Results 241 to 250 of about 95,783 (301)
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Anaerobic reaction of ascorbate oxidase with ascorbate
Archives of Biochemistry and Biophysics, 1978Abstract Ascorbate oxidase is fully reduced by 4 mol of ascorbate in the absence of air, as monitored by optical and electron paramagnetic resonance spectra. At less than stoichiometric ascorbate concentration there is a slow equilibration between the 605-and 330-nm absorption bands: The 605-nm chromophore is first reduced, then its color reappears ...
L, Avigliano +4 more
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Crystal structure of the ascorbate peroxidase–ascorbate complex
Nature Structural & Molecular Biology, 2003Heme peroxidases catalyze the H2O2-dependent oxidation of a variety of substrates, most of which are organic. Mechanistically, these enzymes are well characterized: they share a common catalytic cycle that involves formation of a two-electron, oxidized Compound I intermediate followed by two single-electron reduction steps by substrate.
Sharp, K.H. +3 more
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Ascorbate Sulfate: A Urinary Metabolite of Ascorbic Acid in Man
Science, 1971Ascorbate-3-sulfate is a significant metabolite of ascorbic acid excreted in human urine. The characteristics of this compound were determined in experiments in which labeling with carbon-14 and tritium was used coupled with cochromatography with synthetic ascorbate-3-sulfate (both labeled and not labeled with sulfur-35) in a variety of solvent and ...
E M, Baker +4 more
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The regulation of ascorbate biosynthesis
Current Opinion in Plant Biology, 2016We review the regulation of ascorbate (vitamin C) biosynthesis, focusing on the l-galactose pathway. We discuss the regulation of ascorbate biosynthesis at the level of gene transcription (both repression and enhancement) and translation (feedback inhibition of translation by ascorbate concentration) and discuss the eight proteins that have been ...
Sean Bulley, William Laing
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Bioactivation of Nitroglycerin by Ascorbate
Molecular Pharmacology, 2007Bioactivation of nitroglycerin (GTN) into an activator of soluble guanylate cyclase (sGC) is essential for the vasorelaxant effect of the drug. Besides several enzymes that catalyze GTN bioactivation, the reaction with cysteine is the sole nonenzymatic mechanism known so far. Here we show that a reaction with ascorbate results in GTN bioactivation.
Alexander, Kollau +6 more
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Journal of Dental Research, 1986
This study sought to determine whether the lingual ascorbic acid test (LAAT) and measurement of salivary ascorbate refXect plasma and leukocyte ascorbate levels during controlled periods of ascorbic acid depletion and supplementation. Eleven healthy non-smoking men, aged 19-28 years, ate a diet that was repeated every seven days and ...
P J, Leggott +4 more
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This study sought to determine whether the lingual ascorbic acid test (LAAT) and measurement of salivary ascorbate refXect plasma and leukocyte ascorbate levels during controlled periods of ascorbic acid depletion and supplementation. Eleven healthy non-smoking men, aged 19-28 years, ate a diet that was repeated every seven days and ...
P J, Leggott +4 more
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Ascorbic Acid and Hypertriglyceridemia
Annals of Internal Medicine, 1980Excerpt To the editor: Although increased blood lipid levels have been associated with lowered intracellular and extracellular ascorbic acid levels (1, 2), few or no data exist on treatment of hype...
K L, Geoly, L H, Diamond
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Biochemical and Biophysical Research Communications, 2010
Ascorbic acid (AA) is a common culture medium and dietary supplement. While AA is most commonly known for its antioxidant properties, it is also known to function as a pro-oxidant under select conditions. However, the complexity and often unknown composition of biological culture systems makes prediction of AA behaviour in supplemented cultures ...
Osiecki, Michael +4 more
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Ascorbic acid (AA) is a common culture medium and dietary supplement. While AA is most commonly known for its antioxidant properties, it is also known to function as a pro-oxidant under select conditions. However, the complexity and often unknown composition of biological culture systems makes prediction of AA behaviour in supplemented cultures ...
Osiecki, Michael +4 more
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Ascorbate compartmentalization in the CNS
Neurotoxicity Research, 1999Ascorbic acid, found physiologically as the ascorbate anion, is an abundant water-soluble antioxidant. It is concentrated in the intracellular compartment of all tissues in the body. The CNS has particularly high levels of ascorbate. Recent data from this laboratory indicate that ascorbate is distinctly compartmentalized between neurons and glia, with ...
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Ascorbate status and xerostomia
Medical Hypotheses, 1992Xerostomia, the subjective feeling of dry mouth, affects millions of people particularly the elderly. It is invariably associated with hypofunction of the salivary glands. The amount, rate of secretion, and composition of saliva are regulated by both sympathetic and parasympathetic receptor systems whose stimulation transmits signals through ...
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