Results 31 to 40 of about 1,135 (159)

Effects of Astragaloside IV on heart failure in rats [PDF]

Chinese Medicine, 2009
Astragaloside IV (ASI) in Radix Astragali is believed to be the active component in treating heart failure. The present study aims to examine the effects of ASI on cardiovascular parameters in long-term heart failure in rats.Using echocardiographic and haemodynamic measurements, we studied the effects of ASI on congestive heart failure (CHF) induced by
Xu Weiren, Han Yingmei, Zhao Kerui, Wang Fang, Wang Weiting, Zhao Zhuanyou, Tang Lida   +6 more
openaire   +3 more sources

Research progress on the mechanism of astragaloside IV in the treatment of asthma

Heliyon, 2023
Asthma is a common chronic respiratory disease, and its treatment is a core problem and challenge in clinical practice. Glucocorticoids (GCs) are the first-line therapy for the treatment of asthma. Local and systemic adverse reactions caused by GCs create obstacles to the treatment of asthma.
Fanyi Yuan, Yang Yang, Li Liu, Pengcheng Zhou, Yi Zhu, Yilu Chai, Keling Chen, Wenjun Tang, Qingsong Huang, Chuantao Zhang   +9 more
openaire   +3 more sources

Molecular mechanisms of astragaloside‑IV in cancer therapy (Review)

International Journal of Molecular Medicine, 2021
Radix Astragali (RA) is widely used in traditional Chinese medicine (TCM), and astragaloside IV (AS‑IV) is the most critical component of RA. Previous studies have demonstrated that AS‑IV exerts effects on the myocardium, nervous system and endocrine system, among others. In the present review article, data from studies conducted over the past 20 years
Tianqi Chen, Peiying Yang, Yingjie Jia
openaire   +3 more sources

An updated role of astragaloside IV in heart failure

Biomedicine & Pharmacotherapy, 2020
Heart failure (HF) has become a worldwide public health problem that seriously threatens human's health. Due to "multi-target" effect, traditional Chinese medicine (TCM) has unique advantages in this field. Chinese herb-derived active components would provide valuable candidate compounds for new drug development.
Yibei, Zang, Jingjing, Wan, Zhen, Zhang, Si, Huang, Xia, Liu, Weidong, Zhang   +5 more
openaire   +2 more sources

Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats [PDF]

Pharmaceutical Biology, 2019
Context: Omeprazole and astragaloside IV (AS-IV) are widely used for the treatment of gastric ulcers in China clinics. Objective: This study investigates the effects of AS-IV on the pharmacokinetics of omeprazole in rats. Materials and methods: The pharmacokinetics of orally administered omeprazole (2 mg/kg), with or without AS-IV (100 mg/kg/day for 7 ...
Wei Liu, Guozhi Liu, Jing Liu
openaire   +3 more sources

Research progress of astragaloside IV in the treatment of atopic diseases

Biomedicine & Pharmacotherapy, 2022
Atopic disease is a kind of abnormal immune reaction caused by tissue damage and physiological dysfunction caused by allergens. Atopic diseases involve many systems and have obvious genetic tendencies, threatening the quality of life, health, and life safety of human beings.
Shencun, Yu, Wendong, Peng, Fanghong, Qiu, Guiju, Zhang   +3 more
openaire   +2 more sources

In Silico Prediction of Molecular Targets of Astragaloside IV for Alleviation of COVID-19 Hyperinflammation by Systems Network Pharmacology and Bioinformatic Gene Expression Analysis

Frontiers in Pharmacology, 2020
IntroductionThe overproduction of cytokines and chemokines caused by excessive and uncontrolled inflammation contributes to the development of COVID-19. Astragaloside IV is considered as an anti-inflammatory and antioxidant agent.
Chenliang Ge, Chenliang Ge, Yan He
doaj   +1 more source

Gastroprotective Effects of Astragaloside IV against Acute Gastric Lesion in Rats. [PDF]

PLoS ONE, 2016
BACKGROUND:Protection of the gastric mucosa from acute lesions induced by various irritants is a pertinent issue in the field of critical care medicine.
Shuai Mao, Guang Yang, Winny Li, Jian Zhang, Hailong Liang, Jian Li, Minzhou Zhang   +6 more
doaj   +1 more source

Effects of Astragaloside IV on diabetic nephropathy in rats

Genetics and Molecular Research, 2015
The aims of this study were to explore the effects of Astragaloside IV on diabetic nephropathy (DN) rats. A total of 38 male Sprague-Dawley (SD) rats were divided into three groups: 10 in the normal (control) group, 14 in the DN model group, and 14 in the AS-IV group.
W-S, Lu, S, Li, W-W, Guo, L-L, Chen, Y-S, Li   +4 more
openaire   +2 more sources

Research on the interaction of astragaloside IV and calycosin in Astragalus membranaceus with HMGB1

Chinese Medicine, 2023
Background High mobility group box 1 protein (HMGB1), a lethal late inflammatory mediator, contributes to the pathogenesis of diverse inflammatory and infectious diseases.
Junyi Ye, Yong Huang, Xuewa Jiang, Pingping Shen, Chaofeng Zhang, Jian Zhang   +5 more
doaj   +1 more source