The PPIP5K Family Member Asp1 Controls Inorganic Polyphosphate Metabolism in S. pombe [PDF]
Journal of Fungi, 2021 Inorganic polyphosphate (polyP) which is ubiquitously present in both prokaryotic and eukaryotic cells, consists of up to hundreds of orthophosphate residues linked by phosphoanhydride bonds.
Marina Pascual-Ortiz +3 more
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Operating mechanism and molecular dynamics of pheromone-binding protein ASP1 as influenced by pH. [PDF]
PLoS ONE, 2014 Odorant binding protein (OBP) is a vital component of the olfactory sensation system. It performs the specific role of ferrying odorant molecules to odorant receptors.
Lei Han +6 more
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Transporter-Driven Glycerophosphocholine (GPC) Toxicity Is Conserved from Fission Yeast to Budding Yeast: Roles for Inositol Pyrophosphates and Gde1 Regulation in Fission Yeast [PDF]
BiomoleculesGlycerophosphocholine (GPC) and glycerophosphoinositol (GPI) are phospholipid metabolites generated by phospholipase-mediated deacylation. In budding yeast, they enter cells via the Git1 permease; in fission yeast, the homolog is Tgp1.
Victoria Lee Hrach +8 more
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Post-Translational Modifications Distinguish Amyloid-β Isoforms in Cerebral Amyloid Angiopathy and Alzheimer's Disease. [PDF]
J NeurochemCerebral amyloid angiopathy (CAA) is characterized by progressive vascular deposition of fibrillar Aβ. Using Lys‐N digestion and quantitative mass spectrometry, we profiled Aβ isoforms and N‐terminal post‐translational modifications (PTMs) across CAA severities.
Koutarapu S +8 more
europepmc +2 more sources
Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1 [PDF]
mBioInositol pyrophosphates are signaling molecules that regulate cellular phosphate homeostasis in eukaryal taxa. In fission yeast, where the phosphate regulon (comprising phosphate acquisition genes pho1, pho84, and tgp1) is repressed under phosphate ...
Beate Schwer +4 more
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Enzymatization of mouse monoclonal antibodies to the corresponding catalytic antibodies [PDF]
Scientific ReportsCatalytic antibodies possess a dual function that enables both antigen recognition and degradation. However, their time-consuming preparation is a significant drawback.
Emi Hifumi +4 more
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Prodomain Processing of Asp1 (BACE2) Is Autocatalytic [PDF]
Journal of Biological Chemistry, 2001 Generation of the amyloid peptide through proteolytic processing of the amyloid precursor protein by beta- and gamma-secretases is central to the etiology of Alzheimer's disease. The highly elusive beta-secretase was recently identified as a transmembrane aspartic proteinase, Asp2 (BACE).
Hussain I +4 more
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The Asp1 pyrophosphatase from S. pombe hosts a [2Fe-2S]2+ cluster in vivo [PDF]
JBIC Journal of Biological Inorganic Chemistry, 2021 AbstractTheSchizosaccharomyces pombeAsp1 protein is a bifunctional kinase/pyrophosphatase that belongs to the highly conserved eukaryotic diphosphoinositol pentakisphosphate kinase PPIP5K/Vip1 family. The N-terminal Asp1 kinase domain generates specific high-energy inositol pyrophosphate (IPP) molecules, which are hydrolyzed by the C-terminal Asp1 ...
Hannah Rosenbach +7 more
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Des-asp1-angiotensin I: A metabolite of angiotensin I in the perfused feline adrenal [PDF]
European Journal of Pharmacology, 1976 The administration of radioactive angiotensin I to the retrogradely perfused feline adrenal gland caused a brisk discharge of catecholamines. Recovery of the labelled decapeptide and metabolites in the adrenal effluent fluid was complete in 5 min.
J A, Ackerly, T S, Felger, M J, Peach
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The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. [PDF]
PLoS Genetics, 2014 Microtubules (MTs) are pivotal for numerous eukaryotic processes ranging from cellular morphogenesis, chromosome segregation to intracellular transport. Execution of these tasks requires intricate regulation of MT dynamics.
Jennifer Pöhlmann +11 more
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