Results 181 to 190 of about 101,970 (257)

Optimising Asparaginase Use and Managing Hypersensitivity in Australasia—A Clinical Practice Guideline From the Australian and New Zealand Children's Haematology/Oncology Group

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background Asparaginase is a critical component of modern multi‐agent chemotherapy regimens for paediatric acute lymphoblastic leukaemia and lymphoblastic lymphoma, with inadequate exposure leading to inferior patient outcomes. Objectives To develop a clinical practice guideline for the use of asparaginase products in the Australasian context.
Matthew J. O'Connor, Michelle Martin, Sarah M. Trinder, Draga Barbaric, Diane Hanna, Chow Y. Lai, Michael P. Osborn, Tim Prestige, Bryony Ross, Leanne Super, Thomas Walwyn, Stacie S. Wang, Andrew Wood, Andrew S. Moore, Rishi S. Kotecha, Siobhan Cross   +15 more
wiley   +1 more source

Interpretable multi-omics machine learning reveals drought-driven shifts in plant-microbe interactions. [PDF]

Environ Microbiome
Yoshioka H, Debeljak P, Prado S, Fuji Y, Ichihashi Y, Iwata H.   +5 more
europepmc   +1 more source

Evaluation of Torula Yeast (Candida utilis) Single Cell Proteins as a Partial Replacement for Soybean Meal in Broiler Diets: Effects on Productive Performance, Meat Quality Traits, and Plasma Metabolome

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Over recent years the use of yeast in feedstuffs has gained momentum due to novel developments in single‐cell proteins (SCPs). SCPs are considered a sustainable protein source, as their production enable to convert low‐value substrates (including industrial/agricultural wastes) into feed, with a related reduced environmental impact. This study
Jonathan Dayan, Marco Zampiga, Francesca Soglia, Luca Laghi, Elisa Benini, Massimiliano Petracci, Federico Sirri   +6 more
wiley   +1 more source

Comparative study on changes in serum amino acid metabolic profiles in mice exposed to perfluorooctanoic acid and sodium ρ-perfluorous nonenoxybenzene sulfonate. [PDF]

Sci Rep
Guo X, Jing N, Liang S, Wei Q, Cui W, Xiao Y, Yang H, Wang F.   +7 more
europepmc   +1 more source

A factorial multi‐layer analysis reveals non‐additive sulfur–iron interactions shaping metabolic and transcriptional responses in durum wheat

New Phytologist, EarlyView.
Working model of S‐dependent Fe stress integration in durum wheat. S availability acts as the main factor defining the metabolic and transcriptional state of the plant, whereas Fe mainly affects the intensity of these responses. This is particularly evident for OAS, methionine, citrate and asparagine, which accumulated most strongly under combined S ...
Eleonora Coppa, Mutsumi Watanabe, Moez Maghrebi, Giulia Quagliata, Alessandro Bruschini, Rainer Hoefgen, Youry Pii, Stefano Cesco, Gianpiero Vigani, Stefania Astolfi   +9 more
wiley   +1 more source

Systemic Effects of Nitrate, Asparagine, and Glutamine on Nodulation and Biological Nitrogen Fixation in Soybean. [PDF]

Plants (Basel)
Sun J, Zhao D, Li X, Yang L, Zhao W, Li S, Dong S.   +6 more
europepmc   +1 more source

The combination of morphogenic regulators BABY BOOM and GRF‐GIF improves maize transformation efficiency and promotes leaf regeneration

New Phytologist, EarlyView.
Maize regeneration via somatic embryogenesis by ectopic expression of morphogenic factors TaGRF4‐TaGIF1 and ZmBBM. Summary Transformation is an indispensable tool for plant genetics and functional genomics. Although stable transformation in maize is no longer a major obstacle, there remains a need for accessible and efficient methods for academic ...
Zongliang Chen, Jiaqi Zhou, Mary Galli, Sessen Daniel Iohannes, Theresa Clark, Juan M. Debernardi, Jorge Dubcovsky, David Jackson, Andrea Gallavotti   +8 more
wiley   +1 more source

<i>Asparagine synthetase (ASNS)</i> Drives Tumorigenicity in Small Cell Lung Cancer. [PDF]

Biomedicines
Jeong M, Kim BC, Choi HJ, Lee GT, Jang SM, Kim KB.   +5 more
europepmc   +1 more source

Cell‐Specific Expression and Cellular Compartmental Regulation in Camptothecin Biosynthesis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant secondary metabolites such as monoterpenoid indole alkaloids (MIAs) show tightly regulated biosynthesis and accumulation in specific organelles of distinct cell types. However, the cell‐specific expression patterns of anticancer MIA camptothecin biosynthetic genes in Ophiorrhiza pumila and the regulatory mechanisms of camptothecin ...
Xiaolong Hao, Yinkai Yang, Tiantian Chen, Xiaoxuan Fan, Yiqing Peng, Qingyan Ruan, Qin Zhou, Fanghao Liu, Jiayi He, Yongpeng Li, Yue Feng, Jiyan Qi, Guoyin Kai   +12 more
wiley   +1 more source