Results 191 to 200 of about 182,632 (352)

l-Asparaginase Immobilized on Nanographene Oxide as an Efficient Nanobiocatalytic Tool for Asparagine Depletion in Leukemia Cells

Paulina Erwardt, Bartosz Szymczak, Marek Wiśniewski, Bartosz Maciejewski, Michał Świdziński, Janusz Strzelecki, Wiesław Nowak, Katarzyna Roszek   +7 more
openalex   +1 more source

A method to assess compositional bias in biological sequences and its application to prion-like glutamine/asparagine-rich domains in eukaryotic proteomes [PDF]

, 2003
Paul M. Harrison, Mark Gerstein
openalex   +1 more source

Asparagine Endopeptidase (δ Secretase), an Enzyme Implicated in Alzheimer’s Disease Pathology, Is an Inhibitor of Axon Regeneration in Peripheral Nerves [PDF]

, 2020
Arthur W. English, Xia Liu, Olivia C. Mistretta, Patricia J. Ward, Keqiang Ye   +4 more
openalex   +1 more source

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, EarlyView.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

Marine-derived L-asparaginase: unlocking marine power in anti-tumor therapeutics. [PDF]

Front Immunol
Gopalakrishnan R, Kannan K, Gunasekaran R, Ramachandran P, Ganapathy D, Sivaperumal P.   +5 more
europepmc   +1 more source

Supplementary parenteral arginine corrects hypoargininaemia and rebalances plasma amino acid profiles in very preterm infants receiving parenteral nutrition: A prospective study

Nutrition in Clinical Practice, EarlyView.
Abstract Background Plasma amino acid (AA) profiles in parenteral nutrition (PN)–dependent very preterm infants (VPIs) consistently show overprovision of essential AA (EAA) and arginine deficiency. This may have implications for growth and immune/inflammatory responses.
Frances Callaghan, Laura Burgess, Chandini Menon Premakumar, Diane McCarter, Eva Caamaño Gutièrrez, Daniel B. Hawcutt, Colin Morgan   +6 more
wiley   +1 more source

Targeting distinct amino acid metabolic vulnerabilities in IDH-mutant and IDH-wildtype gliomas. [PDF]

Acta Neuropathol Commun
Ohba S, Hirayama A, Teranishi T, Hitachi K, Yamaguchi H, Murayama K, Natsumeda M, Tateishi K, Tsuchida K, Wakimoto H, Saya H, Pieper R, Hirose Y.   +12 more
europepmc   +1 more source

An REMD and QM/MM study into the sequence effect on asparagine deamidation [PDF]

, 2012
Catak, Saron, Félix, Jan, Moors, Samuel, Pauwels, Ewald, Savvides, Savvas, Van Speybroeck, Veronique, Waroquier, Michel   +6 more
core   +1 more source

Asparagine synthetase modulates glutaminase inhibitor sensitivity through metabolic reprogramming and serves as a prognostic biomarker in hepatocellular carcinoma

Benjian Gao, Dongning Zheng, Zhihong Liu, Yuming Guo, Yuntao Ye, Chen Zhou, Fengyi Yang, Jie Liu, Guangnian Zhang, Guoying Feng, Yongfa Liu, Qiang Wang, Song Su, Xiaoli Yang, Bo Li   +14 more
openalex   +1 more source

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source