Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor [PDF]
Nature Communications, 2016 Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Shili Xu +2 more
exaly +4 more sources
Nature Communications, 2020 Cancer cells can produce asparagine, yet both the regulation and biological functions of asparagine are unclear. Here the authors show that p53 suppresses asparagine synthesis and disrupts asparagine-aspartate homeostasis contributing to tumor growth ...
Xun Lan, Peng Jiang
exaly +3 more sources
SLC1A5 provides glutamine and asparagine necessary for bone development in mice
eLife, 2021 Osteoblast differentiation is sequentially characterized by high rates of proliferation followed by increased protein and matrix synthesis, processes that require substantial amino acid acquisition and production.
Deepika Sharma +4 more
doaj +2 more sources
Plants, 2022 Since the discovery of acrylamide in food, and the identification of free asparagine as the key determinant of acrylamide concentration in wheat products, our understanding of how grain asparagine content is regulated has improved greatly.
Joseph Oddy +4 more
doaj +2 more sources
Sex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase [PDF]
Pharmacological ResearchSex-related differences in asparagine metabolism are associated with cancer prognosis. However, the effect of exogenous asparagine on colorectal cancer (CRC) growth in men and women remains unclear.
Oladimeji Aladelokun +11 more
doaj +2 more sources
Asparagine Synthetase Gene OsASN2 Is Crucial for Rice Seed Development and Germination [PDF]
PlantsSeed development plays a critical role in determining both crop yield and grain quality in rice. As a key nutrient storage organ, the rice endosperm development not only contributes to grain filling but also plays an essential role during the early ...
Rui Hu +11 more
doaj +2 more sources
Potential of Hyperthermophilic L-Asparaginase from Thermococcus sibiricus to Mitigate Dietary Acrylamide Assessed Using a Simplified Food System [PDF]
FoodsThe Maillard reaction is a network of interconnected interactions yielding in formation a number of toxic derivatives in processed foods. Acrylamide, a potential carcinogen and a product of the Maillard reaction, is formed under food processing ...
Maria Dumina +2 more
doaj +2 more sources
Aspartate Metabolism Facilitates IL-1β Production in Inflammatory Macrophages
Frontiers in Immunology, 2021 Increasing evidence support that cellular amino acid metabolism shapes the fate of immune cells; however, whether aspartate metabolism dictates macrophage function is still enigmatic.
Hao Wang +9 more
doaj +1 more source
Assimilation of Nitrate into Asparagine for Transport in Soybeans
Agronomy, 2023 In this study, the systematic analysis of nitrate assimilation and transport in soybean roots was further improved by analyzing the concentrations of nitrate assimilates, asparagine and glutamine, in soybean roots and the related enzyme activities.
Sha Li +6 more
doaj +1 more source
Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress
Frontiers in Oncology, 2021 Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC cells consume large amounts of glutamine to survive, but can adapt to glutamine depletion in the presence of an exogenous asparagine.
Keiichiro Okuda +17 more
doaj +1 more source