Results 221 to 230 of about 98,201 (305)

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Role of reactive oxygen species in mediating peripheral hypoxic vasodilation and sympathoexcitation at high altitude

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude acclimatisation increases muscle sympathetic nerve activity (MSNA) via activation of the arterial chemoreflex, pulmonary arterial baroreceptors and resetting of the sympathetic vascular baroreflex. However attempting to silence these mechanisms only partially normalises MSNA, implicating other contributory ...
Liam D. Corr, Andrew J. M. Douglas, Elliott J. Jenkins, Lauren E. Maier, Jodie L. Koep, Travis D. Gibbons, Adam Field, James D. Anholm, Katharine Foster, Zoe H. Adams, Lydia L. Simpson, Jonathan P. Moore, Tinna Traustadottir, Christoph Siebenmann, Joshua C. Tremblay, Mike Stembridge   +15 more
wiley   +1 more source

Redox-Dependent Modulation of Cardiac Mitochondrial F₁F_O-ATPase and Respiratory Function by N-Acetylcysteine and Sodium Ascorbate. [PDF]

Biology (Basel)
Cugliari A, Algieri C, Glogowski PA, Trombetti F, Buscaroli S, Fabbri M, Federici E, Nesci S.   +7 more
europepmc   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

An in-vitro study to characterise analytical interference caused by sodium ascorbate with point-of-care measurement of lactate and glucose. [PDF]

Crit Care Resusc
Webber T, Nadkarni A, Asser I, Tenikoff H, Idris M, Finnis ME, Arce-Arango P, Brown N, Christie C, Doherty S, Foster M, Glasby K, Penglis D, Chai Y, Yeo A, Lankadeva YR, Plummer MP.   +16 more
europepmc   +1 more source

Mitochondrial permeability transition in skeletal muscle phenocopies muscle alterations seen in cancer cachexia and other wasting conditions

The Journal of Physiology, EarlyView.
Abstract figure legend Skeletal muscle wasting conditions are characterized by muscle fibre atrophy, mitochondrial respiratory dysfunction, mitochondrial depletion and fragmentation of acetylcholine receptor (AChR) cluster at the neuromuscular junction.
Maya Semel, Cole Lukasiewicz, Sarah Skinner, Mark R. Viggars, Sung Gi Noh, Martin Picard, Abbey‐Gale Mannings, Michael S. Cohen, Dennis W. Wolan, Terence E. Ryan, Russell T. Hepple   +10 more
wiley   +1 more source

Controlled Generation of Dehydroascorbic Acid: A New Mechanistic Framework for High-Dose Vitamin C Anticancer Therapy. [PDF]

Cells
Peskin AV.
europepmc   +1 more source

Developmental mechanisms contributing to non‐linear firing dynamics in spinal motoneurons of the postnatal mouse

The Journal of Physiology, EarlyView.
Abstract figure legend. In this study, we describe how persistent inward currents (PICs) and nonlinear firing dynamics mature in slow‐type (green) and fast‐type (purple) motoneurons (MNs) during the second and third postnatal weeks of development in mice.
Simon A. Sharples, Gareth B. Miles
wiley   +1 more source

Antioxidant strategies of four native tree species across seasons in urban and peri-urban Atlantic Forest remnants. [PDF]

Environ Monit Assess
da Costa BRB, Anselmo-Moreira F, Corrêa ACP, Dos Santos Lopes A, de Araújo HH, Soares GDD, Mendes JD, Fornaro A, Borbon A, de Souza SR, da Silva LC, Furlan CM.   +11 more
europepmc   +1 more source