Results 21 to 30 of about 202,771 (390)
Plant Biotechnology Journal, 2021 Summary Free asparagine is the precursor for acrylamide, which forms during the baking, toasting and high‐temperature processing of foods made from wheat.
S. Raffan +13 more
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Chronoregulation by Asparagine Deamidation [PDF]
Science's STKE, 2007 Every asparagine in every protein undergoes nonenzymatic deamidation to aspartate or isoaspartate at a rate determined by the surrounding protein structure and cellular environment. Under physiologic conditions, the deamidation half-life of individual asparagines in proteins is proposed to range from less than a day to several centuries.
Weintraub, Steven J. +1 more
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Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues
EMBO Journal, 2021 Brown and beige fat are specialized for energy expenditure by dissipating energy from glucose and fatty acid oxidation as heat. While glucose and fatty acid metabolism have been extensively studied in thermogenic adipose tissues, the involvement of amino
Yingjiang Xu +10 more
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Asparagine Synthesis in Pea Leaves, and the Occurrence of an Asparagine Synthetase Inhibitor [PDF]
Plant Physiology, 1983 Asparagine is present in the mature leaves of young pea (Pisum sativum cv Little Marvel) seedlings, and is synthesized in detached shoots. This accumulation and synthesis is greatly enhanced by darkening. In detached control shoots, [(14)C]aspartate was metabolized predominantly to organic acids and, as other workers have shown, there was little ...
Kenneth W. Joy +2 more
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Asparagine Synthetase Chemotherapy [PDF]
Annual Review of Biochemistry, 2006 Modern clinical treatments of childhood acute lymphoblastic leukemia (ALL) employ enzyme-based methods for depletion of blood asparagine in combination with standard chemotherapeutic agents. Significant side effects can arise in these protocols and, in many cases, patients develop drug-resistant forms of the disease that may be correlated with up ...
Nigel G. J. Richards, Michael S. Kilberg
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MAPK signaling regulates c‐MYC for melanoma cell adaptation to asparagine restriction
EMBO Reports, 2021 Amino acid restriction is among promising potential cancer treatment strategies. However, cancer cells employ a multitude of mechanisms to mount resistance to amino acid restriction, which impede the latter’s clinical development.
G. Pathria +4 more
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Biotechnology and Bioengineering, 2021 Chinese hamster ovary (CHO) cell lines are grown in cultures with varying asparagine and glutamine concentrations, but further study is needed to characterize the interplay between these amino acids.
B. Kirsch +9 more
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Genes for asparagine metabolism in Lotus japonicus : differential expression and interconnection with photorespiration [PDF]
, 2017 Background: Asparagine is a very important nitrogen transport and storage compound in plants due to its high nitrogen/carbon ratio and stability.
Betti, Marco +5 more
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Amino Acids As Mediators of Metabolic Cross Talk between Host and Pathogen
Frontiers in Immunology, 2018 The interaction between host and pathogen decidedly shapes the outcome of an infection, thus understanding this interaction is critical to the treatment of a pathogen-induced infection.
Wenkai Ren +11 more
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Frontiers in Plant Science, 2023 Soybean is an important global source of plant-based protein. A persistent trend has been observed over the past two decades that soybeans grown in western Canada have lower seed protein content than soybeans grown in eastern Canada.
Julia C. Hooker +16 more
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