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Role of LONP1 in human diseases: molecular mechanisms and therapeutic potential. [PDF]

Cell Mol Biol Lett
Li M, Wang A, Tang C, Qiao Y, Zhang W, Wu Y.   +5 more
europepmc   +1 more source

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Redistribution of ASIC1a channels triggered by IL-6: Potential role of ASIC1a in neuroinflammation

Biochimica Et Biophysica Acta - Molecular Basis of Disease
Cytokines, particularly IL-6, play a crucial role in modulating immune responses in the central nervous system (CNS). Elevated IL-6 levels have been observed in neuroinflammatory conditions, as well as in the sera and brains of patients with neurodegenerative diseases such as Parkinson's, Huntington's, Multiple Sclerosis, and Alzheimer's. Additionally,
Rodolfo G Gatto, Osvaldo D Uchitel, Carina Weissmann   +2 more
exaly   +3 more sources

Role of ASIC1a in Normal and Pathological Synaptic Plasticity

, 2020
Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are broadly distributed in the mammalian nervous system where they play important roles in a variety of physiological processes, including neurotransmission and memory-related behaviors.
Mango, Dalila, Nisticò, Robert
openaire   +5 more sources

ASIC1a Promotes Acid-Induced Autophagy in Rat Articular Chondrocytes through the AMPK/FoxO3a Pathway

International Journal of Molecular Sciences, 2017
Acid-sensing ion channel 1a (ASIC1a) is a member of the extracellular H+-activated cation channels family. Our previous studies suggested that ASIC1a contributed to acid-induced rat articular chondrocytes autophagy.
Yong Chen, Renpeng Zhou, Zhisen Wang
exaly   +2 more sources

Potentiation and Block of ASIC1a by Memantine

Cellular and Molecular Neurobiology, 2017
Acid-sensing ion channels (ASICs) are modulated by various classes of ligands, including the recently described hydrophobic monoamines, which inhibit and potentiate ASICs in a subunit-specific manner. In particular, memantine inhibits ASIC1a and potentiates ASIC2a homomers.
Vasiliy Y, Shteinikov, Tatiana B, Tikhonova, Vyacheslav S, Korkosh, Denis B, Tikhonov   +3 more
openaire   +2 more sources

Kaempferol attenuates carbon tetrachloride (CCl4)-induced hepatic fibrosis by promoting ASIC1a degradation and suppression of the ASIC1a-mediated ERS

Phytomedicine, 2023
Kaempferol is a flavonoid derived from the herb, Kaempferia galanga L., in addition to exhibiting a wide range of pharmacological properties, kaempferol is also an anti-inflammatory, anti-lipid metabolizing, and anti-oxidative stress agent. The underlying molecular mechanisms of its effects on vascular endothelial growth factor (VEGF) secretion and ...
Rui Cao, Chun Cao, Xiaojie Hu, Kang Du, Jingrong Zhang, Mengxue Li, Bowen Li, Huimin Lin, Anqi Zhang, Yangyang Li, Li Wu, Yan Huang   +11 more
openaire   +2 more sources

Fluorescence-Based Automated Screening Assay for the Study of the pH-Sensitive Channel ASIC1a

SLAS Discovery, 2016
Acid-sensing ion channel 1a (ASIC1a) is involved in several pathologies, including neurodegenerative and neuroinflammatory disorders, stroke, epilepsy, and inflammatory pain.
Davide Mazza, Lia Forti, Luca Muzio
exaly   +3 more sources

Determinants of action of hydrophobic amines on ASIC1a and ASIC2a

European Journal of Pharmacology, 2016
Acid-sensing ion channels (ASICs) are involved in numerous physiological and pathological processes in the central nervous system. Development of pharmacological tools capable to inhibit or potentiate these channels is important for our knowledge about roles of ASICs in the neuronal network and can be promising for treatment of some disorders. Recently
Elina I, Nagaeva, Natalia N, Potapieva, Maxim V, Nikolaev, Valery E, Gmiro, Lev G, Magazanik, Denis B, Tikhonov   +5 more
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Photomodulation of the ASIC1a acidic pocket destabilizes the open state

Protein Science, 2023
AbstractAcid‐sensing ion channels (ASICs) are important players in detecting extracellular acidification throughout the brain and body. ASICs have large extracellular domains containing two regions replete with acidic residues: the acidic pocket, and the palm domain.
Matthew L. Rook, Tyler W. McCullock, Tyler Couch, John D. Lueck, David M. MacLean   +4 more
openaire   +2 more sources

ASIC1a polymorphism is associated with temporal lobe epilepsy

Epilepsy Research, 2011
Recent in vitro and in vivo data show that acid-sensing ion channel 1a (ASIC1a) activation enhances neuronal excitability in the hippocampus and neocortex, indicating that ASIC1a might play a role in the generation and maintenance of epileptic seizures. The aim of this study was to investigate association of the ASIC1a gene with temporal lobe epilepsy (
Rui-Juan, Lv, Jin-Sheng, He, Yuan-Hui, Fu, Ya-Qing, Zhang, Xiao-Qiu, Shao, Li-Wen, Wu, Qiang, Lu, Li-Ri, Jin, Hui, Liu   +8 more
openaire   +2 more sources