Results 11 to 20 of about 14,723 (146)

Weight Loss During Obesity Provokes Asparaginase-Associated Liver Steatosis and Endoplasmic Reticulum Stress. [PDF]

FASEB J
Lean mice and DIO mice were fed either a low‐fat maintenance diet (MD) or a high‐fat obesogenic diet (OD) during pegylated asparaginase exposure. OD exacerbated asparaginase‐induced weight loss and modestly increased liver triglycerides and ER stress in lean mice.
Bhavsar CT, Zalma BA, Tomoo K, Zhang Y, Lopez EM, Mirek ET, Dixon JL, Henderson GC, Wek RC, Anthony TG.   +9 more
europepmc   +2 more sources

Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation

Haematologica, 2016
L-asparaginase is an integral component of therapy for acute lymphoblastic leukemia. However, asparaginase-related complications, including the development of hypersensitivity reactions, can limit its use in individual patients.
Inge M. van der Sluis, Lynda M. Vrooman, Rob Pieters, Andre Baruchel, Gabriele Escherich, Nicholas Goulden, Veerle Mondelaers, Jose Sanchez de Toledo, Carmelo Rizzari, Lewis B. Silverman, James A. Whitlock   +10 more
doaj   +1 more source

Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimen

eJHaem, 2023
PEG‐asparaginase is used as a treatment for Philadelphia‐negative acute lymphoblastic leukemia. In pediatric studies, triglycerides (TGs) were affected more by PEG‐asparaginase than by native L‐asparaginase (10.0% vs. 5.5%).
Ibrahim Al Nabhani, Claire Andrews, Jad Sibai, Eshetu Atenafu, Taylor Young, Steven M. Chan, Vikas Gupta, Dawn Maze, Aaron D. Schimmer, Andre C. Schuh, Karen Yee, Hassan Sibai   +11 more
doaj   +1 more source

Prolonged versus standard native E. coli asparaginase therapy in childhood acute lymphoblastic leukemia and non-Hodgkin lymphoma: final results of the EORTC-CLG randomized phase III trial 58951

Haematologica, 2017
Asparaginase is an essential component of combination chemotherapy for childhood acute lymphoblastic leukemia and non-Hodgkin lymphoma. The value of asparaginase was further addressed in a group of non-very high-risk patients by comparing prolonged (long-
Veerle Mondelaers, Stefan Suciu, Barbara De Moerloose, Alina Ferster, Françoise Mazingue, Geneviève Plat, Karima Yakouben, Anne Uyttebroeck, Patrick Lutz, Vitor Costa, Nicolas Sirvent, Emmanuel Plouvier, Martine Munzer, Maryline Poirée, Odile Minckes, Frédéric Millot, Dominique Plantaz, Philip Maes, Claire Hoyoux, Hélène Cavé, Pierre Rohrlich, Yves Bertrand, Yves Benoit   +22 more
doaj   +1 more source

Isolasi Enzim L-Asparaginase dari Rimpang Temulawak (Curcuma xanthorrhiza Roxb.) dan Uji Potensi terhadap Kultur Sel Leukemia Tipe K562

Jurnal Kimia Sains dan Aplikasi, 2010
Enzim L-Asparaginase merupakan enzim yang menghidrolisis L-asparagin menjadi asam L-aspartat dan amonia. L-Asparaginase dapat digunakan untuk mengobati penyakit kanker, yang bekerja dengan cara menghambat sintesis protein sel kanker tanpa merusak sel ...
Oktarina Puspitasari, Wuryanti Wuryanti
doaj   +1 more source

L-asparaginase: New about Well-Known Drug

Педиатрическая фармакология, 2021
The history of asparaginase clinical use is inextricably linked to the improvement of treatment programs for acute lymphoblastic leukaemia (ALL). Asparaginase, obtained from E.
Yuliya S. Korkina, Timur T. Valiev
doaj   +1 more source

Asparaginase Therapy in Pediatric Acute Lymphoblastic Leukemia: A Focus on the Mode of Drug Resistance

Pediatrics and Neonatology, 2015
Asparaginase is one of the most important chemotherapeutic agents against pediatric acute lymphoblastic leukemia (ALL), the most common form of childhood cancer.
Shih-Hsiang Chen
doaj   +1 more source

Asparaginase-Induced Acute Necrotizing Pancreatitis Resulting in Chronic Pancreatitis and Pseudocyst in an Adult with Acute Lymphocytic Leukemia

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2023
L-Asparaginase is one of the main chemotherapy regiments for acute lymphocytic leukemia (ALL) management. Acute pancreatitis is one of the serious side effects of l-asparaginase administration and may lead to interruption of chemotherapy cycle. Long term
Randy Adiwinata, Bradley Jimmy Waleleng, Harlinda Haroen, Linda Rotty, Fandy Gosal, Luciana Rotty, Cecillia Hendratta, Pearla Lasut, Jeanne Winarta, Andrew Waleleng, Michael Tendean   +10 more
doaj   +1 more source

Refolding and purification of recombinant L-asparaginase from inclusion bodies of E. coli in to active tetrameric protein

Frontiers in Microbiology, 2014
A tetrameric protein of therapeutic importance, Escherichia coli L-Asparaginase-II was expressed in Escherichia coli as inclusion bodies. Asparaginase inclusion bodies were solubilized using low concentration of urea and refolded into active tetrameric ...
Arun K Upadhyay, Anupam eSingh, K J Mukherjee, Amulya Kumar Panda   +3 more
doaj   +1 more source

Cloning and Gene Expression of AnsZ Encoding L-Asparaginase Enzyme from Local Bacillus sp.

Microbiology Indonesia, 2014
L-asparaginase is an enzyme that catalyzes the hydrolysis of L-asparagine into L-aspartic acid and ammonia. In medical aspect, L-asparaginase especially those came from E.
RIMA AZARA, IS HELIANTI, JONI KUSNADI, YUNIANTA YUNIANTA   +3 more
doaj   +1 more source