, J, Šoškić, Vukić   +2 more
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Discovery and Preliminary Structure–Activity Relationship of Arylpiperazines as Novel, Brain-Penetrant Antiprion Compounds

, 2016
Creutzfeldt-Jakob disease and kuru in humans, BSE in cattle, and scrapie in sheep are fatal neurodegenerative disorders. Such illnesses are caused by the conversion and accumulation of a misfolded pathogenic isoform (termed PrPSc) of a normally benign ...
Stanley B. Prusiner (190817), Zhe Li (219258), B. Michael Silber (1936948), Joel R. Gever (1936945), Kartika Widjaja (1936942), Satish Rao (126033)   +5 more
core   +1 more source

Design Strategies, Chemistry and Therapeutic Insights of Multi-target Directed Ligands as Antidepressant Agents. [PDF]

Curr Neuropharmacol, 2022
Singh K, Bhatia R, Kumar B, Singh G, Monga V.   +4 more
europepmc   +1 more source

Binding of Arylpiperazines, (Aryloxy)propanolamines, and Tetrahydropyridylindoles to the 5-HT_1A Receptor:  Contribution of the Molecular Lipophilicity Potential to Three-Dimensional Quantitative Structure−Affinity Relationship Models

, 2016
A set of 280 5-HT1A receptor ligands were selected from available literature data according to predefined criteria and subjected to three-dimensional quantitative structure−affinity relationship analysis using comparative molecular field analysis.
Pierre-Alain Carrupt (522894), Philippe Schambel (1854316), Bernard Testa (2470240), Patrick Gaillard (3017337)   +3 more
core   +1 more source