Results 71 to 80 of about 1,879,088 (284)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Coupled neural associative memories [PDF]
2013 IEEE Information Theory Workshop (ITW), 2013 We propose a novel architecture to design a neural associative memory that is capable of learning a large number of patterns and recalling them later in presence of noise. It is based on dividing the neurons into local clusters and parallel plains, very similar to the architecture of the visual cortex of macaque brain.
Amin Karbasi +2 more
openaire +3 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Network Traffic Monitoring - an architecture using associative processing. [PDF]
, 1999 This paper investigates possible associative processing architectures for use in the implementation of a real time network traffic monitoring system.
Tripp, Gerald
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
On Learning Associative Relationship Memory among Knowledge Concepts
International Journal of Networked and Distributed Computing (IJNDC), 2020 A high-level associative memory modelling method was developed to explore the realization of associative memory. In the proposed method, two stage procedures are progressively performed to construct a unified associative knowledge network.
Zhenping Xie, Kun Wang, Yuan Liu
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Age-related changes in associative memory [PDF]
Older adults suffer from many cognitive impairments relative to young adults and one of the most established types of age-related cognitive decline is a reduction in memory performance.
Badham, Stephen P.
core
Mutation at the TrkB PLC{gamma}-docking site affects hippocampal LTP and associative learning in conscious mice [PDF]
, 2007 Previous in vitro studies have characterized the electrophysiological properties and molecular events associated with long-term potentiation (LTP), but as yet there are no in vivo data from molecular-level dissection that directly identify LTP as the ...
Delgado-García, José M +4 more
core +1 more source
Frontiers in PsychologyIntroductionOlder adults typically show a disproportionate decline in associative, relative to item, memory. Here, we investigated the role of stimulus presentation in a foreign language, as well as the impact of a unitization instruction for binding ...
Ricarda Endemann +7 more
doaj +1 more source