Results 61 to 70 of about 2,024 (149)

Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides

Neurobiology of Disease, 2015
The neuropathological hallmarks of Alzheimer's disease include extracellular neuritic plaques and neurofibrillary tangles. The neuritic plaques contain β-amyloid peptides (Aβ peptides) as the major proteinaceous constituent and are surrounded by ...
Timo Jan Oberstein, Philipp Spitzer, Hans-Wolfgang Klafki, Philipp Linning, Florian Neff, Hans-Joachim Knölker, Piotr Lewczuk, Jens Wiltfang, Johannes Kornhuber, Juan Manuel Maler   +9 more
doaj   +1 more source

Comparison of Ischemia‐Modified Albumin Levels in Infertile Men With Mild, Moderate, and Severe Oligozoospermia

Andrologia, Volume 2026, Issue 1, 2026.
Objective The objective of this study is to determine whether IMA (Ischemic Modified Albumin), a new oxidative stress (OS) marker, can be used to predict the degree of oligozoospermia in infertile men. Materials and Methods Oligozoospermic male patients (n = 113) who remained infertile despite regular, unprotected sexual intercourse for more than 12 ...
Miraç Ataman, Ercan Yuvanç, Erdal Yılmaz, Mehmet Emin Ataman, Özcan Erel, Salim Neşelioğlu, Harleen Khatra   +6 more
wiley   +1 more source

DES-ASP1-Angiotensin II: Possible Role in Mediating Responses of the Renin-Angiotensin System

Experimental Biology and Medicine, 1975
In dexamethasone-treated dogs, both antiogensin II and its heptapeptide fragment (des-asp1-angiotensin II) stimulated the secretion of the adrenal steroids aldosterone, corticosterone, and cortisol. Further, there was no statistically significant difference in the steroidogenic potency of the two peptides.
T E, Lohmeier, J O, Davis, R H, Freeman
openaire   +2 more sources

Binding of Hg(I) and Hg(II) Ions to Amyloid‐Beta (Aβ) Peptide Variants Affect their Structure and Aggregation

ChemBioChem, Volume 26, Issue 24, December 11, 2025.
Mercury (Hg) is a possible risk factor for Alzheimer's disease, where neuronal death is related to amyloid brain plaques containing aggregated amyloid‐β (Aβ) peptides. We show that equimolar Hg(I) or Hg(II) ions inhibit normal Aβ aggregation. Hg(II) binds Aβ(1–40) with an apparent binding affinity 28 ± 8 μM.
Elina Berntsson, Andra Noormägi, Kärt Padari, Jüri Jarvet, Astrid Gräslund, Margus Pooga, Peep Palumaa, Sebastian K. T. S. Wärmländer   +7 more
wiley   +1 more source

NUDIX hydrolases target specific inositol pyrophosphates and regulate phosphate homeostasis and bacterial pathogen susceptibility in Arabidopsis

Journal of Integrative Plant Biology, Volume 67, Issue 12, Page 3123-3151, December 2025.
NUDIX‐type hydrolase enzymes of subclade I and II preferentially target the inositol pyrophosphate messengers 4‐ and 3‐InsP7, respectively. Inactivation of subclade II NUDTs disrupts phosphate homeostasis and enhances bacterial resistance, revealing connections between defense and nutrient signaling.
Robin Schneider, Klea Lami, Isabel Prucker, Sara Christina Stolze, Annett Strauß, Julie Marie Schmidt, Simon M. Bartsch, Kevin Langenbach, Esther Lange, Kevin Ritter, David Furkert, Natalie Faiß, Sandeep Kumar, M. Shamim Hasan, Athanasios Makris, Lukas Krusenbaum, Stefanie Wege, Yemisrach Zewdu Belay, Simon Kriescher, Jeremy The, Michael Harings, Florian M. W. Grundler, Martina K. Ried‐Lasi, Heiko Schoof, Philipp Gaugler, Marília Kamleitner, Dorothea Fiedler, Hirofumi Nakagami, Ricardo F. H. Giehl, Thomas Lahaye, Saikat Bhattacharjee, Henning J. Jessen, Verena Gaugler, Gabriel Schaaf   +33 more
wiley   +1 more source

Inositol Pyrophosphate Kinase Asp1 Modulates Chromosome Segregation Fidelity and Spindle Function in Schizosaccharomyces pombe [PDF]

Molecular and Cellular Biology, 2016
Chromosome transmission fidelity during mitosis is of critical importance for the fitness of an organism, as mistakes will lead to aneuploidy, which has a causative role in numerous severe diseases. Proper segregation of chromosomes depends on interdependent processes at the microtubule-kinetochore interface and the spindle assembly checkpoint. Here we
Boris, Topolski, Visnja, Jakopec, Natascha A, Künzel, Ursula, Fleig   +3 more
openaire   +2 more sources

SP3 and DEP1 Orchestrate Panicle Architecture by Jointly Regulating APO2 Expression in Rice

Advanced Science, Volume 12, Issue 44, November 27, 2025.
The transcription factor SP3 enhances inflorescence meristem activity and interacts with the cysteine‐rich domain of DEP1. This interaction alters DEP1's subcellular localization between the plasma membrane and nucleus, and suppresses SP3‐mediated transcriptional activation of APO2.
Yuexin Liu, Niannian Chen, Xiaowei Fan, Xueqing Xia, Yilong Yao, Wen Huang, Jin Sun, Lintao Huang, Lei Wang, Hong Yu, Jiayang Li, Yongzhong Xing   +11 more
wiley   +1 more source

Contribution of Amino Acids in Cereal Grain Products to Precision Feed Formulation for Tambaqui (Colossoma macropomum) Using a Digestibility Approach

Journal of Animal Physiology and Animal Nutrition, Volume 109, Issue 6, Page 1264-1272, November 2025.
ABSTRACT Although cereal grain products have low protein content, they can contribute up to 25% of total protein in low‐trophic level/omnivorous fish diets. Thus, understanding the amino acid contribution of these ingredients becomes crucial for meeting the dietary requirements of omnivorous fish.
Danilo C. Proença, Monaliza F. Sena, Janaína G. Araújo, Guilherme W. Bueno, Igo G. Guimarães   +4 more
wiley   +1 more source

Uncovering yield-related traits loci in Chinese wheat landraces using GWAS

Frontiers in Plant Science
The genetic basis of wheat yield is highly complex, being collectively influenced by key traits such as plant morphology, spike structure, and grain morphology.
Ying Guo, Zhe Zhang, Rui He, Rui Ma, Fangping Yang, Lijun Zhang, Zongbing Zhan, Na Liu, Caixia Lan, Bin Bai   +9 more
doaj   +1 more source

Genetic suppression of precocious transcription termination identifies mutations in essential subunits of the fission yeast cleavage and polyadenylation machinery. [PDF]

RNA
Innokentev A, Sanchez AM, Bednor L, Babor J, Schwer B, Shuman S.   +5 more
europepmc   +1 more source