Results 51 to 60 of about 208,150 (274)
Information theory and representation in associative word learning [PDF]
, 2003 A significant portion of early language learning can be viewed as an associative learning problem. We investigate the use of associative language learning based on the principle that words convey Shannon information about the environment.
Burns, Brendan +3 more
core
Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma. [PDF]
, 2020 Despite the large comorbidity between PTSD and opioid use disorders, as well as the common treatment of physical injuries resulting from trauma with opioids, the ability of opioid treatments to subsequently modify PTSD-related behavior has not been well ...
Evans, Christopher J +6 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Vicarious reward unblocks associative learning about novel cues in male rats
eLife, 2020 Many species, including rats, are sensitive to social signals and their valuation is important in social learning. Here we introduce a task that investigates if mutual reward delivery in male rats can drive associative learning.
Sander van Gurp +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Non-associative learning underlies pollination interaction of pollinators and flowering plants
National Science OpenThe behavioral response of pollinators is significantly influenced by the prior experience of flower visiting. Learning of pollinators, including non-associative learning, associative learning, and operant conditioning, is determined by the presence or ...
Zhang Wu-Fan, Luo Yi-Bo
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The pigeon as a machine: Complex category structures can be acquired by a simple associative model
iScience, 2023 Summary: Never known for its smarts, the pigeon has proven to be a prodigious classifier of complex visual stimuli. What explains its surprising success? Does it possess elaborate executive functions akin to those deployed by humans?
Brandon M. Turner, Edward A. Wasserman
doaj +1 more source
Associative concept learning in animals [PDF]
Journal of the Experimental Analysis of Behavior, 2013 Nonhuman animals show evidence for three types of concept learning: perceptual or similarity‐based in which objects/stimuli are categorized based on physical similarity; relational in which one object/stimulus is categorized relative to another (e.g., same/different); and associative in which arbitrary stimuli become interchangeable with one another by
Zentall, Thomas R +2 more
openaire +4 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source