Results 71 to 80 of about 2,537 (176)

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Three Decades of China's Bt Cotton: Achievements and Insights

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4393-4414, June 2026.
ABSTRACT Cotton is a vital natural fibre crop with significant economic value worldwide. In response to the threat of cotton bollworm (Helicoverpa armigera), the China government initiated a research project in 1992 to develop transgenic Bacillus thuringiensis (Bt) cotton.
Zhigang Meng, Xiufeng Han, Guangqin Yang, Yuan Wang, Yi Zhou, Qi Zhou, Yanyan Li, Tao Zhou, Sandui Guo, Shuangxia Jin, Chengzhen Liang   +10 more
wiley   +1 more source

DES-ASP1-Angiotensin II: Possible Role in Mediating Responses of the Renin-Angiotensin System

Experimental Biology and Medicine, 1975
In dexamethasone-treated dogs, both antiogensin II and its heptapeptide fragment (des-asp1-angiotensin II) stimulated the secretion of the adrenal steroids aldosterone, corticosterone, and cortisol. Further, there was no statistically significant difference in the steroidogenic potency of the two peptides.
T E, Lohmeier, J O, Davis, R H, Freeman
openaire   +2 more sources

3RAD‐Guided SNP Discovery for Species Identification and Conservation of the Medicinal Southern African Tree Genus Greyia Hook. & Harv.

Ecology and Evolution, Volume 16, Issue 5, May 2026.
A two‐phase SNP discovery and assay‐development strategy was used to resolve species boundaries within the tree genus Greyia, as overlapping phenotypes and distributions limit accurate identification. From 47,726 genome‐wide SNPs generated by 3RAD sequencing, a diagnostic 23‐SNP Type panel was developed and validated, successfully distinguishing G ...
Iné Botha, Simo N. Maduna, Snorre B. Hagen, Namrita Lall, Dave K. Berger   +4 more
wiley   +1 more source

Natural Negative Feedback Loops Confer Indica‐Japonica Differentiation for Grain Size Homeostasis in Rice

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li, Meng‐en Wu, Ziqi Qiao, Junkui Huang, Juncheng Zhang, Yang Ding, Junqing Zhu, Jingyue Xu, Yuxin Huang, Wei Li, Xiaomin Su, Yue Ding, Jianwei Zhang, Yibo Li   +13 more
wiley   +1 more source

Genome‐wide exploration of bacterial leaf blight resistance and fine mapping of major resistance gene (Bb13) in upland cotton (Gossypium hirsutum L.)

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Cotton bacterial blight (CBB), caused by Xanthomonas citri subsp. malvacearum (Xcm), continues to pose a significant threat to upland cotton (Gossypium spp.) production across the US Cotton Belt. To elucidate the genetic basis of resistance to race 18 of CBB and identify potential novel resistance sources, we conducted genome‐wide association ...
Spoorti S. Gandhadmath, Fred M. Bourland, S. Anjan Gowda, Navin Shrestha, Don C. Jones, Kaitlyn Bissonnette, Vasu Kuraparthy   +6 more
wiley   +1 more source

Arabidopsis small ubiquitin‐related modifier protease ASP1 positively regulates abscisic acid signaling during early seedling development

, 2018
The small ubiquitin-related modifier (SUMO) modification plays an important role in the regulation of abscisic acid (ABA) signaling, but the function of the SUMO protease, in ABA signaling, remains largely unknown.
Wang, Qiongli, Qu, Gao-Ping, Yan Yan, Qiongli Wang, Jigang Li, Xiangxiong Kong, Jin, Jing Bo, Jing Bo Jin, Yan, Yan, Li, Jigang, Gao‐Ping Qu, Kong, Xiangxiong   +11 more
core   +1 more source

Characterizing the Lanthanide‐Binding Tag Grafted at Calmodulin Site 1: Affinity, Selectivity, and Coordination Properties

European Journal of Inorganic Chemistry, Volume 29, Issue 3, January 21, 2026.
Lanthanide affinity and selectivity in proteins remain poorly understood. Engineering calmodulin with a lanthanide‐binding tag at Site 1 boosts affinity from nanomolar (isolated LBTs) to picomolar dissociation constants, comparable to lanmodulin but with distinct selectivity.
Catherine Berthomieu, Manon Martin, Jean Aupiais, Tiffanie Barré, Loïc Daronnat, Jérémy Pansier, Nicolas Brémond, David Lemaire, Atul Thawari, Martin Levier, Laurence Berthon, Sandrine Sauge‐Merle   +11 more
wiley   +1 more source

Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides

Neurobiology of Disease, 2015
The neuropathological hallmarks of Alzheimer's disease include extracellular neuritic plaques and neurofibrillary tangles. The neuritic plaques contain β-amyloid peptides (Aβ peptides) as the major proteinaceous constituent and are surrounded by ...
Timo Jan Oberstein, Philipp Spitzer, Hans-Wolfgang Klafki, Philipp Linning, Florian Neff, Hans-Joachim Knölker, Piotr Lewczuk, Jens Wiltfang, Johannes Kornhuber, Juan Manuel Maler   +9 more
doaj   +1 more source

Phase I study of TY-10721 ((Asp1-Ile5) angiotensin II).

Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 1990
Angiotensin-II-Induced Hypertension Chemotherapy is an approach to selective enhancement of drug delivery to tumor tissue for increase of chemotherapeutic effects. TY-10721 (TY) is a newly synthesized compound of human type of angiotensin II ([Asp1-Ile5] angiotensin II) by TOA EIYO Ltd.(Tokyo).Along with and after stopping of the continuous infusion of
SATO, Haruhiko, HOSHI, Masahiko, WAKUI, Akira, SUZUKI, Maroh   +3 more
openaire   +2 more sources