Results 61 to 70 of about 629 (164)

Binding of Arylpiperazines, (Aryloxy)propanolamines, and Tetrahydropyridylindoles to the 5-HT_1A Receptor:  Contribution of the Molecular Lipophilicity Potential to Three-Dimensional Quantitative Structure−Affinity Relationship Models

, 2016
A set of 280 5-HT1A receptor ligands were selected from available literature data according to predefined criteria and subjected to three-dimensional quantitative structure−affinity relationship analysis using comparative molecular field analysis.
Pierre-Alain Carrupt (522894), Philippe Schambel (1854316), Bernard Testa (2470240), Patrick Gaillard (3017337)   +3 more
core   +1 more source

Structure-retention relationship study of arylpiperazines by linear multivariate modeling

, 2010
A quantitative structure retention relationship study has been performed to correlate the retention of 33 newly synthesized arylpiperazines with their molecular characteristics, using thin-layer chromatography.
Andrić, Filip, Deana Andrić, Andrić, Deana, Živoslav Lj Tešić, Trifković, Jelena, Petar Ristivojević, Milojković-Opsenica, Dušanka, Tešić, Živoslav Lj., Filip Andrić, Ristivojević, Petar, Jelena Trifković, Dušanka M. Milojković-Opsenica   +11 more
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Aryl- and Heteroaryl Substituted Tandospirones as Possible Antidepressant Drugs

, 2015
Nowadays, heterocyclic compounds which have a nitrogen atom on the structure, such as pharmacological products, pesticides and antimicrobials can be demonstrated by biologically-active groups that serve the pharmaceutical industry and they are still ...
Günkara, Ömer Tahir, Kulu, Irem, Öcal, Nuket   +2 more
core   +2 more sources

Opioid Receptor Modulators with a Cinnamyl Group

, 2017
To obtain selective and potent opioid receptor ligands, we synthesized dehydro derivatives of alvimopan and found compound (28f), a selective but modest affinity MOR antagonist weaker than alvimopan (1).
Sekar, Kanagaraj, Prem N. Yadav, Kanagaraj Sekar, Biswas, Ansuman, Michael, Daliah, Dogra, Shalini, Daliah Michael, Kuppuswamy Nagarajan, Naidu, N. Venkata Subba, Umrao, Deepmala, Ravilla, Lokesh, Shalini Dogra, Deepmala Umrao, Nagarajan, Kuppuswamy, Lokesh Ravilla, Yadav, Prem N, Ansuman Biswas, N. Venkata subba Naidu   +17 more
core   +1 more source

Design Strategies, Chemistry and Therapeutic Insights of Multi-target Directed Ligands as Antidepressant Agents. [PDF]

Curr Neuropharmacol, 2022
Singh K, Bhatia R, Kumar B, Singh G, Monga V.   +4 more
europepmc   +1 more source

Discovery and Preliminary Structure–Activity Relationship of Arylpiperazines as Novel, Brain-Penetrant Antiprion Compounds

, 2013
Prion diseases are a group of fatal neurodegenerative disorders that include Creutzfeldt-Jakob disease (CJD) and kuru in humans, BSE in cattle, and scrapie in sheep.
Gever, Joel R, Prusiner, Stanley B, Satish Rao, Li, Zhe, B. Michael Silber, Stanley B. Prusiner, Rao, Satish, Joel R. Gever, Zhe Li, Widjaja, Kartika, Kartika Widjaja, Silber, B Michael   +11 more
core   +1 more source

Mixed dopaminergic/serotonergic properties of several 2-substituted 4-[2-(5-benzimidazole)ethyl]-1-arylpiperazines

, 1998
A series of substituted 4-[2-(5-benzimidazole)ethyl]-arylpiperazines was synthesized by introducing different substituents into position 2 of benzimidazole ring of 4-[2-(N,N-di-n-propylamino)ethyl]-1,2-diaminobenzenes.
Kostić Rajačić, Slađana, Joksimovic, J, Šoškić, Vukić   +2 more
core   +1 more source

Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria. [PDF]

Antibiotics (Basel), 2023
Compagne N, Vieira Da Cruz A, Müller RT, Hartkoorn RC, Flipo M, Pos KM.   +5 more
europepmc   +1 more source

Conformational analysis and theoretical quantitative size and shape-affinity relationships of N-4-protonated N-1-arylpiperazine 5-HT1A serotoninergic ligands

, 1997
Conformational analysis for 24 arylpiperazines in their neutral and N-4-protonated forms has been performed in the AM1 framework. Both these derivatives and eight reference compounds considered in this study are ligands of the 5-HT1A serotoninergic ...
F. Fanelli, COCCHI, Marina, FANELLI, Francesca, M.C. Menziani, P.G. De Benedetti, M. Cocchi, MENZIANI, Maria Cristina, DE BENEDETTI, Pier Giuseppe   +7 more
core   +1 more source