Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease
Advanced Science, EarlyView.The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su +12 more
wiley +1 more source
DmCatD, a cathepsin D-like peptidase of the hematophagous insect Dipetalogaster maxima (Hemiptera: Reduviidae): Purification, bioinformatic analyses and the significance of its interaction with lipophorin in the internalization by developing oocytes [PDF]
, 2018 DmCatD, a cathepsin D-like peptidase of the hematophagous insect Dipetalogaster maxima, is synthesized by the fat body and the ovary and functions as yolk protein precursor. Functionally, DmCatD is involved in vitellin proteolysis.
Arrese, Estela L. +8 more
core +1 more source
The Molecular Basis of Amino Acids Sensing
Advanced Science, EarlyView.Amino acids are essential as protein building blocks and signaling molecules, enabling metabolic regulation. Cells sense amino acid levels to control protein synthesis, maintain homeostasis, and adapt to nutritional changes. This review explores recent advances in amino acid sensing mechanisms across organisms, highlighting their roles in cellular ...
Cong Jiang +3 more
wiley +1 more source
PEPTIDE SOLUBILITY, STRUCTURE AND CHARGE POSITION EFFECT ON ADSORPTION BY ALUMINIUM HYDROXIDE
Revista Colombiana de Química, 2008 Solubility, structure and position of charges in a peptide antigen sequence can be mentioned as being amongst the basic features of adsorption. In order to study their effect on adsorption, seven analogue series were synthesized from a MSP-1 peptide ...
Mary Trujillo +2 more
doaj
Alleviation of Seawater Stress on Tomato by Foliar Application of Aspartic Acid and Glutathione [PDF]
Journal of Stress Physiology & Biochemistry, 2013 A pot experiment was carried out in the botanical garden of Faculty of Education, Ain Shams University, with the aim of studying the effect of salinity levels (4, 8 and 16% of diluted seawater) and foliar application of aspartic acid and/or glutathione ...
Samia Ageeb Akladious +1 more
doaj
Changes of Metabolites and Related Flavors in Mandarin Fish (Siniperca chuatsi) during 24 h of Refrigeration [PDF]
Shipin KexueThe study aimed to investigate the changes of metabolites and related flavors in the muscle of fresh mandarin fish (Siniperca chuatsi) during 24 h of postmortem refrigeration at 4 ℃ by ultra performance liquid chromatography coupled with high resolution ...
ZHOU Beibei, WU Minglin, JIANG Yangyang, SUN Yongxu, LI Haiyang, CUI Kai
doaj +1 more source
Novel highly-soluble peptide-chitosan polymers: Chemical synthesis and spectral characterization [PDF]
, 2006 Novel water-soluble polymers, N-(gamma-propanoyl-valin)-chitosan and N-(gamma-propanoyi-aspartic acid)-chitosan, were synthesized by reaction of low molecular weight chitosan with N-alpha-(3-bromopropanoyl)-valine and N-alpha-(3-bromopropanoyl)-aspartic ...
Batista, MKS +3 more
core +1 more source
A Novel OsMPK6‐OsMADS47‐PPKL1/3 Module Controls Grain Shape and Yield in Rice
Advanced Science, EarlyView.OsMADS47 is identified as a key regulator governing rice grain morphology. Phosphorylation‐dependent regulation of its activity directs the development of slender versus round grains, modulating both yield and appearance. This mechanism bridges cellular signaling with transcriptional regulation, establishing a molecular framework for grain optimization.
Jingjing Fang +9 more
wiley +1 more source
Detecting Electron Transport of Amino Acids by Using Conductance Measurement
Sensors, 2017 The single molecular conductance of amino acids was measured by a scanning tunneling microscope (STM) break junction. Conductance measurement of alanine gives out two conductance values at 10−1.85 G0 (1095 nS) and 10−3.7 G0 (15.5 nS), while similar ...
Wei-Qiong Li +8 more
doaj +1 more source
The free d-aspartic acid and d-glutamic acid content of sheep milk and sheep milk products [PDF]
, 2014 The role of D-amino acids of foods in the human health is a strongly discussed topic and usually, data came from the investigation of cow milk. We have studied the free D-aspartic acid and free D-glutamic acid content of sheep milk, heat-treated sheep ...
Bara-Herczegh Ottilia +4 more
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