Results 101 to 110 of about 5,130,397 (333)
Advanced Science, EarlyView.Real‐time NMR spectroscopy is used to study JNK1‐dependent phosphorylation of the intrinsically disordered substrate JIP1, revealing eleven phosphosites with distinct phosphorylation efficiencies. The site‐specific phosphorylation rates are shown to be determined by both the sequence position of the phosphosites relative to the two kinase docking site ...
Thibault Orand +7 more
wiley +1 more source
Shipin yu jixieObjectiveTo study the flavor intensity of green tea after mixing the main flavor monomers.MethodsThree main catechins [epigallocatechin gallate (EGCG), epigallocatechin gallate (GCG), epicatechin gallate (ECG)] and three amino acid monomers (aspartic ...
RAN Qiansong +5 more
doaj +1 more source
Advanced Science, EarlyView.Arginine deficiency accelerates androgenetic alopecia. Serum metabolome shows reduced circulating arginine, while local metabolic disruption depletes follicular reserves, triggering reactive oxygen species (ROS) accumulation and mTOR suppression that induce hair miniaturization.
Shixin Duan +19 more
wiley +1 more source
Advanced Science, EarlyView.DNA‐Based Genetic and Non‐Genetic Tools for Receptor Engineering. This review highlights recent advances in DNA‐based strategies for receptor engineering, including genetic approaches like domain fusion and site‐directed mutagenesis, as well as non‐genetic methods using functional nucleic acids, DNA nanostructures, and dynamic DNA reactions.
Hexin Nan +4 more
wiley +1 more source
NH2-terminal amino acids of the serum lipoproteins of normal and hypercholesterolemic rabbits*
Journal of Lipid Research, 1960 Aspartic acid is the major and glutamic acid and serine are minor NH2-terminal amino acids of the lipoproteins of rabbit serum. No NH2-terminal amino acids other than these are found after prolonged cholesterol feeding.
B. Shore, V. Shore
doaj
GmSop20 Functions as a Key Coordinator of the Oil‐To‐Protein Ratio in Soybean Seeds
Advanced Science, EarlyView.This study investigates the seed oil‐to‐protein ratio as a comprehensive quality metric and identifies GmSop20 as a crucial regulatory gene through forward genetics methodologies. By integrating GmSop20 with superior haplotypes and using gene editing/overexpression, new strategies are provided for precisely tuning the seed oil‐to‐protein ratio, thereby
Haowei Zheng +17 more
wiley +1 more source
Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn’s disease
EMBO Molecular MedicineIntestinal fibrosis is the primary cause of disability in patients with Crohn’s disease (CD), yet effective therapeutic strategies are currently lacking.
Xuehua Li +22 more
doaj +1 more source
Synthesis of ∈-aspartyl-lysines and of isohexylamides of aspartic acid [PDF]
, 1958 D. L. Swallow +2 more
openalex +1 more source
Recent Developments in Nanoparticle‐Hydrogel Hybrid Materials for Controlled Release
Advanced Science, EarlyView.This review highlights recent advances in nanoparticle–hydrogel hybrid materials for controlled drug delivery. It explores diverse nanocarrier–hydrogel combinations, drug loading strategies, release mechanisms, and stimuli‐responsive behaviors. Emphasis is placed on the molecular interactions driving hybrid material performance, offering insights into ...
Yiping Fan +8 more
wiley +1 more source