Results 71 to 80 of about 629 (164)

Discovery and Preliminary Structure–Activity Relationship of Arylpiperazines as Novel, Brain-Penetrant Antiprion Compounds

, 2016
Creutzfeldt-Jakob disease and kuru in humans, BSE in cattle, and scrapie in sheep are fatal neurodegenerative disorders. Such illnesses are caused by the conversion and accumulation of a misfolded pathogenic isoform (termed PrPSc) of a normally benign ...
Stanley B. Prusiner (190817), Zhe Li (219258), B. Michael Silber (1936948), Joel R. Gever (1936945), Kartika Widjaja (1936942), Satish Rao (126033)   +5 more
core   +1 more source

Probing antibacterial drugs for Fusobacterium nucleatum subsp. nucleatum ATCC 25586 targeting UDP-N-acetylglucosamine 1-carboxyltransferase. [PDF]

J Adv Pharm Technol Res, 2023
Saputri D, Mubarak Z, Mudatsir M, Setyawati I, Setiawan AG, Abrar M.   +5 more
europepmc   +1 more source

Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers. [PDF]

J Enzyme Inhib Med Chem, 2021
Wang C, Li Y, Liu Z, Wang Z, Liu Z, Man S, Zhang Y, Bao K, Wu Y, Guan Q, Zuo D, Zhang W.   +11 more
europepmc   +1 more source

4-[ω-[4-Arylpiperazin-1-yl]alkoxy]phenyl)imidazo[1,2-a]pyridine Derivatives:  Fluorescent High-Affinity Dopamine D₃ Receptor Ligands as Potential Probes for Receptor Visualization

, 2007
Sixteen long-chain arylpiperazines bearing the fluorescent moiety 2-phenylimidazo[1,2-a]pyridine were synthesized as fluorescent dopamine D3 receptors ligands (385 nM Ki 3 compounds 15a and 19a (Ki = 1.6 and 0.72 nM, respectively) showed good Stokes ...
Enza Lacivita (548487), Elena Passafiume (8660112), Marialessandra Contino (2060335), Francesco Berardi (1816747), Nicola A. Colabufo (445449), Marcello Leopoldo (548488), Roberto Perrone (1816750)   +6 more
core   +1 more source

Synthesis, bioactivity, and molecular docking of novel arylpiperazine derivatives as potential AR antagonists. [PDF]

Front Chem, 2022
Qi Y, Chen H, Chen S, Shen J, Li J.
europepmc   +1 more source

Influence of cellular lipid content on influenza A virus replication. [PDF]

Arch Virol, 2020
Limsuwat N, Boonarkart C, Phakaratsakul S, Suptawiwat O, Auewarakul P.   +4 more
europepmc   +1 more source

Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis. [PDF]

Front Oncol, 2021
Hipólito A, Martins F, Mendes C, Lopes-Coelho F, Serpa J.   +4 more
europepmc   +1 more source

Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter(SERT)and 5-HT1A receptors

, 2005
A new generation of antidepressant agents could be represented by compounds with mixed activity as serotonin transporter (SERT) inhibitors and 5-HT(1A) receptor antagonists.
COLABUFO, Nicola Antonio, LEOPOLDO, Marcello, PERRONE, Roberto, TORTORELLA V., BERARDI, Francesco, LARIZZA C., LACIVITA, ENZA   +6 more
core  

σ₂ Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach. [PDF]

Molecules, 2021
Abatematteo FS, Niso M, Lacivita E, Abate C.   +3 more
europepmc   +1 more source

Research progress on antitumor activity of XRP44X and analogues as microtubule targeting agents. [PDF]

Front Chem, 2023
Wang C, Shi L, Yang S, Chang J, Liu W, Zeng J, Meng J, Zhang R, Xing D.   +8 more
europepmc   +1 more source