Results 61 to 70 of about 5,130,397 (333)
A Potent, Versatile Disulfide-Reducing Agent from Aspartic Acid
Journal of the American Chemical Society, 2012 Dithiothreitol (DTT) is the standard reagent for reducing disulfide bonds between and within biological molecules. At neutral pH, however, >99% of DTT thiol groups are protonated and thus unreactive. Herein, we report on (2S)-2-amino-1,4-dimercaptobutane
John C. Lukesh +2 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto +2 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz +2 more
wiley +1 more source
Aspartic Acid Residue 51 of SaeR Is Essential for Staphylococcus aureus Virulence
Frontiers in Microbiology, 2018 Staphylococcus aureus is a common Gram-positive bacteria that is a major cause of human morbidity and mortality. The SaeR/S two-component sensory system of S. aureus is important for virulence gene transcription and pathogenesis.
Tyler K. Nygaard +9 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This study reports the development of bioinspired 2D crystalline Bionanozyme derived from a single nucleobase. It effectively mimics multienzyme activity to detect and remove phenolic pollutants, identify disease biomarkers with high sensitivity, and protect cells from oxidative stress.
Subrat Vishwakarma +8 more
wiley +1 more source
Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases
Advanced Healthcare Materials, EarlyView.This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun +9 more
wiley +1 more source
Designing the Next Generation of Biomaterials through Nanoengineering
Advanced Materials, EarlyView.Nanoengineering enables precise control over biomaterial interactions with living systems by tuning surface energy, defects, porosity, and crystallinity. This review highlights how these nanoscale design parameters drive advances in regenerative medicine, drug delivery, bioprinting, biosensing, and bioimaging, while outlining key translational ...
Ryan Davis Jr. +3 more
wiley +1 more source
Advanced Materials, EarlyView.Biomimetic 3D‐printed hydrogel bioadhesives (PTLAs) are designed to address the limitations of existing bioadhesives, offering solutions for challenging tissue adhesion and enhanced healthcare. These PTLAs feature robust wet/underwater tissue adhesion/sealing, superior freeze/pressure and infection resistance, and adaptive self‐healing/gelling capacity,
Qi Wu +4 more
wiley +1 more source
Spatially Controlled 3‐D Multiplexed Aptamer Patterning in Hydrogels
Advanced Materials Interfaces, EarlyView.A hydrogel platform based on norbornene‐functionalized polyvinyl alcohol enables high‐resolution, 3‐D multiplexed patterning of DNA aptamers via two‐photon polymerization. Two distinct aptamers are covalently immobilized with single micron‐scale precision across the x, y, and z dimensions.
Kevin Roost +9 more
wiley +1 more source
BiomoleculesMyocardial infarction (MI), including ST-segment elevation MI (STEMI) and non-ST-segment elevation MI (NSTEMI), is still a leading cause of death worldwide.
Jie Zhou +8 more
doaj +1 more source