Results 71 to 80 of about 208,150 (274)

The power of associative learning and the ontogeny of optimal behaviour [PDF]

Royal Society Open Science, 2016
Behaving efficiently (optimally or near-optimally) is central to animals' adaptation to their environment. Much evolutionary biology assumes, implicitly or explicitly, that optimal behavioural strategies are genetically inherited, yet the behaviour of ...
Magnus Enquist, Johan Lind, Stefano Ghirlanda   +2 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Associative learning of classical conditioning as an emergent property of spatially extended spiking neural circuits with synaptic plasticity

Frontiers in Computational Neuroscience, 2014
Associative learning of temporally disparate events is of fundamental importance for perceptual and cognitive functions. Previous studies of the neural mechanisms of such association have been mainly focused on individual neurons or synapses, often with ...
John ePalmer, Pulin eGong
doaj   +1 more source

Symbolic Versus Associative Learning [PDF]

Cognitive Science, 2010
AbstractRamscar and colleagues (2010, this volume) describe the “feature‐label‐order” (FLO) effect on category learning and characterize it as a constraint on symbolic learning. I argue that FLO is neither a constraint on symbolic learning in the sense of “learning elements of a symbol system” (instead, it is an effect on nonsymbolic, association ...
openaire   +2 more sources

Dynamical model of sequential spatial memory: winnerless competition of patterns

, 2002
We introduce a new biologically-motivated model of sequential spatial memory which is based on the principle of winnerless competition (WLC). We implement this mechanism in a two-layer neural network structure and present the learning dynamics which ...
A. Samsonovich, A.D. Redish, D. Kleinfeld, E.R. Wood, G. Bi, H. Eichenbaum, H. Markram, H. Sompolinsky, J. O’Keefe, J. O’Keefe, J.J. Hopfield, K.I. Blum, L.F. Abbott, Lev S. Tsimring, M. Rabinovich, M. Wilson, Mikhail I. Rabinovich, N.A. Scmjuk, Philip Seliger, R. Muller, T.V.P. Bliss   +20 more
core   +1 more source

Population-based incremental learning with associative memory for dynamic environments [PDF]

, 2008
Copyright © 2007 IEEE. Reprinted from IEEE Transactions on Evolutionary Computation. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Brunel University's ...
Yang, S, Yao, X
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Associative memory advantage in grapheme-colour synaesthetes compared to older, but not younger adults

Frontiers in Psychology, 2014
People with grapheme-colour synaesthesia perceive enriched experiences of colours in response to graphemes (letters, digits). In this study, we examined whether these synaesthetes show a generic associative memory advantage for stimuli that do not elicit
Gaby ePfeifer, Nicolas eRothen, Jamie eWard, Dennis eChan, Natasha eSigala   +4 more
doaj   +1 more source

Associative Learning: Hebbian Flies [PDF]

Current Biology, 2005
Fruit flies can learn to associate an odor with an aversive stimulus, such as a shock. New findings indicate that disrupting the expression of N-methyl-D-aspartate (NMDA) receptors in flies impairs olfactory conditioning. The findings provide support for a critical role for NMDA receptors in associative learning.
openaire   +2 more sources