Results 101 to 110 of about 124,711 (254)
Chemistry – A European Journal, EarlyView.Chemoenzymatic reactions using the siderophore synthetase DesD from Salinispora tropica and hydroxamic acid substrates (native, non‐native) with different multiplicities (monomer, dimer) and components (homo‐/heterodimer) followed different reaction trajectories, which biased the architectures of the chelator major products and indicated DesD contains ...
Callum A. Rosser +2 more
wiley +1 more source
Late‐Stage Modification of Halotryptophan‐Containing Peptides Via Negishi Cross‐Coupling
Chemistry – A European Journal, EarlyView.Negishi cross‐coupling provides access to the late‐stage functionalization of bromotryptophan‐containing peptides under comparatively mild conditions and is applicable to a range of peptide substrates in the investigated model systems. The examined alkyl iodides and variation of N‐terminal residues demonstrate the feasibility of the transformation in a
Laura Cerveson +2 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.A modular, de novo α/β‐peptide design strategy allows fine‐tuning of ligand properties, resulting in multivalent ligands that simultaneously target separate binding sites on the protein surface. ABSTRACT Protein‐protein interactions that regulate gene expression in the nucleus are increasingly recognized as potential therapeutic targets but present ...
Márk V. Tresztián +4 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley +1 more source
Chemistry – A European Journal, EarlyView.The influence of head‐to‐tail cyclization, as well as the effect of ring expansion with an additional glycine on lanmodulin‐inspired peptides on the structure and lanthanide (Ln)‐binding behavior was investigated. While the decrease of structural flexibility can indeed increase the Ln affinity and peptide pre‐organization, it does not lead to an ...
Sophie M. Gutenthaler‐Tietze +6 more
wiley +1 more source
ASPARTIC ACID DECARBOXYLATION BY RHIZOBIUM TRIFOLII [PDF]
Journal of Bacteriology, 1949 D, Billen, H C, Lichstein
openaire +3 more sources
Chemie Ingenieur Technik, EarlyView.Adsorbents for cations of copper, lead, mercury, and nickel are obtained via grafting polymer mesh with an acrylic acid copolymer and subsequent functionalization with an amino acid. A distinct influence of the type of amino acid on the adsorption occurs.
Claudia Adolfs +6 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira +5 more
wiley +1 more source
Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
Aspartic acid-facilitated remineralization: a bio-inspired alternative to fluoride for enamel repair. [PDF]
Front Bioeng BiotechnolIvanova A, Buzova V, Potapova D.
europepmc +1 more source