Results 61 to 70 of about 222,384 (349)
Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics. [PDF]
PLoS ONE, 2016 We describe the identification of a novel, tumor-specific missense mutation in the active site of casein kinase 1α (CSNK1A1) using activity-based proteomics.
Eric S Okerberg +10 more
doaj +1 more source
Разработка и регистрация лекарственных средств, 2023 Introduction. Pharmacotherapy of cardiac arrhythmias is one of the urgent problems of modern medicine. The presence of serious side effects, in particular proarrhythmic action, limits the use of known antiarrhythmics in clinical practice.
S. M. Napalkova, O. V. Buyuclinskaya
doaj +1 more source
The Hierarchical Structure of Sheep Wool and Its Impact on Physical Properties
Advanced Functional Materials, EarlyView.Sheep wool, a prevalent α‐keratinous fiber, is an essential model for studying protein‐based fibers. Its genetic diversity across breeds enables the establishment of multiscale structure‐property relationships, uncovering previously elusive insights into wool's hierarchical structure.
Serafina R. France Tribe +9 more
wiley +1 more source
Aspartate kinase and the synthesis of aspartate-derived amino acids in wheat
Planta, 1978 Aspartate kinase (EC 2.7.2.4.) has been purified from 7 day etiolated wheat (Triticum aestivum L. var. Maris Freeman) seedlings and from embryos imbibed for 8 h. The enzyme was 50% inhibited by 0.25 mM lysine. In this study wheat aspartate kinase was not inhibited by threonine alone or cooperatively with lysine; these results contrast with those ...
Bright, S. W. J. +2 more
openaire +3 more sources
Advanced Functional Materials, EarlyView.A miniaturized, label‐free, and enzyme‐free biosensor (miR‐TFT) enables direct electrical detection of microRNA (miRNA) with single‐nucleotide specificity and a detection limit of 0.6 fM. Built on a tri‐channel In2O3/ZnO heterojunction and functionalized with bespoke peptide nucleic acid (PNA) probes, the device is robust, reusable, and compatible with
Wejdan S. Al Ghamdi +5 more
wiley +1 more source
Aberrant amino acid metabolism promotes neurovascular reactivity in rosacea
JCI Insight, 2022 Rosacea is a chronic skin disorder characterized by abnormal neurovascular and inflammatory conditions on the central face. Despite increasing evidence suggesting that rosacea is associated with metabolic disorders, the role of metabolism in rosacea ...
Tangxiele Liu +10 more
doaj +1 more source
The effects of added salt on the second virial coefficients of the complete proteome of E. coli [PDF]
, 2002 Bacteria typically have a few thousand different proteins. The number of proteins with a given charge is a roughly Gaussian function of charge - centred near zero, and with a width around ten (in units of the charge on the proton).
Richard P. Sear, Runcong K.
core +2 more sources
Advanced Functional Materials, EarlyView.Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz +3 more
wiley +1 more source
Utilization of Aspartic Acid and Asparagine by Yeast [PDF]
Nature, 1950 MUCH work has been carried out upon the mechanisms whereby yeast is able to utilize nitrogen from amino-acids for its nutrition, and the mechanisms worked out by Ehrlich and Stickland illustrating nitrogen uptake are well known1,2. These and other authors (for example, Thorne3) have been concerned with the value of amino-acids to yeasts simply as ...
D J Munns, J. White
openaire +3 more sources
In vitro increased respiratory activity of selected oral bacteria may explain competitive and collaborative interactions in the oral microbiome [PDF]
, 2017 Understanding the driving forces behind the shifts in the ecological balance of the oral microbiota will become essential for the future management and treatment of periodontitis. As the use of competitive approaches for modulating bacterial outgrowth is
Boon, Nico +6 more
core +3 more sources