Results 111 to 120 of about 138,442 (297)

Glycosylated dendrimer nanoamplifiers hijack DNA damage‐immune crosstalk for enhanced dual‐track therapy of orthotopic glioblastoma

BMEMat, EarlyView.
A glycosylated dendrimer nanoamplifier hijacks DNA damage‐immune crosstalk for enhanced radio‐immunotherapy of glioblastoma. The responsive release of demethylcantharidin simultaneously blocks repair‐mediated resistance by inhibiting DNA repair and overcomes adaptive immune resistance.
Cong Song, Binghan Liu, Junjie Liu, Ce Li, Wenqing Man, Xurui Sun, Chang Yuan, Yanjun Wang, Hong Pan, Shuanglian Wang, Zhiming Zheng   +10 more
wiley   +1 more source

Towards the directed evolution of an L-aspartate oxidase from Pseudomonas putida [PDF]

, 2012
Amino acid oxidases (AAOs) are enantioselective flavoenzymes that catalyse the oxidation of amino acids into imino acids, which spontaneously hydrolyse in water to form keto acids. AAOs have several potential applications, most notably as biocatalysts in
Leese, Charlotte
core  

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, EarlyView.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

Protein hydrolysates in cell culture: Toward multi‐omics characterization

Biotechnology Progress, EarlyView.
While protein hydrolysates are widely used in cell culture applications, they remain undefined and variable products. Multi‐omic characterization evaluating composition and function can transition hydrolysates toward semi‐defined media components.
Michelle Combe, Brandon M. Wrage, Angel Varela‐Rohena, Stanislav Sokolenko   +3 more
wiley   +1 more source

Occurrence and neuroendocrine role of D-aspartic acid and N-methyl-D-aspartic acid in Ciona intestinalis

, 2003
Probes for the occurrence of endogenous D-aspartic acid (D-Asp) and N-methyl-D-aspartic acid (NMDA) in the neural complex and gonads of a protochordate, the ascidian Ciona intestinalis, have confirmed the presence of these two excitatory amino acids and ...
SALVATORE D\'ANIELLO, MARIA M. DI FIORE, George H Fisher, Fisher, George H, Antimo D'Aniello, ANTONIETTA DE SIMONE, Spinelli, Patrizia, RAKESH K. RASTOGI, Rastogi, Rakesh K, Salvatore D'Aniello, Di Fiore, Maria M, Rakesh K Rastogi, ANTIMO D\'ANIELLO, Branno, Margherita, MARGHERITA BRANNO, RASTOGI, RAKESH KUMAR, De Simone, Antonietta, FRANCESCO ANIELLO, Aniello, Francesco, D’Aniello, Antimo, Maria M Di Fiore, PATRIZIA SPINELLI, D’Aniello, Salvatore   +22 more
core   +2 more sources

Stereoselective Synthesis of Optically Active Aspartic Acid from Derivatives of Fumaric Acid and Maleic Acid

, 1966
Stereoselective synthesis of optically active aspartic acid from derivatives of fumaric acid and maleic ...
Matsumoto, K., Harada, K.
core  

The transformation of tryptophan to aspartic acid in peptides

, 1987
The tryptophan side chain is transformed by in situ generated ruthenium(VIII), to that of aspartic acid, in good yields; a multi-step degradation sequence is suggested on the basis of the transformations of tetrahydrocarbazole to adipic acid, valine to ...
Ranganathan, Darshan, Ranganathan, Subramania, Bhattacharyya, Dipti   +2 more
core   +1 more source

Multifunctional Design of Solid Polymer Electrolytes: Paving the Way for High‐Performance All‐Solid‐State Batteries

Carbon Energy, EarlyView.
This review provides a comprehensive and systematic overview of the multifunctional design strategies for solid polymer electrolytes (SPEs), a pivotal component for enabling high‐performance all‐solid‐state batteries (ASSBs). It begins with a detailed classification of SPE systems and elaborates on their respective molecular design principles. The work
Bin Man, Yuzhen Zhao, Bo Fu, Yulong Zeng, Yinwen Chen, Qingrui Liu, Wenjing Luo, Xin Li, Xuewei Li, Zikang Zhang, Yun Zheng, Sijie Liu   +11 more
wiley   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Design of Fuel‐Dependent, Complex‐Coacervate‐Based Synthetic Cells

Chemistry – A European Journal, EarlyView.
Fuel‐dependent synthetic cells form and persist only in the presence of chemical fuel, decaying under starvation. We establish design rules for hexapeptide‐based coacervates, showing that tryptophan enhances polyanion binding, extends lifetime, and reduces waste sensitivity.
Anna‐Lena Holtmannspötter, Xiaoyao Chen, Yiyi Fu, Melisa Badem, Phillip S. Weiß, Nicolas Glück, Chase Kanitz, Veronika Rupp, Kaige Wang, Job Boekhoven   +9 more
wiley   +1 more source