Results 131 to 140 of about 1,135 (159)

Research review on the pharmacological effects of astragalosideIV

Fundamental & Clinical Pharmacology, 2016
AbstractAstragalus membranaceus Bungehas been used to treat numerous diseases for thousands of years. As the main active substance ofAstragalus membranaceus Bunge, astragalosideIV(AS‐IV) also demonstrates the potent protective effect on focal cerebral ischemia/reperfusion, cardiovascular disease, pulmonary disease, liver fibrosis, and diabetic ...
Lei, Li, Xiaojiao, Hou, Rongfang, Xu, Chang, Liu, Menbayaer, Tu   +4 more
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Anti-stress effect of astragaloside IV in immobilized mice

Journal of Ethnopharmacology, 2014
Astragaloside IV, a major component extracted from the roots of Astragalus membranaceus (AM), possesses anti-inflammatory, anti-oxidative, anti-fibrotic, anti-infarction and immunoregulatory effects. To clarify anti-stress effect of AM, anxiolytic and anti-inflammatory effects of 80% ethanol extract of AM and astragaloside IV were investigated in ...
Hyun-A, Oh, Hyuck Jai, Choi, Nam Jae, Kim, Dong-Hyun, Kim   +3 more
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Mechanism of Astragaloside IV in Promoting Osteogenic Differentiation

Current Molecular Medicine
Background: This study focuses on exploring the impact of Astragaloside IV [AS-IV] on osteogenic differentiation. Methods: Osteogenic differentiation was induced in rat osteoblasts, following which treatment with AS-IV at varied doses ...
Yao, Zhu, Chengyu, Lin, Xudong, Zhang, Zuyun, Qiu, Lei, Shi, Jianmin, Li   +5 more
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Astragaloside IV in Hypoxic Pulmonary Hypertension: an In Vivo and In Vitro Experiments

Applied Biochemistry and Biotechnology, 2022
The objective of study was to find the actions of astragaloside IV (ASIV) on PAH due to monocrotaline (MCT) in rats. Intraperitoneal injection of 60 mg/ kg MCT was injected to rats, come after by ASIV treatment with doses of 10 mg/kg daily once or 30 mg/kg of dose for twenty one days once daily.
, XinTian, Xiaofeng, Zhang, Yi, Feng, Xiaolong, Gao, Xuan, Hao, Junru, Zhang, Yunhong, Long, , RongFang, Shumiao, Zhang, Ling, Li   +9 more
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Effects of Astragaloside IV on the Pharmacokinetics of Metoprolol in Rats and its Mechanism

Current Drug Metabolism, 2022
Backgrond: Astragaloside IV (AST) and metoprolol are often used together to treat cardiovascular diseases, while the herb-drug interaction (HDI) between them is still unclear. Objective: This study investigates the effect of AST on the pharmacokinetics of metoprolol in rats and its mechanism to predict the HDI.
Zhongbo Shi, Junhao Jiang, Dezhang Zhao, Baogang Xie, Yan Li, Chao Yu   +5 more
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Inhibitory effects of astragaloside IV on diabetic peripheral neuropathy in rats

Canadian Journal of Physiology and Pharmacology, 2006
Astragaloside IV (AGS-IV), a new glycoside of cycloartane-type triterpene isolated from the root of Astragalus membranaceus (Fisch.) Bunge, has been used experimentally for its potent immune-stimulating, anti-inflammatory, and antioxidative actions. A recent study has shown AGS-IV to be an aldose-reductase inhibitor and a free-radical scavenger.
Junxian, Yu, Yindi, Zhang, Shi, Sun, Jianping, Shen, Jun, Qiu, Xiaoxing, Yin, Honglin, Yin, Shaojun, Jiang   +7 more
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Mechanism of Astragaloside IV in Treatment of Renal Tubulointerstitial Fibrosis

Chinese Journal of Integrative Medicine
Tubulointerstitial fibrosis (TIF) is one of the key indicators in evaluating the renal function of patients. Mild TIF can cause a vicious cycle of renal tubular glomerular injury and aggravate renal disease. Therefore, studying the mechanisms underlying TIF is essential to identify therapeutic targets, thereby protecting the renal function of patients ...
Xin-Ru, Wang, Jing-Xiang, Luan, Zhao-An, Guo   +2 more
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Astragaloside IV prevents lipopolysaccharide-induced injury in H9C2 cardiomyocytes

Chinese Journal of Natural Medicines, 2015
This study aimed to investigate the protective effects of astragaloside IV (AS IV) on lipopolysaccharide (LPS)-induced injury in H9C2 cardiomyocytes. H9C2 Cardiomyocytes were cultured with LPS (10 μg·mL(-1)) for 4 h and treated with AS IV at 50, 100, and 150 μmol·L(-1) for various durations. Cell viability was determined by MTT. The content of released
Shi-Guang, Wang, Yan, Xu, Hao, Xie, Wei, Wang, Xiao-Hu, Chen   +4 more
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Effect of High Magnesium and Astragaloside IV on Vascular Endothelial Cells

Cell Biochemistry and Biophysics
Percutaneous coronary intervention (PCI) is the main treatment for patients with severe coronary vascular stenosis. However, In-stent neo-atherosclerosis (ISNA) is an important clinical complication in patients after PCI, which is mainly caused by a persistent inflammatory response and endothelial insufficiency.
Hongfei, Qi, Teng, Ge, Kun, Wang, Jing, Wang, Lin, Dang, Juane, Li, Haifang, Wang   +6 more
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[Study on new extraction technology of astragaloside IV].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2006
To explore the possibility and the optimal extraction technology of astragaloside IV by SFE-CO2.According the content of astragaloside IV, the optimum extraction technology parameters such as extraction temperature, pressure, extraction time, velocity of fluid and co-solvent were investigated and the result was compared with that of water extraction ...
Haiyan, Sun, Su, Guan, Min, Huang
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