Results 91 to 100 of about 605 (157)

Uncovering the unique characteristics of different groups of 5-HT_5AR ligands with reference to their interaction with the target protein. [PDF]

Pharmacol Rep
Kordylewski SK, Bugno R, Bojarski AJ, Podlewska S.   +3 more
europepmc   +1 more source

The Universal 3D QSAR Model for Dopamine D₂ Receptor Antagonists. [PDF]

Int J Mol Sci, 2019
Zięba A, Żuk J, Bartuzi D, Matosiuk D, Poso A, Kaczor AA.   +5 more
europepmc   +1 more source

Therapeutic Role of Heterocyclic Compounds in Neurodegenerative Diseases: Insights from Alzheimer's and Parkinson's Diseases. [PDF]

Neurol Int
Puranik N, Song M.
europepmc   +1 more source

Multi-Target Approach for Drug Discovery against Schizophrenia. [PDF]

Int J Mol Sci, 2018
Kondej M, Stępnicki P, Kaczor AA.
europepmc   +1 more source

New pyrimidine derivatives as potential agents against hepatocellular carcinoma: design, synthesis, and <i>in vitro</i> and <i>in vivo</i> biological evaluations. [PDF]

Front Pharmacol
Bertrand J, Montorfano I, Pérez-Castro R, Valdés-Valdés R, Romero J, Delgado T, Brito I, Santibáñez JF, Cabrera AR, Vieytes MP, Echeverría J, Salas CO, Echeverría C.   +12 more
europepmc   +1 more source

Excavating Precursors from Herb Pairs <i>Polygala tenuifolia</i> and <i>Acori tatarinowii</i>: Synthesis and Anticonvulsant Activity Evaluation of 3,4,5-Trimethoxycinnamic Acid (TMCA) Piperazine Amide Derivatives. [PDF]

Pharmaceuticals (Basel)
Zhao Z, Lei M, Wang Y, Bai Y, Qiao H.
europepmc   +1 more source

Rhodanine-Piperazine Hybrids as Potential VEGFR, EGFR, and HER2 Targeting Anti-Breast Cancer Agents. [PDF]

Int J Mol Sci
Szczepański J, Khylyuk D, Korga-Plewko A, Michalczuk M, Mańdziuk S, Iwan M, Trotsko N.   +6 more
europepmc   +1 more source

A Series of Novel 1-H-isoindole-1,3(2H)-dione Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: In Silico, Synthesis and In Vitro Studies. [PDF]

Molecules
Krzyżak E, Marciniak A, Szkatuła D, Jankowska KA, Dobies N, Kotynia A.   +5 more
europepmc   +1 more source

Solution phase combinatorial synthesis of arylpiperazines

Tetrahedron Letters, 1997
A solution phase combinatorial synthesis of aryl piperazines 1 and 2 is described based on the S(N)Ar reaction and Schotten-Baumann acylation. The use of excess reagent is allowed and pure arylpiperazines 1 and 2 were obtained by simple acid/base washing.
Neuville, Luc, Zhu, Jieping
openaire   +2 more sources

Bioactive conformation of 1-arylpiperazines at central serotonin receptors

Journal of Medicinal Chemistry, 1985
A number of 1-arylpiperazines have been characterized as direct-acting serotonin agonists. Conformational parameters of this class that may affect receptor recognition and binding have been examined through the analysis of X-ray data and synthesis of rigid analogues.
J R, Huff, S W, King, W S, Saari, J P, Springer, G E, Martin, M, Williams   +5 more
openaire   +3 more sources