Results 41 to 50 of about 3,671 (210)

Early clinical response associates with long-term outcomes with ixekizumab in radiographic axial spondyloarthritis

RMD Open
Background The Assessment of SpondyloArthritis international Society-European Alliance of Associations for Rheumatology recommendations for axial spondyloarthritis (axSpA) management include patient assessment for biological disease-modifying ...
Sofia Ramiro, James Cheng-Chung Wei, Louis Bessette, Soyi Liu-Leage, Cédric Lukas, Rebecca Bolce, Pendleton Wickersham, Tommaso Panni, Boris Janos   +8 more
doaj   +1 more source

Disease activity guided stepwise tapering or discontinuation of rhTNFR:Fc, an etanercept biosimilar, in patients with ankylosing spondylitis: a prospective, randomized, open-label, multicentric study

Therapeutic Advances in Musculoskeletal Disease, 2020
Background: The aim of this study was to evaluate disease-activity-guided stepwise tapering or discontinuation of rhTNFR:Fc, an etanercept biosimilar, in patients with ankylosing spondylitis (AS) in a prospective, randomized, open-label, multicentric ...
Ting Zhang, Jianing Zhu, Dongyi He, Xiaowei Chen, Hongzhi Wang, Ying Zhang, Qin Xue, Weili Liu, Guangbo Xiang, Yasong Li, Zhongming Yu, Huaxiang Wu   +11 more
doaj   +1 more source

Does gender influence outcome measures similarly in patients with spondyloarthritis? Results from the ASAS-perSpA study

RMD Open, 2022
Objectives To investigate the influence of gender on disease outcomes in patients with spondyloarthritis (SpA), including across SpA subtypes.Methods Data from 4185 patients of 23 countries with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or ...
Sofia Ramiro, Maxime Dougados, Anna Molto, Clementina López-Medina, Victoria Navarro-Compán, Diego Benavent, Dafne Capelusnik   +6 more
doaj   +1 more source

Determinants of Difficult‐to‐Manage and Treatment‐Refractory Axial Spondyloarthritis: A Cross‐Sectional Analysis Within a Longitudinal Cohort

Arthritis &Rheumatology, EarlyView.
Objective The purpose of this study was to estimate the prevalence of difficult‐to‐manage (D2M) and treatment‐refractory (TR) axial spondyloarthritis (axSpA) and to identify factors associated with D2M and TR disease in a longitudinal cohort. Methods We performed a cross‐sectional analysis on data from the Schroeder Arthritis Institute Spondylitis ...
Patricia Remalante‐Rayco, Laura Passalent, Tina Chim, Hannah Vijayan, Manal Alnasser, Zeynep Baskurt, Robert D. Inman, Nigil Haroon, Denis Poddubnyy   +8 more
wiley   +1 more source

Comparison of ASDAS and BASDAI as a measure of disease activity in axial psoriatic arthritis

, 2015
The aim of this study was to compare the discriminative ability of Ankylosing Spondylitis Disease Activity Score (ASDAS) with Bath Ankylosing Spondylitis Activity Disease Activity Index (BASDAI) and other clinical disease activity parameters in patients ...
Kilic, Erkan, Ozgocmen, Salih, Nas, Kemal, ÇAPKIN, ERHAN, KARKUCAK, MURAT, Cevik, Remzi, Kilic, Gamze, Dagli, Abdullah Zubeyir   +7 more
core   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Correlation between PCT and ASDAS, CRP, ESR and WBC.

, 2015
Correlation of the serum levels of PCT with ASDAS, CRP, ESR and WBC was evaluated by Spearman correlation test in AS patients (n = 41). PCT was significantly positively correlated with CRP (P = 0.001).
Wen Liu (39804), Yan Huang (46805), Keshav Raj Sigdel (771327), Lihua Duan (304571), Jie Chen (5892), Yan Lin Zhang (771329), Guixiu Shi (771330), Qun Su (771328), Ying Wang (11406)   +8 more
core   +1 more source

Gender difference in ASAS HI among patients with ankylosing spondylitis.

PLoS ONE, 2020
ObjectiveTo assess the associations of the Assessment of Spondyloarthritis International Society Health Index (ASAS HI) with gender and other factors in patients with ankylosing spondylitis (AS).MethodsFrom November 2017 to October 2018, we measured the ...
Hsin-Hua Chen, Yi-Ming Chen, Kuo-Lung Lai, Tsu-Yi Hsieh, Wei-Ting Hung, Ching-Tsai Lin, Chih-Wei Tseng, Kuo-Tung Tang, Yin-Yi Chou, Yi-Da Wu, Chin-Yin Huang, Chia-Wei Hsieh, Wen-Nan Huang, Yi-Hsing Chen   +13 more
doaj   +1 more source

Impact of Dual Interleukin‐17A and Interleukin‐17F Inhibition with Bimekizumab on Inflammatory and Structural Lesions in Axial Spondyloarthritis: MRI and Radiographic Outcomes from the Phase 3 BE MOBILE 1 and 2 Studies and their Open‐Label Extension

Arthritis &Rheumatology, Accepted Article.
Objectives To evaluate the impact of bimekizumab, a dual IL‐17A and IL‐17F inhibitor, on sacroiliac joint (SIJ) and spine inflammation/structural damage in axSpA using MRIs/radiographs from the phase 3 studies BE MOBILE 1 (nr‐axSpA) and 2 (r‐axSpA) and their open‐label extension (OLE).
Walter P. Maksymowych, Sofia Ramiro, Denis Poddubnyy, Xenofon Baraliakos, Robert G.W. Lambert, Ute Massow, Tom Vaux, Chetan Prajapati, Alexander Marten, Natasha de Peyrecave, Mikkel Østergaard   +10 more
wiley   +1 more source

Early diagnosis of axial spondyloarthritis is associated with less long‐term spinal structural damage: a longitudinal analysis of the Swiss Clinical Quality Management in rheumatic diseases registry

Arthritis &Rheumatology, Accepted Article.
Objectives The Assessment of SpondyloArthritis international Society recently defined early axial spondyloarthritis (axSpA) as a duration ≤2 years of axial symptoms. Previous studies have shown no significant difference in short‐term outcomes between early and established axSpA patients treated with biologic/targeted synthetic disease‐modifying anti ...
Annik Steimer, Jonas Brändli, Mauro Bachmann, Andrea Götschi, Claudia L. Rodrigues, Michael J. Nissen, Burkhard Möller, Kristina Bürki, Martin Wendiggensen, Simon Grosswiler, Michael Andor, Diana Dan, Frauke Förger, Sabine Adler, Diego Kyburz, Oliver Distler, Raphael Micheroli, Sofia Ramiro, Adrian Ciurea   +18 more
wiley   +1 more source