Results 41 to 50 of about 1,135 (159)

Treatment with astragaloside IV reduced blood glucose, regulated blood lipids, and protected liver function in diabetic rats

Journal of International Medical Research, 2021
Objectives To investigate the effects of astragaloside IV on blood glucose, blood lipids, and liver function in diabetic rats. Methods Fifty diabetic rats were randomly placed into five groups (n = 10 each): the diabetes mellitus (DM) group received ...
Dong Han
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Heterologous Expression of Three Transcription Factors Differently Regulated Astragalosides Metabolic Biosynthesis in Astragalus membranaceus Hairy Roots

Plants, 2022
Astragalus membranaceus has been used as a highly popular Chinese herbal medicine for centuries. Triterpenoids, namely astragalosides I, II, III, and IV, represent the main active compounds in this plant species.
Xiao Hua Li, Jae Kwang Kim, Sang Un Park
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Astragaloside IV inhibits experimental autoimmune encephalomyelitis by modulating the polarization of both microglia/macrophages and astrocytes

, 2023
Astragaloside IV (AST IV), a major saponin component and active ingredient isolated from Astragalus membranaceus, has been well known to exhibit neuroprotective effects on diverse models of neurological diseases.
Yuqing Yan, Jiezhong Yu, Minfang Guo, Chunyun Liu, Cungen Ma, Jingwen Yu, Bingtao Mu, Gajendra Kumar, Tao Meng, Lijuan Song   +9 more
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Astragaloside IV enhances the sensitivity of breast cancer stem cells to paclitaxel by inhibiting stemness [PDF]

, 2023
Background: Chemotherapy is one of the common treatments for breast cancer. The induction of cancer stem cells (CSCs) is an important reason for chemotherapy failure and breast cancer recurrence. Astragaloside IV (ASIV) is one of the effective components
Heloisa Sobreiro Selistre-de-Araujo, Yuyu Hu, Qian Zuo, Liping Ren, Yuqi Liang, Stergios Boussios, Ping Huang, Rutao Cui, Liushan Chen, Sachin R. Jhawar, Qianjun Chen, Haimei Xie, Huachao Li   +12 more
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Astragalus saponins and its main constituents ameliorate ductular reaction and liver fibrosis in a mouse model of DDC-induced cholestatic liver disease

Frontiers in Pharmacology, 2022
Cholestatic liver disease (CLD) is a chronic liver disease characterized by ductular reaction, inflammation and fibrosis. As there are no effective chemical or biological drugs now, majority of CLD patients eventually require liver transplantation ...
Linzhang Zhang, Yonghong Hu, Shenglan Qi, Congcong Zhang, Qun Zhou, Dingqi Zhang, Yongping Mu, Hua Zhang, Gaofeng Chen, Ping Liu, Jiamei Chen, Wei Liu, Wei Liu   +12 more
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Astragaloside IV inhibits astrocyte senescence: implication in Parkinson’s disease [PDF]

Journal of Neuroinflammation, 2020
Abstract Background Senescent astrocytes have been implicated in the aging brain and neurodegenerative disorders, including Parkinson’s disease (PD). Astragaloside IV (AS-IV) is an antioxidant derivative from a traditional Chinese herbal medicine Astragalus membraneaceus Bunge and exerts anti-inflammatory and longevity effects and neuroprotective ...
Mei-Ling Xia, Xia-Hong Xie, Jian-Hua Ding, Ren-Hong Du, Gang Hu   +4 more
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Astragaloside IV: A promising natural neuroprotective agent for neurological disorders

Biomedicine & Pharmacotherapy, 2023
Neurological disorders are characterized by high morbidity, disability, and mortality rates, which seriously threaten human health. However, clinically satisfactory agents for treatment are still currently lacking. Therefore, finding neuroprotective agents with minimum side effects and better efficacy is a challenge.
Min Yao, Lijuan Zhang, Lin Wang
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Integrating Network Pharmacology and Experimental Validation to Explore the Pharmacological Mechanism of Astragaloside IV in Treating Bleomycin-Induced Pulmonary Fibrosis

Drug Design, Development and Therapy, 2023
Su Yuan,1,2 Biao Zuo,2,3 Si-Cong Zhou,1,2 Meng Wang,2,3 Kai-Yue Tan,2,3 Zhi-Wei Chen,2,3 Wen-Fu Cao1– 3 1Department of Combination of Chinese and Western Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s ...
Yuan S, Zuo B, Zhou SC, Wang M, Tan KY, Chen ZW, Cao WF   +6 more
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Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
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Chemical structure of astragaloside IV.

, 2014
Chemical structure of astragaloside IV.
Ning Jia (520422), Hui Jin (38113), Qinru Sun (573895), Weixi Wang (573896), Jiehua Xu (573897), Haitao Hu (456931)   +5 more
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