Results 11 to 20 of about 99,734 (259)
Asparagine Synthetase Chemotherapy [PDF]
Annual Review of Biochemistry, 2006 Modern clinical treatments of childhood acute lymphoblastic leukemia (ALL) employ enzyme-based methods for depletion of blood asparagine in combination with standard chemotherapeutic agents. Significant side effects can arise in these protocols and, in many cases, patients develop drug-resistant forms of the disease that may be correlated with up ...
Nigel G J, Richards, Michael S, Kilberg
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Amino Acids As Mediators of Metabolic Cross Talk between Host and Pathogen
Frontiers in Immunology, 2018 The interaction between host and pathogen decidedly shapes the outcome of an infection, thus understanding this interaction is critical to the treatment of a pathogen-induced infection.
Wenkai Ren +11 more
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Pharmaceuticals, 2021 Proline, glutamine, asparagine, and arginine are conditionally non-essential amino acids that can be produced in our body. However, they are essential for the growth of highly proliferative cells such as cancers.
Macus Tien Kuo +3 more
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Characterization of Three L-Asparaginases from Maritime Pine (Pinus pinaster Ait.)
Frontiers in Plant Science, 2017 Asparaginases (ASPG, EC 3.5.1.1) catalyze the hydrolysis of the amide group of L-asparagine producing L-aspartate and ammonium. Three ASPG, PpASPG1, PpASPG2, and PpASPG3, have been identified in the transcriptome of maritime pine (Pinus pinaster Ait ...
Sonia H. Van Kerckhoven +5 more
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Reducing the Risk of Acrylamide and Other Processing Contaminant Formation in Wheat Products
Foods, 2023 Wheat is a staple crop, consumed worldwide as a major source of starch and protein. Global intake of wheat has increased in recent years, and overall, wheat is considered to be a healthy food, particularly when products are made from whole grains ...
Navneet Kaur, Nigel G. Halford
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mBio, 2019 As obligate intracellular pathogens, viruses rely on the host cell machinery to replicate efficiently, with the host metabolism extensively manipulated for this purpose.
Chen-Hsuin Lee +6 more
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Plasma Amino Acids in Horses Suffering from Pituitary Pars Intermedia Dysfunction
Animals, 2022 Pituitary pars intermedia dysfunction is one of the most common diseases of aged horses and ponies. In Parkinson’s disease, which is, similar to PPID, a disease that involves oxidative damage to dopaminergic pathways but with different clinical signs ...
Sabita Diana Stoeckle +3 more
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Agronomy, 2018 In a two-year field trial, the effect of nitrogen (N) and sulfur (S) fertilization was investigated on grain yield, grain quality parameters, formation of acrylamide (AA), and the precursor free asparagine (Asn) in organically and conventionally produced
Falko Stockmann +5 more
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Cereal asparagine synthetase genes [PDF]
Annals of Applied Biology, 2020 AbstractAsparagine synthetase catalyses the transfer of an amino group from glutamine to aspartate to form glutamate and asparagine. The accumulation of free (nonprotein) asparagine in crops has implications for food safety because free asparagine is the precursor for acrylamide, a carcinogenic contaminant that forms during high‐temperature cooking and
Raffan, S., Halford, N. G.
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mBio, 2017 While glutamine is a nonessential amino acid that can be synthesized from glucose, some cancer cells primarily depend on glutamine for their growth, proliferation, and survival.
Ying Zhu +7 more
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