Results 111 to 120 of about 310 (140)

Synthesis, biological evaluation and SAR of naftopidil-based arylpiperazine derivatives

Bioorganic & Medicinal Chemistry Letters, 2018
For the development of potential anti-prostate cancer agents, 24 kinds of novel naftopidil-based arylpiperazine derivatives have been synthesized and characterized by spectroscopic methods. Their antitumor activities were evaluated against several classical prostate cancer cell lines including PC-3, LNCaP, and DU145. Among all the compounds, 9, 13, 17,
Hong, Chen, Cai-Lu, Wang, Tao, Sun, Zhan, Zhou, Jiang-Xiu, Niu, Xiu-Mei, Tian, Mu, Yuan   +6 more
openaire   +2 more sources

Fragmentation of N-Boc arylpiperazines under basic conditions

Tetrahedron Letters, 1997
N-Boc arylpiperazines 1a-c under basic conditions (sec-Buli, TMEDA, THF) undergo ring opening fragmentation to yield arylethylenediamines 2a-c, 4a-c at low temperature and arylimidazolidinones 5a-c at higher temperature.
Fabrice Garrido, André Mann, Camille-Georges Wermuth   +2 more
openaire   +1 more source

ChemInform Abstract: Solution Phase Combinatorial Synthesis of Arylpiperazines.

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
L. NEUVILLE, J. ZHU
openaire   +1 more source

Antihypertensive activity of 1-dimethylphosphinylmethyl-4-arylpiperazines

Journal of Medicinal Chemistry, 1974
E J, Glamkowski, J, Strupczewski, E, Wolf, D L, Woodward   +3 more
openaire   +2 more sources

Antimalarials based on the arylpiperazine privileged substructure

2014
Based on a previous study, arylpiperazines (2-chlorophenylpiperazine, 2-ethoxyphenylpiperazine and phenylpiperazine) were found to be significantly more potent against the chloroquine-resistant (K1) strain than against the chloroquine-sensitive(DIO) strain.
openaire   +1 more source

The in vivo and in vitro protective role of arylpiperazine in neuroinflammation

European Neuropsychopharmacology, 2016
Z. Stanojevic, J. Tošić, S. Vidičević, M. Popović, S. Petričević, N. Nedeljković, M. Jovanović, J.A. Isaković, V. Trajković   +8 more
openaire   +2 more sources

Synthesis and pharmacological properties of N-arylpiperazine-N'-alkylindanes.

Polish journal of pharmacology and pharmacy, 1985
Ten new compounds, N-aryl substituted piperazinealkylindanes, have been synthesized. The most active one 1-(2-[4-(3-chlorophenyl)-1-piperazinyl]-ethyl)-indane (compound 9), displayed evident central serotoninolytic properties in the 5-hydroxytryptamine (5-HTP) head twitch test in mice, as well as in the tryptamine convulsions test and the quipazine ...
S, Misztal, E, Chojnacka-Wójcik, P, Bartyzel, A, Moskal, E, Tatarczyńska, B, Wiczyńska, A, Lewandowska   +6 more
openaire   +1 more source

Arylpiperazine Process Research: Past and Present

Proceedings of the Symposium on Progress in Organic Reactions and Syntheses, 2011
Torisawa, Yasuhiro, Hangui, Masahiko, Takahashi, Yasuhiro   +2 more
openaire   +1 more source

Efficient Access to Pharmacologically Relevant 2-Arylpiperazines

Synfacts, 2023
openaire   +1 more source

SMILES-based QSAR model for arylpiperazines as high-affinity 5-HT1A receptor ligands using CORAL

European Journal of Pharmaceutical Sciences, 2013
Aleksandar M Veselinovic, Andrey A Toropov, Göran M Nikolic   +2 more
exaly