Results 1 to 10 of about 68,617 (151)

Aspartic Cathepsin D Endopeptidase Contributes to Extracellular Digestion in Clawed Lobsters Homarus americanus and Homarus gammarus [PDF]

Marine Biotechnology, 2010
Acid digestive proteinases were studied in the gastric fluids of two species of clawed lobster (Homarus americanus and Homarus gammarus). An active protein was identified in both species as aspartic proteinase by specific inhibition with pepstatin A. It was confirmed as cathepsin D by mass mapping, N-terminal, and full-length cDNA sequencing.
Fernando García-Carreño, Adriana Muhlia-Almazan, Reinhard Saborowski   +2 more
exaly   +4 more sources

High molecular weight aspartic endopeptidase generates a coronaro-constrictory peptide from the β-chain of hemoglobin [PDF]

FEBS Letters, 1993
Studying the influence of brain cathepsin D (EC 3.4.23.5) and high molecular weight (HMW) aspartic endopeptidase (EC 3.4.23.‐) on the processing of hypothalamic calmodulin‐binding coronaro‐constrictory peptide factors from the β‐chain of globin it was found that only HMW aspartic endopeptidase generates the fragment 31–40 of the β‐chain of bovine ...
J Kellermann, A Galoyan
exaly   +4 more sources

Structural Studies of Aspartic Endopeptidase pep2 from Neosartorya Fisherica Using Homolgy Modeling Techniques [PDF]

International Journal on Bioinformatics & Biosciences, 2013
Aspartic endo peptidase pep2 protein of neosartorya fisherica belongs from aspartic acid proteases that depend on aspartic acid residues for their catalytic activity. Catalytic mechanism has been proposed for the hydrolysis of proteins to peptides or free amino acids.
Syed Farhan Ahmad
exaly   +5 more sources

Discovery and biochemical characterization of the D-aspartyl endopeptidase activity of the serine protease LACTB [PDF]

Journal of Biological Chemistry
Nonenzymatic D-isomerization of aspartic acid in proteins has been observed in lesions associated with age-related diseases, including cataracts and Alzheimer's disease.
Genta Itô, Naoko Utsunomiya-Tate
exaly   +3 more sources

A novel milk-clotting enzyme from Aspergillus oryzae and A. luchuensis is an aspartic endopeptidase PepE presumed to be a vacuolar enzyme

Bioscience, Biotechnology, and Biochemistry, 2022
ABSTRACT Aspergillus oryzae RIB40 has 11 aspartic endopeptidase genes. We searched for milk-clotting enzymes based on the homology of the deduced amino acid sequence with chymosins. As a result, we identified a milk-clotting enzyme in A. oryzae. We expected other Aspergillus species to have a homologous enzyme with milk-clotting activity,
Yoko, Takyu, Taro, Asamura, Ayako, Okamoto, Hiroshi, Maeda, Michio, Takeuchi, Ken-Ich, Kusumoto, Toru, Katase, Hiroki, Ishida, Mizuki, Tanaka, Youhei, Yamagata   +9 more
openaire   +3 more sources

Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases

Parasites & Vectors, 2008
Background Ticks are vectors for a variety of viral, bacterial and parasitic diseases in human and domestic animals. To survive and reproduce ticks feed on host blood, yet our understanding of the intestinal proteolytic machinery used to derive ...
Mareš Michael, Caffrey Conor R, Hajdušek Ondřej, Horn Martin, Franta Zdeněk, Sojka Daniel, Kopáček Petr   +6 more
doaj   +2 more sources

Bioinformatics Aided Elucidation of Functional and Structural Attributes of Bubalus Arnee Bubalis (BAB) Prochymosin

Food Bioengineering
The aspartic protease prochymosin, found in the abomasum of Bubalus arnee bubalis (BAB), is pivotal in κ‐casein cleavage at the Phe105‐Met106 site, facilitating milk coagulation and cheese production.
Raushan Kumar Jha, Prasun Choudhary, Adarsh Kumar Shukla, Surbhi Panwar, Ashwani Kumar   +4 more
doaj   +2 more sources

Analysis of toxicity and mechanisms of aspartame in kidney stones with network toxicology and molecular docking strategy [PDF]

Scientific Reports
Aspartame, an artificial sweetener, has been implicated in the formation of kidney stones, although the underlying mechanisms remain poorly understood.
Kailiang Xu, Qiuqiu Zhang, Zhihao Shen, Jinmin Zeng, Yixiang Liao   +4 more
doaj   +2 more sources

Male-specific behavioral and transcriptomic changes in aging C. elegans neurons

iScience
Summary: Aging is a complex biological process with sexually dimorphic aspects. Although cognitive aging of Caenorhabditis elegans hermaphrodites has been studied, less is known about cognitive decline in males. We found that cognitive aging has both sex-
Yifei Weng, Coleen T. Murphy
doaj   +2 more sources

Enhancing Consumer Acceptance of Cricket (<i>Acheta domesticus</i>) Protein Hydrolysate Through ProteAX-Mediated Enzymatic Hydrolysis to Improve Techno-Functional and Organoleptic Properties. [PDF]

Food Sci Nutr
ProteAX‐assisted hydrolysis of cricket (Acheta domesticus) protein enhanced its techno‐functional and sensory properties. Optimal hydrolysis at a 1.5% enzyme concentration for 5 h produced a hydrolysate with a 67.71% degree of hydrolysis, 69.51% protein content, high solubility, improved water and oil absorption capacities, low bitterness, and a strong
Fetriyuna F, Nushrotina R, Iwansyah AC, Sukri N, Purwestri RC.   +4 more
europepmc   +2 more sources