Results 11 to 20 of about 36,613 (150)

Exploring aspartic protease inhibitor binding to design selective antimalarials [PDF]

, 2022
Selectivity is a major issue in the development of drugs targeting pathogen aspartic proteases. Here we explore the selectivity determining factors by studying specifically designed malaria aspartic protease (plasmepsin) open-flap inhibitors ...
Sofija, Matisone, Victor, Andrianov, Iveta, Kanepe, Raitis, Bobrovs, Dace, Rasina, Emils, Basens, Diana, Zelencova-Gopejenko, Karlis, Velins, Kristaps, Jaudzems, Laura, Drunka, Gundars, Leitis, Aigars, Jirgensons   +11 more
core   +2 more sources

A neutron laue diffraction study of endothiapepsin: Implications for the aspartic proteinase mechanism [PDF]

, 2001
Current proposals for the catalytic mechanism of aspartic proteinases are largely based on X-ray structures of bound oligopeptide inhibitors possessing nonhydrolyzable analogues of the scissile peptide bond.
Myles, D. A. A., Erskine, P. T., Wood, S. P., L. Coates, Erskine, P.T., Wood, S.P., P. T. Erskine, Cooper, J. B., D. A. A. Myles, Coates, L., S. P. Wood, J. B. Cooper, Cooper, J.B., Myles, D.A.A.   +13 more
core   +1 more source

Glutamyl endopeptidase of Bacillus intermedius, strain 3-19 [PDF]

, 1997
A homogeneous glutamyl endopeptidase splitting peptide bonds of glutamic, rarely of aspartic acid residues in peptides and proteins, was isolated from Bacillus intermedius 3-19 culture filtrate using chromatography on CM cellulose and Mono S.
I.B. Leshchinskaya, Leshchinskaya, I.B., Sharipova, M.R., Stepanov, V.M., N.P. Balaban, Itskovitch, E.L., Rudenskaya, G.N., Mardanova, A.M., M.R. Sharipova, Viryasov, M.B., G.N. Rudenskaya, Shakirov, E.V., A.M. Mardanova, V.M. Stepanov, Balaban, N.P., E.L. Itskovitch, E.V. Shakirov, M.B. Viryasov   +17 more
core   +3 more sources

The aspartic proteinase family of three Phytophthora species [PDF]

, 2011
Background - Phytophthora species are oomycete plant pathogens with such major social and economic impact that genome sequences have been determined for Phytophthora infestans, P. sojae and P. ramorum.
Meijer, H.J.G., Have, A., ten, Kay, J., Kan, J.A.L., van   +3 more
core   +1 more source

Evolutionary histories of expanded peptidase families in Schistosoma mansoni

Memorias do Instituto Oswaldo Cruz, 2011
Schistosoma mansoni is one of the three main causative agents of human schistosomiasis, a major health problem with a vast socio-economic impact. Recent advances in the proteomic analysis of schistosomes have revealed that peptidases are the main ...
Larissa Lopes Silva, Marina Marcet-Houben, Adhemar Zerlotini, Toni Gabaldón, Guilherme Oliveira, Laila Alves Nahum   +5 more
doaj   +1 more source

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans [PDF]

, 2012
Aims - Inhibition of neutral endopeptidases (NEP) results in a beneficial increase in plasma concentrations of natriuretic peptides such as ANP.
Johnston, F., Maguire, J.J., Maguire, Janet J., Seed, Alison, Hanka J. de Voogd, Essers, H., Janet J. Maguire, Kuc, R.E., de Voogd, H.J., Kuc, Rhoda E., Seed, A., McMurray, J.J.V., Davenport, Anthony P., Hillier, Christopher, Rhoda E. Kuc, Anthony P. Davenport, Hillier, C., Hans Essers, Davenport, A.P., Alison Seed, Johnston, Fiona, John McMurray, Christopher Hillier, McMurray, John, Fiona Johnston, Essers, Hans, de Voogd, Hanka J.   +26 more
core   +1 more source

A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug l-asparaginase [PDF]

, 2009
l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism.
Vaskar Saha, Krishnan, S., Holland, Mark, Colin Watts, Mark Holland, Holland, M., Liu, JiZhong, Ariffin, Hany, Bates, P.A., Marcin Krol, Paul A. Bates, Moss, Catherine X., Patel, N., Essink, M., Patel, Naina, Clare Dempsey, Krishnan, Shekhar, van Delft, Frederik W., Watts, Colin, Carly Leighton, Leighton, Carly, Eden, T.O.B., Moss, C.X., Offman, Marc N., JiZhong Liu, Dempsey, Clare, Seema Alexander, Hany Ariffin, Bates, Paul A., Dempsey, C., Eden, Tim O B, Alexander, S., van Delft, F.W., Frederik W. van Delft, Watts, C., Offman, M.N., Saha, V., Leighton, C., Eden, Tim O.B., Saha, Vaskar; id_orcid, Shekhar Krishnan, Monika Essink, Saha, Vaskar, Krol, Marcin, Ariffin, H., Tim O.B. Eden, Naina Patel, Alexander, Seema, Catherine X. Moss, Krol, M., Marc N. Offman, Liu, J.Z., Essink, Monika, Van Delft, Frederik W, Offman, Marc N, Bates, Paul A, Moss, Catherine X, Dempsey, Clare E   +57 more
core   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Cathepsin D Expression in Oral Squamous Cell Carcinoma and Cancer-Associated Fibroblasts: A Preliminary Study

치위생과학회지, 2021
Background: Cancer-associated fibroblasts (CAFs) are abundant in tumor microenvironments and interact with cancer cells to promote tumor proliferation in oral squamous cell carcinoma (OSCC).
Dokyeong Kim, Sook Moon
doaj   +1 more source

The study of a new and specific proline cleaving peptidase from bovine serum [PDF]

, 2003
Prolyl oligopeptidase is a serine peptidase characterised by oligoendopeptidase activity. Definitive evidence for the discrete biological role of prolyl oligopeptidase remains unknown, though its role in the maturation and degradation of peptide hormones
Collins, Patrick
core   +1 more source