Results 51 to 60 of about 2,537 (176)
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Asp1 is required for growth zone selection.
, 2014 (A) The indicated strains were released from stationary phase by streaking cells on solid YE5S at 25°C and analyzing the cell shape microscopically. Wild-type strain, n = 16; asp1H397A, n = 19; asp1D333A strain, n = 15. (B) Photomicrograph of a wild-type
Reinhard Fischer (182192) +11 more
core +1 more source
Interphase MT dynamics in asp1 variant strains.
, 2014 Parameters of MT dynamics were measured for the indicated strains expressing nmt81::gfp-atb2+. Cells were grown in non-selective minimal medium. n, number of MTs measured; asterisks denote significance between wild-type and mutant; ↓ or ↑, parameter is ...
Reinhard Fischer (182192) +11 more
core +1 more source
Frontiers in Microbiology, 2018 Biofilm formation is crucial for bacterial community development and host colonization by Streptococcus salivarius, a pioneer colonizer and commensal bacterium of the human gastrointestinal tract.
Benoit Couvigny +11 more
doaj +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Senescent cancer cells exhibit a secretory phenotype, known as SASP, capable of inducing paracrine senescence. However, the main factors within the SASP triggering this process are unknown. Here, we demonstrate that EVs within the SASP are necessary and sufficient to induce paracrine senescence.
Valentin Estevez‐Souto +21 more
wiley +1 more source
Asp1 MT regulation functions independently of Mal3.
, 2014 (A) Serial dilution patch test (104–101 cells) of the indicated strains grown for 5 days at 25°C on YE5S without (−) or with (+) TBZ. (B) Serial dilution patch test (104–101 cells) of the indicated strains grown for 5 days at 25°C on YE5S without (−) or ...
Reinhard Fischer (182192) +11 more
core +1 more source
Alzheimer's Aβ peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on Cu2+ coordination. [PDF]
PLoS ONE, 2010 BACKGROUND: The amyloid-β (Aβ) peptide is the primary component of the extracellular senile plaques characteristic of Alzheimer's disease (AD).
Simon C Drew +2 more
doaj +1 more source
Inositol pyrophosphate kinases in health and disease
FEBS Letters, Volume 600, Issue 17, Page 2379-2396, September 2026.In mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Changchang Xing +6 more
wiley +1 more source
Model for the regulation of Asp1 kinase function by the C-terminal phosphatase domain.
, 2014 (A) In vitro IP7 output of wild-type Asp1 (top), Asp1H397A (middle) and Asp1 plus Asp1365-920 (phosphatase domain only). ++++ - +, high to low IP7 output. (B) Two possible modes of action are shown.
Reinhard Fischer (182192) +11 more
core +1 more source
Asp1 Bifunctional Activity Modulates Spindle Function via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces pombe [PDF]
, 2018 The generation of two daughter cells with the same genetic information requires error-free chromosome segregation during mitosis. Chromosome transmission fidelity is dependent on spindle structure/function, which requires Asp1 in the fission yeast ...
Pascual-Ortiz, M +7 more
core +1 more source