Results 161 to 170 of about 5,002 (185)

Advances in the Impact of ASS1 Dysregulation on Metabolic Reprogramming of Tumor Cells

Cellular Signalling
ASS1(argininosuccinate synthase 1) is a rate-limiting enzyme in the urea cycle, catalyzing the synthesis of argininosuccinate from citrulline and aspartate to ultimately produce arginine and support cellular metabolism. Increasing evidence suggests that ASS1 is commonly dysregulated in the tumor microenvironment, promoting tumor cell metastasis and ...
Asif Shahzad, Zhuoran Teng, Jiaojiao Xia
exaly   +3 more sources

Spinosyn A derivatives as ASS1 activators and tumor inhibitors

Bioorganic & Medicinal Chemistry Letters
Spinosad, a natural-origin pesticide, is extensively employed in agriculture and public health. Its primary component, Spinosyn A, has also attracted considerable interest due to its antiproliferative activity against various cancer cell lines. While ASS1 has emerged as a promising target for anticancer therapy, the development of ASS1 activators ...
Xin-Yu, Huang, Xiao-He, Liu, Na, Xu, Ting, Peng, Xi-Yuan, Hu, Min, Su, Zhi-Yong, Luo, Su-You, Liu, Da-You, Ma   +8 more
openaire   +2 more sources

Arginine deprivation for ASS1-deficient mesothelioma

The Lancet Oncology, 2016
www.thelancet.com/oncology Vol 17 October 2016 e423 Arginine deprivation therapy improves progression-free survival in patients with argininosuccinate synthetase 1 (ASS1)-defi cient malignant pleural mesothelioma, according to a new study . The investigators in the phase 2 trial screened 201 patients with mesothelioma from centres in the UK.
openaire   +1 more source

Polymorphic Variants of ASS1 Gene Related to Arginine Metabolism and the Risk of HCC

Protein & Peptide Letters, 2023
Background: Hepatocellular carcinoma is a primary liver cancer and 6th most common cancer globally. Inefficient diagnostic strategies and the limited availability of treatments are the foremost reasons. Variable factors directly impact the disease burden, among them, molecular alterations have been found to play a significant role.
Kulsoom Bibi, Tehseen Fatima, Saba Sohrab, Ghulam Haider, Shamshad Zarina, Amber Ilyas   +5 more
openaire   +2 more sources

ASS1 Deficiency Is Associated With Impaired Neuronal Differentiation in Zebrafish Larvae

Molecular Genetics and Metabolism
Citrullinemia type 1 (CTLN1) is a rare autosomal recessive urea cycle disorder caused by deficiency of the cytosolic enzyme argininosuccinate synthetase 1 (ASS1) due to pathogenic variants in the ASS1 gene located on chromosome 9q34.11. Even though hyperammenomia is considered the major pathomechanistic factor for neurological impairment and cognitive ...
Stefan Kolker, Matthias Zielonka, Roland Posset   +2 more
exaly   +3 more sources

99 Chinese ASS1 Carriers: Genetics, Metabolism, and Citrulline Levels

Clinica Chimica Acta
Citrullinemia type I is an autosomal recessive disorder caused by mutations in the ASS1 gene, whereas ASS1 mutation carriers typically have a mutation in only one allele. While carriers are usually asymptomatic, they often show mildly elevated plasma citrulline levels.
Lingwei HU, Xinwen Huang, Zhenzhen Hu
exaly   +3 more sources

Metabolic profiling of ASS1 negative and ASS1 positive glioblastoma subtypes to identify novel targets for therapy

2016
Glioblastoma multiforme (GBM) are the most common and most malignant brain tumours. Despite treatment advances, average survival remains unacceptably low with 15-months, hence novel therapies are desperately needed. Cellular metabolism plays a central role in cancers. Sensitivity towards arginine-deprivation via pegylated arginine deaminase (ADI-PEG20)
openaire   +2 more sources

Mutation spectrum of the ASS1 gene in Korean patients with citrullinemia type I

Clinical Biochemistry, 2013
Citrullinemia type I is a rare metabolic disorder and the distribution of mutations in the ASS1 gene varies among ethnic groups. We aimed to determine the molecular characteristics of citrullinemia type I in Korean patients.Biochemical and clinical findings were investigated and mutations in the ASS1 gene were identified using direct sequencing method ...
Hye In, Woo, Chang-Seok, Ki, Soo-Youn, Lee, Jong-Won, Kim, Junghan, Song, Dong-Kyu, Jin, Won Soon, Park, Dong Hwan, Lee, Yong-Wha, Lee, Hyung-Doo, Park   +9 more
openaire   +2 more sources

The Mechanism of TRIM21 Inhibiting the Invasion and Migration of ccRCC by Stabilizing ASS1

Molecular Carcinogenesis
ABSTRACTClear cell renal cell carcinoma (ccRCC) is characterized by its aggressive invasion and metastasis, presenting significant clinical challenges. Gaining insights into the molecular mechanisms underlying its progression is crucial for the development of effective therapeutic strategies.
Zhe Yang, Jihao Cai, Jingjing Li, Xiangjie Liu, Wenjing Liu, Kun Cui, Ziyuan Bai, Yurong Dong, Dongmei Peng, Qiuxin Duan, Asif Shahzad, Qiao Zhang   +11 more
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FoxO transcription factors regulate urea cycle through Ass1

Biochemical and Biophysical Research Communications
When amino acids are plentiful in the diet, the liver upregulates most enzymes responsible for amino acid degradation. In particular, the activity of urea cycle enzymes increases in response to high-protein diets to facilitate the excretion of excess nitrogen.
Samia Karkoutly, Yoshinori Takeuchi, Zahra Mehrazad Saber, Chen Ye, Duhan Tao, Yuichi Aita, Yuki Murayama, Akito Shikama, Yukari Masuda, Yoshihiko Izumida, Takashi Matsuzaka, Yasushi Kawakami, Hitoshi Shimano, Naoya Yahagi   +13 more
openaire   +2 more sources