Results 1 to 10 of about 99,734 (259)

Targeting asparagine potentiates anti-PD-L1 immunotherapy in gastric cancer by enhancing CD8+ T cell anti-tumor response [PDF]

Frontiers in Immunology
IntroductionImmunotherapy efficacy in gastric cancer (GC) is often constrained by the tumor microenvironment (TME), which is profoundly influenced by aberrant metabolism. Asparagine, an amino acid critical for neoplastic proliferation, also modulates CD8+
Mingpai Ge, Mingpai Ge, Mingpai Ge, Longfei Wang, Longfei Wang, Bowen Zheng, Bowen Zheng, Lu Zhan, Lu Cui, Han Wang, Enyuan Huang, Yuan Xu, Xusheng Chang, Zhaorui Liu, Jun Xu, Kai Yin, Kai Yin   +16 more
doaj   +2 more sources

Asparagine-related biomarkers and regulatory mechanisms in type 2 diabetes mellitus [PDF]

Frontiers in Molecular Biosciences
BackgroundType 2 diabetes mellitus (T2DM) is a complex metabolic disorder. Emerging evidence suggests asparagine metabolism might play a pivotal role in T2DM, yet the underlying molecular mechanisms remain elusive.
Jiayi Xia, Tao Cai, Peiyin Chen, Lu Gan, Bo Cao, Mingming Kong   +5 more
doaj   +2 more sources

Asparagine: A Metabolite to Be Targeted in Cancers

Metabolites, 2021
Amino acids play central roles in cancer progression beyond their function as building blocks for protein synthesis. Thus, targeting amino acid acquisition and utilization has been proved to be therapeutically beneficial in various pre-clinical models ...
Jie Jiang, Sandeep Batra, Ji Zhang
exaly   +3 more sources

Aspartate Metabolism Facilitates IL-1β Production in Inflammatory Macrophages

Frontiers in Immunology, 2021
Increasing evidence support that cellular amino acid metabolism shapes the fate of immune cells; however, whether aspartate metabolism dictates macrophage function is still enigmatic.
Hao Wang, Xueyue Zheng, Bingnan Liu, Yaoyao Xia, Zhongquan Xin, Baichuan Deng, Liuqin He, Liuqin He, Jinping Deng, Wenkai Ren   +9 more
doaj   +1 more source

Assimilation of Nitrate into Asparagine for Transport in Soybeans

Agronomy, 2023
In this study, the systematic analysis of nitrate assimilation and transport in soybean roots was further improved by analyzing the concentrations of nitrate assimilates, asparagine and glutamine, in soybean roots and the related enzyme activities.
Sha Li, Xiaochen Lyu, Xuelai Wang, Shuhong Zhao, Chunmei Ma, Chao Yan, Zhenping Gong   +6 more
doaj   +1 more source

Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress

Frontiers in Oncology, 2021
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC cells consume large amounts of glutamine to survive, but can adapt to glutamine depletion in the presence of an exogenous asparagine.
Keiichiro Okuda, Atsushi Umemura, Seita Kataoka, Kota Yano, Aya Takahashi, Shinya Okishio, Hiroyoshi Taketani, Yuya Seko, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Hayato Nakagawa, Yu Liu, Yasuhide Mitsumoto, Yoshihiro Kanbara, Toshihide Shima, Takeshi Okanoue, Yoshito Itoh   +17 more
doaj   +1 more source

SLC1A5 provides glutamine and asparagine necessary for bone development in mice

eLife, 2021
Osteoblast differentiation is sequentially characterized by high rates of proliferation followed by increased protein and matrix synthesis, processes that require substantial amino acid acquisition and production.
Deepika Sharma, Yilin Yu, Leyao Shen, Guo-Fang Zhang, Courtney M Karner   +4 more
doaj   +1 more source

Understanding the Relationships between Free Asparagine in Grain and Other Traits to Breed Low-Asparagine Wheat

Plants, 2022
Since the discovery of acrylamide in food, and the identification of free asparagine as the key determinant of acrylamide concentration in wheat products, our understanding of how grain asparagine content is regulated has improved greatly.
Joseph Oddy, Sarah Raffan, Mark D. Wilkinson, J. Stephen Elmore, Nigel G. Halford   +4 more
doaj   +1 more source

Cereal grain with low acrylamide formation potential as a raw material for safer cereal-based food products in Serbia [PDF]

Selekcija i Semenarstvo, 2022
The presence of acrylamide, a mutagen and a Group 2A carcinogen, in food, is a health concern that might raise cancer risk. Acrylamide is mainly formed in the Maillard reaction between free asparagine and reducing sugars, during industrial thermal food ...
Nikolić Valentina, Žilić Slađana, Simić Marijana, Kravić Natalija, Kandić Vesna, Brankov Milan, Vasić Marko   +6 more
doaj   +1 more source

Differential gene expression provides leads to environmentally regulated soybean seed protein content

Frontiers in Plant Science, 2023
Soybean is an important global source of plant-based protein. A persistent trend has been observed over the past two decades that soybeans grown in western Canada have lower seed protein content than soybeans grown in eastern Canada.
Julia C. Hooker, Julia C. Hooker, Myron Smith, Gerardo Zapata, Martin Charette, Doris Luckert, Ramona M. Mohr, Ketema A. Daba, Thomas D. Warkentin, Mehri Hadinezhad, Brent Barlow, Anfu Hou, François Lefebvre, Ashkan Golshani, Elroy R. Cober, Bahram Samanfar, Bahram Samanfar   +16 more
doaj   +1 more source