Results 31 to 40 of about 5,708 (209)

Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters

Communications Medicine, 2023
Background Since the beginning of the COVID-19 pandemic, several variants of concern (VOC) have emerged for which there is evidence of an increase in transmissibility, more severe disease, and/or reduced vaccine effectiveness.
Catherine Berry, Vincent Pavot, Natalie G. Anosova, Michael Kishko, Lu Li, Tim Tibbitts, Alice Raillard, Sylviane Gautheron, Sheila Cummings, Dinesh S. Bangari, Swagata Kar, Caroline Atyeo, Yixiang Deng, Galit Alter, Cindy Gutzeit, Marguerite Koutsoukos, Roman M. Chicz, Valerie Lecouturier   +17 more
doaj   +1 more source

Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity

Vaccines, 2021
Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies against highly variable globular head of ...
Zhuofan Li, Yiwen Zhao, Yibo Li, Xinyuan Chen   +3 more
doaj   +1 more source

Comparison of different adjuvants for immune efficacy of recombinant PKF protein of Acinetobacter baumannii

陆军军医大学学报, 2023
Objective To compare the immune effects of recombinant PKF protein of Acinetobacter baumannii with different immune modes and different adjuvants. Methods After recombinant PKF protein was obtained by plasmid expression and purification, the protein was ...
ZHANG Shanshan, ZHANG Shanshan, LI Guocheng, FENG Rang, XUE Ruoyi   +4 more
doaj   +1 more source

Proteomics show antigen presentation processes in human immune cells after AS03‐H5N1 vaccination [PDF]

PROTEOMICS, 2017
Adjuvants enhance immunity elicited by vaccines through mechanisms that are poorly understood. Using a systems biology approach, we investigated temporal protein expression changes in five primary human immune cell populations: neutrophils, monocytes, natural killer cells, T cells, and B cells after administration of either an Adjuvant System 03 ...
Allison C, Galassie, Johannes B, Goll, Parimal, Samir, Travis L, Jensen, Kristen L, Hoek, Leigh M, Howard, Tara M, Allos, Xinnan, Niu, Laura E, Gordy, C Buddy, Creech, Heather, Hill, Sebastian, Joyce, Kathryn M, Edwards, Andrew J, Link   +13 more
openaire   +2 more sources

Systems serology-based comparison of antibody effector functions induced by adjuvanted vaccines to guide vaccine design

npj Vaccines, 2023
The mechanisms by which antibodies confer protection vary across vaccines, ranging from simple neutralization to functions requiring innate immune recruitment via Fc-dependent mechanisms.
Carolin Loos, Margherita Coccia, Arnaud M. Didierlaurent, Ahmed Essaghir, Jonathan K. Fallon, Douglas Lauffenburger, Corinne Luedemann, Ashlin Michell, Robbert van der Most, Alex Lee Zhu, Galit Alter, Wivine Burny   +11 more
doaj   +1 more source

A Self-Emulsified Adjuvant System Containing the Immune Potentiator Alpha Tocopherol Induces Higher Neutralizing Antibody Responses than a Squalene-Only Emulsion When Evaluated with a Recombinant Cytomegalovirus (CMV) Pentamer Antigen in Mice

Pharmaceutics, 2023
The development of new vaccine adjuvants represents a key approach to improvingi the immune responses to recombinant vaccine antigens. Emulsion adjuvants, such as AS03 and MF59, in combination with influenza vaccines, have allowed antigen dose sparing ...
Rushit N. Lodaya, Amey P. Kanitkar, Asma Ashraf, Douty Bamba, Mansoor M. Amiji, Derek T. O’Hagan   +5 more
doaj   +1 more source

The primitive spectrum of basic classical Lie superalgebras [PDF]

, 2016
We prove Conjecture 5.7 in [arXiv:1409.2532], describing all inclusions between primitive ideals for the general linear superalgebra in terms of the Ext1-quiver of simple highest weight modules.
Coulembier, Kevin
core   +3 more sources

Characterization of potential biomarkers of reactogenicity of licensed antiviral vaccines: randomized controlled clinical trials conducted by the BIOVACSAFE consortium [PDF]

, 2019
Funding text The authors are grateful for the vital contributions of the participating study volunteers, clinicians, nurses, and laboratory technicians at the Surrey study site.
Bodinham, C., Bottazzi, B., DelGiudice, G., Denoel, P., Greenwood, A., Jonsdottir, I., Kaufmann, S., Kester, K., Leroux-Roels, G., Lewis, D., Linley, C., Maertzdorf, J., Mantovani, A., Mollenkopf, H., Pizzoferro, K., van den Berg, R., Weiner, J.   +16 more
core   +1 more source

Extended antigen sparing potential of AS03-adjuvanted pandemic H1N1 vaccines in children, and immunological equivalence of two formulations of AS03-adjuvanted H1N1 vaccines: results from two randomised trials [PDF]

BMC Infectious Diseases, 2013
Background Pandemic influenza vaccine manufacturing capacity and distribution agility is enhanced through the availability of equivalent antigen-sparing vaccines. We evaluated equivalence in terms of immunogenicity between GlaxoSmithKline Vaccines’ A/California/7/2009 (H1N1)v-like-AS03 vaccines manufactured in Dresden (D-Pan), and Quebec (Q-Pan ...
Launay, Odile, Duval, Xavier, Fitoussi, Serge, Jilg, Wolfgang, Kerdpanich, Angkool, Montellano, May, Schwarz, Tino F., Watanveerade, Veerachai, Wenzel, Jürgen J., Zalcman, Gerard, Bambure, Vinod, Li, Ping, Caplanusi, Adrian, Madan, Anuradha, Gillard, Paul, Vaughn, David W.   +15 more
openaire   +5 more sources

Analysis of the dose-sparing effect of adjuvanted Sabin-inactivated poliovirus vaccine (sIPV)

Human Vaccines & Immunotherapeutics, 2018
Sabin-based inactivated poliovirus vaccine(sIPV) is gradually replacing live-attenuated oral polio vaccine(OPV). Sabin-inactivated poliovirus vaccine(sIPV) has played a vital role in reducing economic burden of poliomyelitis and maintaining appropriate ...
Zhuofan Li, Wenting Ding, Qi Guo, Ze Liu, Zhe Zhu, Shaohui Song, Weidong Li, Guoyang Liao   +7 more
doaj   +1 more source