Results 11 to 20 of about 202,771 (390)
Asparagine: A Metabolite to Be Targeted in Cancers [PDF]
Metabolites, 2021 Amino acids play central roles in cancer progression beyond their function as building blocks for protein synthesis. Thus, targeting amino acid acquisition and utilization has been proved to be therapeutically beneficial in various pre-clinical models ...
Jie Jiang, S. Batra, Ji Zhang
semanticscholar +6 more sources
Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation [PDF]
JCI Insight, 2021 T cell receptor (TCR) triggering by antigen results in metabolic reprogramming that, in turn, facilitates the exit of T cells from quiescence. The increased nutrient requirements of activated lymphocytes are met, in part, by upregulation of cell surface ...
H. C. Hope +5 more
semanticscholar +6 more sources
Metabolism of asparagine in the physiological state and cancer
Cell Communication and SignalingAsparagine, an important amino acid in mammals, is produced in several organs and is widely used for the production of other nutrients such as glucose, proteins, lipids, and nucleotides.
Qiong Yuan +6 more
doaj +2 more sources
Asparagine Metabolic Pathways in Arabidopsis. [PDF]
Plant and Cell Physiology, 2016 Inorganic nitrogen in the form of ammonium is assimilated into asparagine via multiple steps involving glutamine synthetase (GS), glutamate synthase (GOGAT), aspartate aminotransferase (AspAT) and asparagine synthetase (AS) in Arabidopsis. The asparagine amide group is liberated by the reaction catalyzed by asparaginase (ASPG) and also the amino group ...
Laure Gaufichon, S. Rothstein, A. Suzuki
semanticscholar +5 more sources
Thermodynamic study of asparagine and glycyl-asparagine using computational methods [PDF]
Brazilian Archives of Biology and Technology, 2015 This work aimed to develop an ab initio procedure for accurately calculating pKa values and applied it to study the acidity of asparagine and glycyl-asparagine.
Farhoush Kiani +2 more
doaj +3 more sources
PTTG1 reprograms asparagine metabolism to promote hepatocellular carcinoma progression.
Cancer Research, 2023 Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a poor prognosis. Pituitary tumor transforming gene 1 (PTTG1) is highly expressed in HCC, suggesting it could play an important role in hepatocellular carcinogenesis ...
Qi Zhou +8 more
semanticscholar +1 more source
Asparagine protects pericentral hepatocytes during acute liver injury
Journal of Clinical Investigation, 2023 The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in ...
Yu Sun +9 more
semanticscholar +1 more source
Cell Death and Disease, 2022 The availability of asparagine is the limitation of cell growth and metastasis. Asparagine synthetase (ASNS) was an essential enzyme for endogenous asparagine products.
Dongjing Cai +7 more
semanticscholar +1 more source
Science Advances, 2022 Depletion of circulating asparagine with l-asparaginase (ASNase) is a mainstay of leukemia treatment and is under investigation in many cancers. Expression levels of asparagine synthetase (ASNS), which catalyzes asparagine synthesis, were considered ...
Manuel Grima-Reyes +12 more
semanticscholar +1 more source
Annals of Applied Biology, 2006 AbstractInterest in plant asparagine has rapidly taken off over the past 5 years following the report that acrylamide, a neurotoxin and potential carcinogen, is present in cooked foods, particularly carbohydrate‐rich foods such as wheat and potatoes which are subjected to roasting, baking or frying at high temperatures.
Lea, P. J. +4 more
openaire +2 more sources