Targeting the Proline–Glutamine–Asparagine–Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy [PDF]
Pharmaceuticals, 2021 Proline, glutamine, asparagine, and arginine are conditionally non-essential amino acids that can be produced in our body. However, they are essential for the growth of highly proliferative cells such as cancers.
Macus Tien Kuo +3 more
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Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor [PDF]
Nature Communications, 2016 Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Shili Xu +2 more
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Targeting asparagine potentiates anti-PD-L1 immunotherapy in gastric cancer by enhancing CD8+ T cell anti-tumor response [PDF]
Frontiers in ImmunologyIntroductionImmunotherapy efficacy in gastric cancer (GC) is often constrained by the tumor microenvironment (TME), which is profoundly influenced by aberrant metabolism. Asparagine, an amino acid critical for neoplastic proliferation, also modulates CD8+
Mingpai Ge +16 more
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Asparagine-related biomarkers and regulatory mechanisms in type 2 diabetes mellitus [PDF]
Frontiers in Molecular BiosciencesBackgroundType 2 diabetes mellitus (T2DM) is a complex metabolic disorder. Emerging evidence suggests asparagine metabolism might play a pivotal role in T2DM, yet the underlying molecular mechanisms remain elusive.
Jiayi Xia +5 more
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Aspartate Metabolism Facilitates IL-1β Production in Inflammatory Macrophages
Frontiers in Immunology, 2021 Increasing evidence support that cellular amino acid metabolism shapes the fate of immune cells; however, whether aspartate metabolism dictates macrophage function is still enigmatic.
Hao Wang +9 more
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Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress
Frontiers in Oncology, 2021 Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC cells consume large amounts of glutamine to survive, but can adapt to glutamine depletion in the presence of an exogenous asparagine.
Keiichiro Okuda +17 more
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SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis [PDF]
Cell Death and Disease, 2019 Weili Han, Dean Tian, Yongzhan Nie
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Assimilation of Nitrate into Asparagine for Transport in Soybeans
Agronomy, 2023 In this study, the systematic analysis of nitrate assimilation and transport in soybean roots was further improved by analyzing the concentrations of nitrate assimilates, asparagine and glutamine, in soybean roots and the related enzyme activities.
Sha Li +6 more
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SLC1A5 provides glutamine and asparagine necessary for bone development in mice
eLife, 2021 Osteoblast differentiation is sequentially characterized by high rates of proliferation followed by increased protein and matrix synthesis, processes that require substantial amino acid acquisition and production.
Deepika Sharma +4 more
doaj +1 more source
Cereal grain with low acrylamide formation potential as a raw material for safer cereal-based food products in Serbia [PDF]
Selekcija i Semenarstvo, 2022 The presence of acrylamide, a mutagen and a Group 2A carcinogen, in food, is a health concern that might raise cancer risk. Acrylamide is mainly formed in the Maillard reaction between free asparagine and reducing sugars, during industrial thermal food ...
Nikolić Valentina +6 more
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