Results 21 to 30 of about 5,708 (209)

Distinct effects of adjuvants on B cell responses to protein or polysaccharide antigens contained in glycoconjugate vaccines [PDF]

Frontiers in Immunology
BackgroundProtein-polysaccharide conjugate vaccines rely on the induction of T-cell-dependent responses that support germinal center (GC) reactions to potentiate the expansion of antigen-specific memory B-cell (MBC) populations and high-avidity antibody ...
Sonia Budroni, Elisa Faenzi, Simona Tavarini, Chiara Sammicheli, Francesca Buricchi, Gianfranco Volpini, Erica Borgogni, Fabiana Spensieri, Evita Balducci, Bruno Galletti, Maria Rosaria Romano, Ugo D’Oro, Oretta Finco, Monia Bardelli   +13 more
doaj   +2 more sources

Modular assembly and immunological evaluation of a promising bioconjugate nanovaccine against Klebsiella pneumoniae O2 serotype [PDF]

npj Vaccines
The antimicrobial-resistant (AMR) Klebsiella pneumoniae (Kp) poses an enormous threat to human health, with O2 serotypes accounting for up to 35–59% of infections. Although the O-polysaccharide (OPS) of the Kp O2 serotype can be used as an antigen target
Peng Sun, Chao Pan, Huifang Xu, Bo Liu, Jingqin Ye, Kangfeng Wang, Yan Zhang, Ting Li, Li Zhu, Yating Wang, Hengliang Wang, Jun Wu   +11 more
doaj   +2 more sources

Low Seroconversion after One Dose of AS03-Adjuvanted H1N1 Pandemic Influenza Vaccine in Solid-Organ Transplant Recipients [PDF]

Canadian Journal of Infectious Diseases and Medical Microbiology, 2013
BACKGROUND: Immunocompromised individuals are more susceptible to complications produced by influenza infection. As a result, solid-organ transplant (SOT) recipients were targeted as a priority group to receive AS03-adjuvanted H1N1 influenza vaccine ...
Mariangela R Resende, Shahid Husain, Jonathan Gubbay, Lianne Singer, Edward Cole, Eberhard L Renner, Coleman Rotstein   +6 more
doaj   +3 more sources

Differential Regulation of DC Function, Adaptive Immunity, and MyD88 Dependence by Two Squalene Emulsion-Based Vaccine Adjuvants [PDF]

Vaccines
MF59 and AS03 are squalene emulsion-based vaccine adjuvants with similar compositions and droplet sizes. Despite their broad use in licensed influenza vaccines, few studies compared their adjuvant effects and action mechanisms side by side.
Jayachandra Reddy Nakkala, Yibo Li, Labone Akter, Xinliang Kang, Xinyuan Chen   +4 more
doaj   +2 more sources

Antigenic differences between AS03 adjuvanted influenza A (H1N1) pandemic vaccines: implications for pandemrix-associated narcolepsy risk.

PLoS ONE, 2014
BackgroundNarcolepsy results from immune-mediated destruction of hypocretin secreting neurons in hypothalamus, however the triggers and disease mechanisms are poorly understood.
Outi Vaarala, Arja Vuorela, Markku Partinen, Marc Baumann, Tobias L Freitag, Seppo Meri, Päivi Saavalainen, Matti Jauhiainen, Rabah Soliymani, Turkka Kirjavainen, Päivi Olsen, Outi Saarenpää-Heikkilä, Juha Rouvinen, Merja Roivainen, Hanna Nohynek, Jukka Jokinen, Ilkka Julkunen, Terhi Kilpi   +17 more
doaj   +6 more sources

Designer Solid Self-Emulsifying Nanovaccines Enable Dual Modulation of Dendritic Cells and T Cells for Potent Antitumor Immunity. [PDF]

Adv Sci (Weinh)
A solid self‐emulsifying (SSE) platform is loaded with peptide antigens and CpG to form the SSE vaccine. An ApoE‐enriched corona promotes dendritic cell internalization, enabling antigen presentation and T cell activation. Squalene from the SSE also sensitizes T cells by promoting lipid raft formation.
Shen X, Fan S, He J, Luo L, Li J, Wu C, Yang K, Xia X, Kuai R.   +8 more
europepmc   +2 more sources

Narcolepsy, autoimmunity, and influenza A H1N1 vaccination [PDF]

Encephalitis, 2021
Narcolepsy is a rare neurological disorder characterized by excessive daytime sleepiness (EDS) with or without cataplexy. A main pathophysiology of narcolepsy is hypocretin deficiency in the central nervous system resulting from a selective loss of ...
Jun-Sang Sunwoo
doaj   +1 more source

Safety of AS03-adjuvanted influenza vaccines: A review of the evidence.

Vaccine, 2019
Clinical and post-licensure data have demonstrated that AS03-adjuvanted inactivated split virion vaccines, many with reduced antigen content, are effective against influenza infection. The objective of this review is to provide a comprehensive assessment of the safety of trivalent seasonal, monovalent pre-pandemic and pandemic AS03-adjuvanted influenza
C. Cohet, R. G. van der Most, V. Bauchau, R. Bekkat-Berkani, T. Mark Doherty, A. Schuind, F. Tavares Da Silva, R. Rappuoli, N. Garçon, B. Innis   +9 more
semanticscholar   +3 more sources

Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses: A Phase I Randomized Controlled Trial. [PDF]

PLoS ONE, 2017
BACKGROUNDVaccine development for influenza A/H5N1 is an important public health priority, but H5N1 vaccines are less immunogenic than seasonal influenza vaccines. Adjuvant System 03 (AS03) markedly enhances immune responses to H5N1 vaccine antigens, but
Leigh M Howard, Kristen L Hoek, Johannes B Goll, Parimal Samir, Allison Galassie, Tara M Allos, Xinnan Niu, Laura E Gordy, C Buddy Creech, Nripesh Prasad, Travis L Jensen, Heather Hill, Shawn E Levy, Sebastian Joyce, Andrew J Link, Kathryn M Edwards   +15 more
doaj   +1 more source

A note on multiplicative automatic sequences, II [PDF]

, 2019
We prove that any $q$-automatic multiplicative function $f:\mathbb{N}\to\mathbb{C}$ either essentially coincides with a Dirichlet character, or vanishes on all sufficiently large primes. This confirms a strong form of a conjecture of J. Bell, N.
Klurman, Oleksiy, Kurlberg, Pär
core   +10 more sources