Results 71 to 80 of about 1,135 (159)

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Astragaloside IV promotes haematopoiesis and enhances cytokines release by mesenchymal stromal cells mediated immune regulation

, 2012
Although tremendous efforts have been made to search for other novel growth factors in promoting marrow recovery after irradiation or chemotherapy, there have not been any efficient and safe agents discovered so far.
Deng, Ruixia, 邓瑞霞
core   +1 more source

Rosa roxburghii‐Derived Exosome‐Like Nanovesicles Alleviate Ulcerative Colitis Based on Th17/Treg Immune Balance and Gut Microbiota Modulation

Food Frontiers, Volume 7, Issue 3, May 2026.
Rosa roxburghii‐derived exosome‐like nanovesicles target the intestine, repairing barriers, regulating gut microbiota, balancing Th17/Treg, and combating oxidative stress/inflammation to alleviate colitis, a promising UC therapy. ABSTRACT Plant‐derived nanovesicles (PDVs), an innovative and bioactive form of natural products, are key mediators of ...
Yuanyuan Wang, Yan Zeng, Guoying Liu, Hai Zou, Jie Wang, Jun Zhang, Ketao Jin, Zhangfeng Zhong, Xiaozhou Mou   +8 more
wiley   +1 more source

Astragaloside IV Reprograms Spatial Glycolytic Metabolism in Diabetic Kidney: A Microenvironment‐Targeted Immunometabolic Therapeutic Strategy

Food Frontiers, Volume 7, Issue 3, May 2026.
Diabetic nephropathy (DN) is driven by spatially organized immunometabolic dysfunction. Integrating high‐resolution spatial transcriptomics (10× Visium HD) and metabolomics (MALDI‐MSI), we mapped a pathogenic glycolytic blockade within diabetic kidney microenvironments.
Shi Qiu, Zhibo Wang, Sifan Guo, Dandan Xie, Ying Cai, Xian Wang, Yan Wang, Xiaodan Yu, Jinxuan Chai, Hong Yao, Chunsheng Lin, Qiang Yang, Yu Guan, Qiqi Zhao, Songqi Tang, Wenjie Sun, Yiqiang Xie, Aihua Zhang   +17 more
wiley   +1 more source

Astragaloside IV Alleviates Ammonia-Induced Apoptosis and Oxidative Stress in Bovine Mammary Epithelial Cells

, 2019
Ammonia is one of the major toxic components of metabolites in blood and tissues of high-producing dairy cows and could affect the health of bovine mammary glands.
Liting Sun, Maosheng Cao, Chunjin Li, Lu Chen, Fengge Wang, Shuxiong Chen, Yun Zhao, Xu Zhou   +7 more
core   +1 more source

Research Progress of Puerarin and Its Benefits in Nonalcoholic Fatty Liver Disease: A Bibliometric Analysis

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
With the development of society and the economy, nonalcoholic fatty liver disease (NAFLD) has become a major chronic disease in contemporary society. Finding a safe, effective, and economical method is essential for the treatment of NAFLD. Puerarin is a unique component of pueraria.
Wei Wang, Xiang Liu
wiley   +1 more source

Astragaloside IV inhibits adenovirus replication and apoptosis in A549 cells in vitro

, 2011
Objectives Astragaloside IV, purified from the Chinese medical herb Astragalus membranaceus (Fisch) Bge and Astragalus caspicus Bieb, is an important natural product with multiple pharmacological actions.
Lihua Sun, Zhangyi Qu, Fuyang Jiang, Lei Shang, Fenghai Liu, Hong Gao, Yingchen Wang, Shu Wang   +7 more
core   +1 more source

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 5, May 2026.
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang, Zengkan Du, Ping Lu, Aimin Jiang, Yadong Guo, Yawei Liu, Zhijing Song, Bing Dai, Wangzheqi Zhang   +8 more
wiley   +1 more source

Clinical effect of astragaloside IV on breast carcinoma cells based on MDR1: A randomised trial

, 2021
Purpose: To study the clinical effect of astragaloside IV on breast carcinoma cells (BCCs), and its potential mechanisms with respect to multiple drug resistance-1 (MDR1)Methods: The cytotoxicity of astragaloside IV to BCCs was determined using CCK-8 ...
Yuan, Hongyin, Zhuo, Deqiang, Chen, Liangdong   +2 more
core   +1 more source

Evaluation of methyl jasmonate as elicitor in the production of cycloartane saponins in Astragalus aitosensis in vitro root cultures [PDF]

Pharmacia
Methyl jasmonate (MeJA) treatment is known to increase the levels of plant secondary metabolites. The significant medicinal benefits of cycloartane type saponins, including immune modulation, antiviral properties, and antitumor activity, drive high ...
Preslav Enchev, Yancho Zarev, Iliana Ionkova   +2 more
doaj   +3 more sources