Results 171 to 180 of about 2,309 (187)

Upregulation of ASIC1a channels in an in vitro model of Fabry disease

Neurochemistry International, 2020
Neuropathic pain is one of the key features of the classical phenotype of Fabry disease (FD). Acid sensing ion channels (ASICs) are H+-gated cation channels, which belong to the epithelial sodium channel/DeGenerin superfamily, sensitive to the diuretic drug Amiloride. Molecular cloning has identified several distinct ASIC subunits.
Libia Catalina Salinas Castellanos, Paula Rozenfeld, Rodolfo Gabriel Gatto, Ricardo Claudio Reisin, Osvaldo Daniel Uchitel, Carina Weissmann   +5 more
openaire   +3 more sources

ASIC1a induces mitochondrial apoptotic responses in acute lung injury

European Journal of Pharmacology, 2022
This study aimed to investigate the promoting effect of acid-sensing ion channel 1a (ASIC1a) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and its mechanisms.In this experiment, the ALI rat model was induced by intratracheal injection of LPS, and the ASIC1a specific blocker psalmotoxin-1 (PcTx-1) was injected into the tail vein before LPS
Yangyang Li, Anqi Zhang, Kuayue Li, Dahai Zhao, Feng Li, Songyan Liao, Yunting Zhang, Yan Huang   +7 more
openaire   +2 more sources

σ-1 Receptor Modulation of Acid-Sensing Ion Channel a (ASIC1a) and ASIC1a-Induced Ca2+ Influx in Rat Cortical Neurons

The Journal of Pharmacology and Experimental Therapeutics, 2008
Acid-sensing ion channels (ASICs) are proton-gated cation channels found in peripheral and central nervous system neurons. The ASIC1a subtype, which has high Ca2+ permeability, is activated by ischemia-induced acidosis and contributes to the neuronal loss that accompanies ischemic stroke.
Yelenis, Herrera, Christopher, Katnik, Jael D, Rodriguez, Aaron A, Hall, Alison, Willing, Keith R, Pennypacker, Javier, Cuevas   +6 more
openaire   +2 more sources

ASIC1a-CMPK2-mediated M1 macrophage polarization exacerbates chondrocyte senescence in osteoarthritis through IL-18

International Immunopharmacology, 2023
Yingjie Zhao, Wei Hu, Yong Chen
exaly  

ASIC1a promotes acidic microenvironment-induced HCC cells migration and invasion by inducing autophagy

European Journal of Pharmacology, 2021
Huan Wang, Jin Zhang, Peng Jiang
exaly  

Protein Kinase C Regulates ASIC1a Protein Expression and Channel Function via NF-kB Signaling Pathway

Molecular Neurobiology, 2020
Ling Zhang, Tian-Dong Leng, Zhi-Gang Xiong   +2 more
exaly  

Intracellular ASIC1a regulates mitochondrial permeability transition-dependent neuronal death

Cell Death and Differentiation, 2013
Wei-Zheng Zeng, Yu Huang, Tang D
exaly  

ASIC1a promotes synovial invasion of rheumatoid arthritis via Ca2+/Rac1 pathway

International Immunopharmacology, 2020
Yubin Feng, Xuewen Qian, Cong Wang
exaly  

ASIC1a

2013
openaire   +1 more source

ASIC1a channels regulate mitochondrial ion signaling and energy homeostasis in neurons

Journal of Neurochemistry, 2020
Qin Hu, Michael X Zhu, Israel Sekler
exaly