Results 101 to 110 of about 310 (140)

Structure–retention relationship study of arylpiperazines by linear multivariate modeling

Journal of Separation Science, 2010
AbstractA quantitative structure–retention relationship study has been performed to correlate the retention of 33 newly synthesized arylpiperazines with their molecular characteristics, using thin‐layer chromatography. Principal component analysis followed by multiple linear regression (MLR), principal component regression (PCR) and partial least ...
Trifković, Jelena, Andrić, Filip, Ristivojević, Petar, Andrić, Deana, Tešić, Živoslav Lj., Milojković-Opsenica, Dušanka   +5 more
openaire   +3 more sources

Synthesis and structure of 1-difluoronitroacetyl-4-arylpiperazines

Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1988
1-Difluoronitroacetyl-4-arylpiperazines were synthesized. The molecular structure of 1-difluoronitroacetyl-4-(p-fluorophenyl)piperazine was established by x-ray diffraction structural analysis.
V. K. Brel', M. V. Dodonov, A. N. Chekhlov, I. V. Martynov   +3 more
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Parallel Synthesis of N‐Arylpiperazines Using Polymer‐Assisted Reactions.

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Matthew A.J. Duncton, Jonathan R.A. Roffey, Richard J. Hamlyn, David R. Adams   +3 more
openaire   +1 more source

Exploration of N-arylpiperazine Binding Sites of D2 Dopaminergic Receptor

Mini-Reviews in Medicinal Chemistry, 2015
The crystal structures of the D3 dopamine receptor and several other G-protein coupled receptors (GPCRs) were published in recent times. Those 3D structures are used by us and other scientists as a template for the homology modeling and ligand docking analysis of related GPCRs.
Šoškić, Vukić, Šukalović, Vladimir, Kostić Rajačić, Slađana   +2 more
openaire   +3 more sources

Benzenesulfenamides as antihypertensive agents. Substituted piperidine and 1-arylpiperazine derivatives

Journal of Medicinal Chemistry, 1980
The synthesis and antihypertensive activity of several piperidinebenzenesulfenamides related to the previously reported potent hypotensive agents 1 and a series of 1-arypiperazine-4-benzenesulfenamides 7 are described. A number of the latter compounds exhibit marked antihypertensive properties.
S S, Klioze, R C, Allen, J C, Wilker, D L, Woodward   +3 more
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SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2007
The SAR of over 50 derivatives of octahydrobenzo[g]quinoline (obeline)-type somatostatin sst(1) receptor antagonist 1 is presented, focusing on the modification of its arylpiperazine moiety. Sst(1) affinities in this series cover a range of five orders of magnitude with the best derivatives displaying subnanomolar sst(1) affinities and >10,000-fold ...
Konstanze, Hurth, Albert, Enz, Philipp, Floersheim, Conrad, Gentsch, Daniel, Hoyer, Daniel, Langenegger, Peter, Neumann, Paul, Pfäffli, Dieter, Sorg, Robert, Swoboda, Annick, Vassout, Thomas, Troxler   +11 more
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Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands

Journal of Medicinal Chemistry, 1988
Although simple arylpiperazines are commonly considered to be moderately selective for 5-HT1B serotonin binding sites, N4-substitution of such compounds can enhance their affinity for 5-HT1A sites and/or decrease their affinity for 5-HT1B sites. A small series of 4-substituted 1-arylpiperazines was prepared in an attempt to develop agents with high ...
R A, Glennon, N A, Naiman, R A, Lyon, M, Titeler   +3 more
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Conformational analysis of 1‐arylpiperazines and 4‐arylpiperidines

Recueil des Travaux Chimiques des Pays-Bas, 1993
AbstractA conformational analysis of 1‐arylpiperazines and 4‐arylpiperidines is presented using molecular‐mechanics and semi‐empirical calculations. It has been found that electronic effects of substituents on the aryl ring determine the conformational behaviour of 1‐arylpiperazines. Steric effects play a minor role.
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SODIUM CHANNEL BLOCKING AND ANTIARRHYTHMIC ACTIONS OF THE NOVEL ARYLPIPERAZINE RSD992

Pharmacological Research, 2002
Bolus doses (4-128 micromolkg(-1)) and infusions (2-32 micromolkg(-1)min(-1)) of the novel arylpiperazine drug RSD992 produced bradycardia in rats and guinea pigs but had minimal effect on ECG variables. RSD992 (2-32 micromolkg(-1)min(-1)) increased threshold current (I(T)) for induction of extra-systoles and induction of sustained ventricular ...
Eric S, Hayes, Michael K, Pugsley, Alan L, Goldin, Michael J A, Walker   +3 more
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Arylpiperazine derivatives as serotoninergic ligands

2009
Serotonin is a neuromediator well known for its implication in mood regulation, anxiety, depression,insomnia as well as in normal human function such as sleep, sexual activity and appetite and recently it was demonstrated its involvement in the proliferation of human tumor cells.
FIORINO F, DE ANGELIS F, SEVERINO B, PERISSUTTI E, FRECENTESE F, ESPOSITO A, MASSARELLI, PAOLA, RENNER C, SANTAGADA V, CALIENDO G.   +9 more
openaire   +1 more source