Results 31 to 40 of about 138,442 (297)
Mutation of aspartic acid 262 on estrogen receptor abrogates estradiol signaling pathway
Gynecological Endocrinology, 2023 Objective ERα (estrogen receptor alpha) exerts nuclear genomic actions and membrane-initiated non-genomic effects. The mutation of aspartic acid into alanine in vitro revealed the critical role of aspartic acid 258 (corresponding to mouse amino acid site
Xingyan Xu +9 more
doaj +1 more source
The role of aspartic acid in reducing coral calcification under ocean acidification conditions
, 2020 Biomolecules play key roles in regulating the precipitation of CaCO3 biominerals but their response to ocean acidification is poorly understood. We analysed the skeletal intracrystalline amino acids of massive, tropical Porites spp.
Hintz, Chris +8 more
core +1 more source
Sarcopenia and aspartic acid magnesium
Journal of Physical Fitness and Sports Medicine, 2015 Sarcopenia from aging, inactivity, weightlessness, disease and malnutrition causes social problems due to associated physical dysfunction, a decrease in QOL, and risk of death.
Shigeru Yamada +4 more
doaj +1 more source
, 2019 A facile and two-step strategy was employed to synthesize a series of novel aspartic-acid-based ampholytic amphiphiles from sustainable and commercially viable substances as starting materials.
Bianca Pérez (3684007) +5 more
core +1 more source
Hydrogels Based on Poly(aspartic acid): Synthesis and Applications
, 2019 This review presents an overview on the recent progress in the synthesis, crosslinking, interpenetrating networks, and applications of poly(aspartic acid) (PASP)-based hydrogels.
Adelnia, Hossein +3 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
LXVIII.—The rotation of aspartic acid [PDF]
J. Chem. Soc., Trans., 1896 n ...
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
, 1994 L-Aspartic acid by successive N-tosylation, anhydride formation, and reduction was converted into (3S)-3-(tosylamino)butano-4-lactone (4). Electrophilic methylation of 4, subsequent iodo-esterification and nucleophilic methylation, followed by ...
Jefford, Charles +3 more
core +1 more source