Results 121 to 130 of about 629 (164)

Spatial structure in the N-arylpiperazine series

Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1987
In the compounds examined, the angle of rotation of the plane of the aromatic ring relative to the unshared electron pair of the nitrogen atom is close to orthogonal, but in the o-fluoro-compound it is smaller.
I. Yu. Strobykina, V. E. Kataev, A. N. Vereshchagin, I. V. Galyametdinova, V. D. Akamsin   +4 more
openaire   +1 more source

Novel arylpiperazines as selective α1-adrenergic receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2000
A novel series of arylpiperazines has been synthesized and identified as antagonists of alpha1a adrenergic receptor (alpha1a-AR) implicated in benign prostatic hyperplasia. These compounds selectively bind to membrane bound alpha1a-AR with K(i)s as low as 0.66 nM.
X, Li, W V, Murray, L, Jolliffe, V, Pulito   +3 more
openaire   +2 more sources

Intraocular Pressure Lowering Effects of Novel Arylpiperazine Derivatives

Journal of Ocular Pharmacology and Therapeutics, 1998
Arylpiperazine derivatives were synthesized and investigated in this study. Two animal models, including an intraocular pressure (IOP) recovery method and an alpha-chymotrypsin-induced glaucoma model, were used to determine the ocular pharmacological effects of the arylpiperazine derivatives.
C H, Chiang, T J, Chang, D W, Lu, A R, Lee   +3 more
openaire   +2 more sources

Modeling of the D₂ Dopamine Receptor Arylpiperazine Binding Site for 1‐{2‐[5‐(1H‐Benzimidazole‐2‐thione)]ethyl}‐4‐arylpiperazines.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Šukalović, Vladimir, Zlatović, Mario, Andrić, Deana, Roglić, Goran, Kostić Rajačić, Slađana, Šoškić, Vukić   +5 more
openaire   +4 more sources

The Interactions of the 5-HT3 Receptor with Arylpiperazine, Tropane, and Quinuclidine Ligands

Current Topics in Medicinal Chemistry, 2002
The serotonin 5-HT(3) receptor subtype is unique among the receptors for this neurotransmitter because it has been demonstrated to be a ligand-gated ion channel capable of mediating rapid intercellular communication. This review covers the authors work performed during more than a decade in the development of 5-HT(3) receptor ligands belonging to the ...
Cappelli, Andrea, Anzini, Maurizio, Vomero, Salvatore, Mennuni, L., Makovec, F., Hamon, M., De Benedetti, P. G., Menziani, M. C.   +7 more
openaire   +5 more sources

Arylpiperazine derivatives as serotoninergic ligands

2009
Serotonin is a neuromediator well known for its implication in mood regulation, anxiety, depression,insomnia as well as in normal human function such as sleep, sexual activity and appetite and recently it was demonstrated its involvement in the proliferation of human tumor cells.
FIORINO F, DE ANGELIS F, SEVERINO B, PERISSUTTI E, FRECENTESE F, ESPOSITO A, MASSARELLI, PAOLA, RENNER C, SANTAGADA V, CALIENDO G.   +9 more
openaire   +1 more source

Antihypertensive activity of 1-dimethylphosphinylmethyl-4-arylpiperazines

Journal of Medicinal Chemistry, 1974
E J, Glamkowski, J, Strupczewski, E, Wolf, D L, Woodward   +3 more
openaire   +2 more sources

SMILES-Based QSAR Model for Arylpiperazines as High-Affinity 5-HT1A Receptor Ligands Using CORAL

European Journal of Pharmaceutical Sciences, 2013
Andrey Toropov, Aleksandar Veselinović, Goran Nikolić   +2 more
exaly  

Arylpiperazines Displaying Preferential Potency Against Chloroquine-Resistant Strains of the Malaria Parasite Plasmodium falciparum

Biochemical Pharmacology, 2005
Kelly Chibale, Hagai Ginsburg, Miriam Krugliak   +2 more
exaly  

Arylpiperazines With N-Acylated Amino Acids as 5-HT1A Receptor Ligands

Bioorganic and Medicinal Chemistry Letters, 2006
Beata Duszyńska, Mathéo Berthet, Paweł Zajdel   +2 more
exaly