Results 21 to 30 of about 68,617 (151)

N-terminal entrance loop of yeast Yps1 and O-glycosylation of substrates are determinant factors controlling the shedding activity of this GPI-anchored endopeptidase

BMC Microbiology, 2015
BackgroundS. cerevisiae Yps1 is the prototypical aspartic endopeptidase of the fungal yapsin family. This glycosylphosphatidylinositol (GPI) anchored enzyme was recently shown to be involved in the shedding of the GPI proteins Utr2, Gas1 and itself.
A. K. Dubé, M. Bélanger, Isabelle Gagnon-Arsenault, Y. Bourbonnais   +3 more
semanticscholar   +2 more sources

Evolutionary histories of expanded peptidase families in Schistosoma mansoni

Memorias do Instituto Oswaldo Cruz, 2011
Schistosoma mansoni is one of the three main causative agents of human schistosomiasis, a major health problem with a vast socio-economic impact. Recent advances in the proteomic analysis of schistosomes have revealed that peptidases are the main ...
Larissa Lopes Silva, Marina Marcet-Houben, Adhemar Zerlotini, Toni Gabaldón, Guilherme Oliveira, Laila Alves Nahum   +5 more
doaj   +1 more source

Phosphorylated acidic serine–aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity [PDF]

Journal of Endocrinology, 2007
Inactivating PHEX (phosphate regulating gene with homologies to endopeptidases on the X chromosome) mutations cause X-linked hypophosphatemia in humans and mice (Hyp) through overproduction of fibroblast growth factor 23 (FGF23) a phosphaturic factor, by osteocytes.
Shiguang, Liu, Peter S N, Rowe, Luke, Vierthaler, Jianping, Zhou, L Darryl, Quarles   +4 more
openaire   +2 more sources

Cathepsin D Expression in Oral Squamous Cell Carcinoma and Cancer-Associated Fibroblasts: A Preliminary Study

치위생과학회지, 2021
Background: Cancer-associated fibroblasts (CAFs) are abundant in tumor microenvironments and interact with cancer cells to promote tumor proliferation in oral squamous cell carcinoma (OSCC).
Dokyeong Kim, Sook Moon
doaj   +1 more source

Homology modeling and functional annotation of bubaline pregnancy associated glycoprotein 2

Journal of Animal Science and Biotechnology, 2012
Background Pregnancy associated glycoproteins form a diverse family of glycoproteins that are variably expressed at different stages of gestation. They are probably involved in immunosuppression of the dam against the feto-maternal placentome.
Ganguly Bhaskar, Prasad Shiv
doaj   +1 more source

Enzymatic and Structural Characterization of the Major Endopeptidase in the Venus Flytrap Digestion Fluid*

Journal of Biological Chemistry, 2015
Carnivorous plants primarily use aspartic proteases during digestion of captured prey. In contrast, the major endopeptidases in the digestive fluid of the Venus flytrap (Dionaea muscipula) are cysteine proteases (dionain-1 to -4).
Flytrap Digestion, M. W. Risør, Line R. Thomsen, K. W. Sanggaard, Tania A. Nielsen, I. Thøgersen, M. V. Lukassen, L. Rossen, I. Garcia-Ferrer, T. Guevara, C. Scavenius, E. Meinjohanns, F. Gomis-Rüth, J. Enghild   +13 more
semanticscholar   +1 more source

Purification, Cloning and Immuno-Biochemical Characterization of a Fungal Aspartic Protease Allergen Rhi o 1 from the Airborne Mold Rhizopus oryzae.

PLoS ONE, 2015
BackgroundFungal allergy is considered as serious health problem worldwide and is increasing at an alarming rate in the industrialized areas. Rhizopus oyzae is a ubiquitously present airborne pathogenic mold and an important source of inhalant allergens ...
Gaurab Sircar, Bodhisattwa Saha, Rahul Shubhra Mandal, Naren Pandey, Sudipto Saha, Swati Gupta Bhattacharya   +5 more
doaj   +1 more source

Modulation of posterior intestinal mucosal proteome in rainbow trout (Oncorhynchus mykiss) after Yersinia ruckeri infection

Veterinary Research, 2019
Yersinia ruckeri is the causative agent of enteric redmouth disease in salmonids. In fish, the intestine represents an important site of nutrient uptake, host–pathogen interactions, and defense.
Gokhlesh Kumar, Karin Hummel, Ebrahim Razzazi-Fazeli, Mansour El-Matbouli   +3 more
doaj   +1 more source

Comprehensive bioinformatics-based annotation and functional characterization of bovine chymosin protein revealed novel biological insights

Food Chemistry: Molecular Sciences
Chymosin, an aspartic protease present in the stomachs of young ruminants like cows (bovine), causes milk coagulation and cheese production through the breakdown of κ-casein peptide bonds at the Met105-Phe106 site. Bovine chymosin is first synthesized as
Hafsa Amjad, Faiza Saleem, Munir Ahmad, Uzma Nisar, Hamza Arshad Dar   +4 more
doaj   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source