Results 11 to 20 of about 1,135 (159)

Anti-Fibrotic Effects of Astragaloside IV in Systemic Sclerosis [PDF]

Cellular Physiology and Biochemistry, 2014
Objective: To evaluate the anti-fibrotic effects of Astragaloside IV in systemic sclerosis. Methods: Treated or untreated systemic sclerosis (SSc) and normal fibroblast isolated from corresponding pairs were utilized to detect expression of collagen and ...
Qing Qi, Yueping Mao, Juanjuan Yi, Donghai Li, Ke Zhu, Xushan Cha   +5 more
doaj   +4 more sources

Roles and Mechanisms of Astragaloside IV in Combating Neuronal Aging [PDF]

Aging and disease, 2022
Aging can lead to changes in the cellular milieu of the brain. These changes may exacerbate, resulting in pathological phenomena (including impaired bioenergetics, aberrant neurotransmission, compromised resilience and neuroplasticity, mitochondrial ...
Zhang, D., Wong, Wing-Tak, Zaman, Q., Wong, W.-T., Lai, W.-F., Reddy, Obireddy Sreekanth, Zaman, Qumar, Zhang, Dahong, Lai, Wing-Fu, Reddy, O.S.   +9 more
core   +5 more sources

Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts through regulation of the HOXA6/ZBTB12 axis

Acta Pharmaceutica, 2023
Cancer-associated fibroblasts (CAFs) play critical roles in the tumor microenvironment and exert tumor-promoting or tumor-retarding effects on cancer development.
Liu Haibo, Luo Shicheng, Sha Xiaofeng, Chen Zhiping, Yang Dongdong   +4 more
doaj   +3 more sources

Beneficial effects of Astragaloside IV for hair loss via inhibition of Fas/Fas L-mediated apoptotic signaling.

PLoS ONE, 2014
Apoptosis with premature termination of hair follicle growth induces several types of hair loss and is one of the crucial factors of hair loss. Astragaloside IV, which is a major component of Astragalus membranaceus, is a cycloartane triterpene saponin ...
Mi Hye Kim, Sung-Hoon Kim, Woong Mo Yang
doaj   +2 more sources

Astragaloside IV Enhances Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of B7-H3

Cellular Physiology and Biochemistry, 2016
Background: Chemoresistance is a major obstacle to successful chemotherapy for human non-small cell lung cancer (NSCLC). Astragaloside IV, the component of Astragalus membranaceus, has been reported to exhibit anti-inflammation, anti-cancer and ...
Cheng-Shi He, Yi-Cheng Liu, Zhi-Peng Xu, Peng-Chen Dai, Xiao-Wei Chen, De-Hai Jin   +5 more
doaj   +2 more sources

Astragalosidic Acid: A New Water-Soluble Derivative of Astragaloside IV Prepared Using Remarkably Simple TEMPO-Mediated Oxidation

Molecules, 2017
There is an urgent need for a water-soluble derivative of astragaloside IV for drug R&D. In the present study, a remarkably simple method for the preparation of such a water-soluble derivative of astragaloside IV has been developed.
Lin-Sen Qing, Shu-Lin Peng, Jian Liang, Li-Sheng Ding   +3 more
doaj   +3 more sources

Pharmacological Effects of Astragaloside IV: A Review

Molecules, 2023
Astragaloside IV (AS-IV) is one of the main active components extracted from the Chinese medicinal herb Astragali and serves as a marker for assessing the herb’s quality.
Shuchen Liu, Yunbo Sun, Yutong Liang, Xiaoxiao Quan, Zhuona Wu, Zhiyun Meng, Biqiong Chen, Di Liang, Ruolan Gu, Guifang Dou, Hui Gan   +10 more
core   +4 more sources

Astragaloside IV sensitizes non–small cell lung cancer cells to gefitinib potentially via regulation of SIRT6

Tumor Biology, 2017
Astragaloside IV, the active component of Astragalus membranaceus , exhibits diverse biological roles including the anti-tumor activity. In this study, we evaluated the chemosensitive role of astragaloside IV in non–small cell lung cancer cells.
Peng-Chen Dai, De-Ling Liu, Lei Zhang, Jia Ye, Qing Wang, Hong-Wen Zhang, Xiu-Hua Lin, Guo-Xiang Lai   +7 more
doaj   +2 more sources

Effect of astragaloside IV on indoxyl sulfate-induced kidney injury in mice via attenuation of oxidative stress

BMC Pharmacology and Toxicology, 2018
Background Astragalus membranaceus, a traditional Chinese medicine (TCM), has been widely used in the treatment of chronic kidney disease (CKD) in China. Astragaloside IV is one of the major compounds of Astragalus membranaceus. Recent research has shown
Chunlan Ji, Yueming Luo, Chuan Zou, Lihua Huang, Ruimin Tian, Zhaoyu Lu   +5 more
doaj   +2 more sources

Synthesis and evaluation of artificial antigens for astragaloside IV

Revista Brasileira de Farmacognosia, 2014
The objective of this study was to produce artificial antigens for astragaloside IV that could be used to prepare antibodies against astragaloside IV screened in Radix astragali (Astragalus membranaceus (Fisch) Bunge, Fabaceae) and its preparations ...
Yu, Sheng-lan, Meng, Ting, Xu, Jia-bing, Ou-yang, Zhen   +3 more
core   +4 more sources